BR112012016982A2 - "bactérias probióticas recombinantes para a prevenção e tratamento da doença inflamatória do intestino (ibd) e síndrome do intestino irritável (ibs)". - Google Patents

"bactérias probióticas recombinantes para a prevenção e tratamento da doença inflamatória do intestino (ibd) e síndrome do intestino irritável (ibs)".

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Publication number
BR112012016982A2
BR112012016982A2 BR112012016982A BR112012016982A BR112012016982A2 BR 112012016982 A2 BR112012016982 A2 BR 112012016982A2 BR 112012016982 A BR112012016982 A BR 112012016982A BR 112012016982 A BR112012016982 A BR 112012016982A BR 112012016982 A2 BR112012016982 A2 BR 112012016982A2
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BR
Brazil
Prior art keywords
protein
ibs
active fraction
ibd
treatment
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BR112012016982A
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English (en)
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BR112012016982B8 (pt
BR112012016982B1 (pt
Inventor
Jean-Michel Sallenave
Luis Bermudez-Humaran
Nathalie Vergnolle
Philippe Langella
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Inst Nat Sante Rech Med
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Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of BR112012016982A2 publication Critical patent/BR112012016982A2/pt
Publication of BR112012016982B1 publication Critical patent/BR112012016982B1/pt
Publication of BR112012016982B8 publication Critical patent/BR112012016982B8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)

Abstract

"bactérias probióticas recombinantes para a prevenção e tratamento da doença inflamatória do intestino (ibd) e síndrome do intestino irritável (ibs)". a presente invenção refere-se ao campo geral da terapia de doenças inflamatórias intestinais (ibd) e/ou síndrome do intestino irritável (ibs). assim, a invenção refere-se a uma molécula selecionada a partir da proteína trappin-2 ou uma fração ativa da proteína trappin-2, um elemento das proteínas da família wap, ou uma fração ativa do elemento das proteínas da família wap, ou um elemento das proteínas da família serpina, ou uma fração ativa de um elemento das proteínas da família serpina para o tratamento da síndrome do intestino irretável (ibs). a invenção também se refere a uma bactéria recombinante de grau alimentício que inclui um gene selecionado a partir de um gene que codifica para a proteína trappin-2, ou uma fração ativa da proteína trappin-2, um gene que codifica para um elemento das proteínas da família wap, ou uma fração ativa de um elemento das proteínas da família wap, ou um gene que codifica para um elemento das proteínas da família serpina, ou uma fração ativa de um elemento das proteínas da família serpina.
BR112012016982A 2010-01-14 2011-01-14 bactéria de ácido lático recombinante de grau alimentício e composição terapêutica BR112012016982B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR10305045.6 2010-01-14
EP10305045 2010-01-14
PCT/EP2011/050489 WO2011086172A1 (en) 2010-01-14 2011-01-14 Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (ibd) and irritable bowel syndrome (ibs)

Publications (3)

Publication Number Publication Date
BR112012016982A2 true BR112012016982A2 (pt) 2016-12-13
BR112012016982B1 BR112012016982B1 (pt) 2021-02-09
BR112012016982B8 BR112012016982B8 (pt) 2022-12-20

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ID=42224980

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012016982A BR112012016982B8 (pt) 2010-01-14 2011-01-14 bactéria de ácido lático recombinante de grau alimentício e composição terapêutica

Country Status (10)

Country Link
US (3) US20120195859A1 (pt)
EP (1) EP2451467B1 (pt)
JP (1) JP6007106B2 (pt)
KR (1) KR101667982B1 (pt)
CN (1) CN102740867A (pt)
AU (1) AU2011206532B8 (pt)
BR (1) BR112012016982B8 (pt)
CA (1) CA2786847C (pt)
ES (1) ES2613755T3 (pt)
WO (1) WO2011086172A1 (pt)

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US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
FR2990699B1 (fr) 2012-05-21 2016-02-05 Agronomique Inst Nat Rech Cassettes d'expression procaryotes regulees par le stress
WO2013188529A1 (en) * 2012-06-15 2013-12-19 Temple University Of The Commonwealth System Of Higher Education Use of isolated bacterial amyloids for treatment of inflammatory disorders or diseases of the epithelium
EP2706067A1 (en) * 2012-09-06 2014-03-12 Humboldt-Universität zu Berlin Probiotic bacteria as carrier for a helminth-derived immunomodulator for the treatment of inflammatory disorders
US20150283144A1 (en) 2012-11-01 2015-10-08 Rijksuniversiteit Groningen Methods and compositions for stimulating beneficial bacteria in the gastrointestinal tract
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
EP2851086A1 (en) 2013-09-20 2015-03-25 Sanofi Serpins: methods of therapeutic ß-cell regeneration and function
US20160002316A1 (en) 2013-02-22 2016-01-07 Joslin Diabetes Center Serpins: methods of therapeutic beta-cell regeneration and function
EP2769732A1 (en) 2013-02-22 2014-08-27 Sanofi Serpins: methods of therapeutic beta-cell regeneration and function
EP2988761A1 (en) 2013-03-05 2016-03-02 Rijksuniversiteit Groningen Use of faecali bacterium prausnitzii htf-f (dsm 26943) to suppress inflammation.
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
WO2015168534A1 (en) * 2014-05-02 2015-11-05 Novogy, Inc. Therapeutic treatment of gastrointestinal microbial imbalances through competitive microbe displacement
KR101787543B1 (ko) 2014-08-22 2017-10-19 샘표식품 주식회사 발효배양 산삼을 포함하는 항염증 조성물
WO2016124239A1 (en) 2015-02-04 2016-08-11 Aurealis Oy Recombinant probiotic bacteria for use in the treatment of a skin dysfunction
CN105106246A (zh) * 2015-08-20 2015-12-02 江南大学 一种植物乳杆菌zs2058及其用途
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Also Published As

Publication number Publication date
AU2011206532B2 (en) 2015-07-30
CA2786847A1 (en) 2011-07-21
AU2011206532A8 (en) 2015-08-06
BR112012016982B8 (pt) 2022-12-20
BR112012016982B1 (pt) 2021-02-09
US20150073125A1 (en) 2015-03-12
ES2613755T3 (es) 2017-05-25
WO2011086172A1 (en) 2011-07-21
CA2786847C (en) 2017-08-01
AU2011206532A1 (en) 2012-07-19
EP2451467A1 (en) 2012-05-16
KR20120116435A (ko) 2012-10-22
KR101667982B1 (ko) 2016-10-20
AU2011206532B8 (en) 2015-08-06
US20130344033A1 (en) 2013-12-26
JP2013517256A (ja) 2013-05-16
JP6007106B2 (ja) 2016-10-12
EP2451467B1 (en) 2016-12-21
US20120195859A1 (en) 2012-08-02
CN102740867A (zh) 2012-10-17
US9688742B2 (en) 2017-06-27

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