BR102012006063B1 - Inibidor de met para uso em aumentar a eficiência de radioterapia e sequência de nucleotídeo - Google Patents

Inibidor de met para uso em aumentar a eficiência de radioterapia e sequência de nucleotídeo Download PDF

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Publication number
BR102012006063B1
BR102012006063B1 BR102012006063-9A BR102012006063A BR102012006063B1 BR 102012006063 B1 BR102012006063 B1 BR 102012006063B1 BR 102012006063 A BR102012006063 A BR 102012006063A BR 102012006063 B1 BR102012006063 B1 BR 102012006063B1
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BR
Brazil
Prior art keywords
met
nucleotide sequence
met inhibitor
sequence encoding
inhibitor
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BR102012006063-9A
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English (en)
Portuguese (pt)
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BR102012006063A8 (pt
BR102012006063A2 (pt
Inventor
Carla Boccaccio
Fiorella Petronzelli
Rita De Santis
Paolo Maria Comoglio
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Vertical Bio Ag
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Publication of BR102012006063A2 publication Critical patent/BR102012006063A2/pt
Publication of BR102012006063A8 publication Critical patent/BR102012006063A8/pt
Publication of BR102012006063B1 publication Critical patent/BR102012006063B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BR102012006063-9A 2011-03-18 2012-03-16 Inibidor de met para uso em aumentar a eficiência de radioterapia e sequência de nucleotídeo BR102012006063B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11158861.2A EP2500036B1 (en) 2011-03-18 2011-03-18 MET inhibitors for enhancing radiotherapy efficacy
EP11158861.2 2011-03-18

Publications (3)

Publication Number Publication Date
BR102012006063A2 BR102012006063A2 (pt) 2021-11-16
BR102012006063A8 BR102012006063A8 (pt) 2022-11-08
BR102012006063B1 true BR102012006063B1 (pt) 2023-03-07

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ID=44260211

Family Applications (1)

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BR102012006063-9A BR102012006063B1 (pt) 2011-03-18 2012-03-16 Inibidor de met para uso em aumentar a eficiência de radioterapia e sequência de nucleotídeo

Country Status (22)

Country Link
US (1) US20120237524A1 (enExample)
EP (1) EP2500036B1 (enExample)
JP (1) JP5671487B2 (enExample)
KR (1) KR101540838B1 (enExample)
CN (1) CN102688491A (enExample)
AU (1) AU2012201303B2 (enExample)
BR (1) BR102012006063B1 (enExample)
CA (1) CA2769991C (enExample)
CY (1) CY1115374T1 (enExample)
DK (1) DK2500036T3 (enExample)
EA (1) EA028590B1 (enExample)
ES (1) ES2489475T3 (enExample)
HR (1) HRP20140729T1 (enExample)
IL (1) IL218293A (enExample)
MX (1) MX2012003084A (enExample)
PL (1) PL2500036T3 (enExample)
PT (1) PT2500036E (enExample)
RS (1) RS53468B (enExample)
SG (1) SG184637A1 (enExample)
SI (1) SI2500036T1 (enExample)
SM (1) SMT201400106B (enExample)
ZA (1) ZA201201992B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210395372A1 (en) * 2018-10-09 2021-12-23 Metis Precision Medicine Sb S.R.L. Anti-met fab-fc for the treatment of a tumor and/or metastasis

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
CN110320365B (zh) * 2019-07-06 2022-07-22 湖南莱拓福生物科技有限公司 NF-κB RelA/p65蛋白位点特异性磷酸化诊断试剂盒
CN114340684B (zh) 2019-09-16 2025-09-12 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
AU2024241633A1 (en) 2023-03-30 2025-11-06 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ras抑制劑
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
CA2516236A1 (en) * 2003-02-13 2004-08-26 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
TW201319088A (zh) * 2003-07-18 2013-05-16 Amgen Inc 對肝細胞生長因子具專一性之結合劑
HN2004000285A (es) * 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
US8388958B2 (en) * 2006-02-06 2013-03-05 Metheresis Translational Research Sa Anti-MET monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products
EP2019116A1 (en) * 2007-07-26 2009-01-28 Helmholtz-Zentrum für Infektionsforschung GmbH Inhibitor of the met-receptor and its use

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210395372A1 (en) * 2018-10-09 2021-12-23 Metis Precision Medicine Sb S.R.L. Anti-met fab-fc for the treatment of a tumor and/or metastasis
US12209129B2 (en) * 2018-10-09 2025-01-28 Pierre Fabre Medicament Anti-Met fab-Fc for the treatment of a tumor and/or metastasis

Also Published As

Publication number Publication date
SI2500036T1 (sl) 2014-09-30
DK2500036T3 (da) 2014-08-04
CN102688491A (zh) 2012-09-26
KR101540838B1 (ko) 2015-08-06
KR20120106582A (ko) 2012-09-26
SG184637A1 (en) 2012-10-30
BR102012006063A8 (pt) 2022-11-08
ES2489475T3 (es) 2014-09-02
EA201200329A2 (ru) 2012-09-28
EA201200329A3 (ru) 2013-01-30
IL218293A0 (en) 2012-07-31
AU2012201303B2 (en) 2013-11-07
HK1174539A1 (en) 2013-06-14
PL2500036T3 (pl) 2014-10-31
CA2769991C (en) 2018-05-15
CA2769991A1 (en) 2012-09-18
JP5671487B2 (ja) 2015-02-18
JP2012196206A (ja) 2012-10-18
SMT201400106B (it) 2014-11-10
CY1115374T1 (el) 2017-01-04
BR102012006063A2 (pt) 2021-11-16
MX2012003084A (es) 2012-09-17
AU2012201303A1 (en) 2012-10-04
ZA201201992B (en) 2015-05-27
RS53468B (sr) 2014-12-31
EA028590B1 (ru) 2017-12-29
EP2500036B1 (en) 2014-05-07
US20120237524A1 (en) 2012-09-20
PT2500036E (pt) 2014-08-25
IL218293A (en) 2016-06-30
HRP20140729T1 (hr) 2014-08-29
EP2500036A1 (en) 2012-09-19

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Date Code Title Description
B03A Publication of a patent application or of a certificate of addition of invention [chapter 3.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25A Requested transfer of rights approved

Owner name: METIS PRECISION MEDICINE SB S.R.L. (IT)

B25A Requested transfer of rights approved

Owner name: VERTICAL BIO AG (CH)

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/03/2012, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.