BR112012010148A2 - emulsão submicrometrica de paclitaxel com o uso de complexo de esteoride como carreador intermediario - Google Patents

emulsão submicrometrica de paclitaxel com o uso de complexo de esteoride como carreador intermediario

Info

Publication number
BR112012010148A2
BR112012010148A2 BR112012010148-0A BR112012010148A BR112012010148A2 BR 112012010148 A2 BR112012010148 A2 BR 112012010148A2 BR 112012010148 A BR112012010148 A BR 112012010148A BR 112012010148 A2 BR112012010148 A2 BR 112012010148A2
Authority
BR
Brazil
Prior art keywords
paclitaxel
complex
storide
submicron emulsion
intermediate carrier
Prior art date
Application number
BR112012010148-0A
Other languages
English (en)
Inventor
Liu Yuling
Zhou Cuiping
Jin Dujia
Zhang Pengxiao
Wang Renyun
Han Rui
Guo Ruifang
Fu Zhaodi
Original Assignee
Institute Of Mataria Medica, Chinese Academy Of Medical Sciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Mataria Medica, Chinese Academy Of Medical Sciences filed Critical Institute Of Mataria Medica, Chinese Academy Of Medical Sciences
Publication of BR112012010148A2 publication Critical patent/BR112012010148A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112012010148-0A 2009-10-29 2010-10-28 emulsão submicrometrica de paclitaxel com o uso de complexo de esteoride como carreador intermediario BR112012010148A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN20091023959.4 2009-10-29
CN200910236959.4A CN102048688B (zh) 2009-10-29 2009-10-29 以胆固醇复合物为中间载体的紫杉醇亚微乳
PCT/CN2010/078209 WO2011050739A1 (zh) 2009-10-29 2010-10-28 以类固醇复合物为中间载体的紫杉醇亚微乳

Publications (1)

Publication Number Publication Date
BR112012010148A2 true BR112012010148A2 (pt) 2018-03-20

Family

ID=43921351

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012010148-0A BR112012010148A2 (pt) 2009-10-29 2010-10-28 emulsão submicrometrica de paclitaxel com o uso de complexo de esteoride como carreador intermediario

Country Status (10)

Country Link
US (1) US20120308616A1 (pt)
EP (1) EP2494957A4 (pt)
JP (2) JP2013509361A (pt)
KR (3) KR20120091257A (pt)
CN (3) CN102048688B (pt)
AU (2) AU2010312021B2 (pt)
BR (1) BR112012010148A2 (pt)
CA (1) CA2779166C (pt)
HK (1) HK1175707A1 (pt)
WO (1) WO2011050739A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102048688B (zh) * 2009-10-29 2014-03-05 中国医学科学院药物研究所 以胆固醇复合物为中间载体的紫杉醇亚微乳
KR101404948B1 (ko) * 2012-08-23 2014-06-10 부경대학교 산학협력단 나비쿨라 인서타로부터 분리된 스티그마스테롤 및 5 베타-히드록시시토스타놀을 함유하는 간암의 예방 또는 치료용 조성물
EP3043781A1 (en) * 2013-09-13 2016-07-20 Arbor Therapeutics, LLC Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation
ITMI20131927A1 (it) 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
ITMI20131924A1 (it) * 2013-11-20 2015-05-21 Cosmo Technologies Ltd Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica
AU2016204933B2 (en) * 2015-07-14 2020-02-27 Best Pet Rx Ip, Inc. Poloxamer-based intralesional injections for the delivery of chemotherapeutic agents
CN107668720A (zh) * 2017-09-28 2018-02-09 山西琪尔康翅果生物制品有限公司 一种具有缓解体力疲劳的翅果油亚微乳及其制备方法
CN109908366B (zh) * 2019-03-20 2022-03-25 佛山科学技术学院 改性壳聚糖载体与药物的包合物及其制备方法
CN115252551A (zh) * 2022-08-18 2022-11-01 南昌大学 一种紫杉醇注射用微乳、冻干粉及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616330A (en) * 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
CN1676125A (zh) * 2004-03-31 2005-10-05 张昊 含有紫杉碱类或难溶药物的纳米级乳剂
WO2005118612A1 (en) * 2004-06-04 2005-12-15 Sonus Pharmaceuticals, Inc. Cholesterol/bile acid/bile acid derivative-modified therapeutic anti-cancer drugs
CN1743337B (zh) * 2004-09-03 2012-06-13 上海复旦张江生物医药股份有限公司 一种紫杉醇衍生物及其药物组合物
US8557861B2 (en) * 2004-09-28 2013-10-15 Mast Therapeutics, Inc. Low oil emulsion compositions for delivering taxoids and other insoluble drugs
CN101011355B (zh) * 2006-02-01 2013-01-02 陈献 经维生素e琥珀酸酯稳定的医药组合物、其制备及用途
TWI376239B (en) * 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
CN100998559A (zh) * 2006-12-27 2007-07-18 沈阳药科大学 多烯紫杉醇亚微乳注射剂及其制备方法
CN101396346B (zh) * 2007-09-26 2014-01-01 中国医学科学院药物研究所 紫杉醇脂质复合物
CN101878024B (zh) * 2007-11-28 2014-04-09 塞拉特药物股份有限公司 改良的紫杉烷递送系统
CN102048725B (zh) * 2009-10-29 2014-07-16 中国医学科学院药物研究所 紫杉醇胆固醇复合物
CN102048688B (zh) * 2009-10-29 2014-03-05 中国医学科学院药物研究所 以胆固醇复合物为中间载体的紫杉醇亚微乳

Also Published As

Publication number Publication date
HK1175707A1 (en) 2013-07-12
US20120308616A1 (en) 2012-12-06
CA2779166C (en) 2015-05-05
CN102048688A (zh) 2011-05-11
EP2494957A1 (en) 2012-09-05
CN104224711A (zh) 2014-12-24
WO2011050739A1 (zh) 2011-05-05
CN102686217A (zh) 2012-09-19
CN102686217B (zh) 2015-02-18
AU2016210620A1 (en) 2016-08-18
KR20120091257A (ko) 2012-08-17
CN102048688B (zh) 2014-03-05
CN104224711B (zh) 2017-04-26
AU2010312021B2 (en) 2016-08-18
KR20140041952A (ko) 2014-04-04
KR20160137646A (ko) 2016-11-30
JP2014133764A (ja) 2014-07-24
EP2494957A4 (en) 2014-04-16
AU2010312021A1 (en) 2012-06-21
JP2013509361A (ja) 2013-03-14
CA2779166A1 (en) 2011-05-05

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2465 DE 03-04-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.