BR0317119A - Agente antitumor, inibidor de proliferação celular, e, análogo de 3-fenil-cinolina - Google Patents

Agente antitumor, inibidor de proliferação celular, e, análogo de 3-fenil-cinolina

Info

Publication number
BR0317119A
BR0317119A BR0317119-1A BR0317119A BR0317119A BR 0317119 A BR0317119 A BR 0317119A BR 0317119 A BR0317119 A BR 0317119A BR 0317119 A BR0317119 A BR 0317119A
Authority
BR
Brazil
Prior art keywords
cinoline
phenyl
cell proliferation
analog
antitumor agent
Prior art date
Application number
BR0317119-1A
Other languages
English (en)
Inventor
Shunsuke Kuroiwa
Junko Odanaka
Sakiko Maruyama
Yoshitaka Sato
Arihiro Tomura
Hiroshi Sato
Yoshikazu Suzuki
Original Assignee
Nippon Kayaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Kk filed Critical Nippon Kayaku Kk
Publication of BR0317119A publication Critical patent/BR0317119A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/28—Cinnolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"AGENTE ANTITUMORI INIBIDOR DE PROLIFERAçãO CELULAR, E, ANáLOGO DE 3-FENIL-CINOLINA" Um homólogo de 3-fenil-cinolina ou um sal famaceuticamente aceitável do mesmo; e um agente citostático ou um agente antitumor contendo o mesmo.
BR0317119-1A 2002-12-10 2003-12-10 Agente antitumor, inibidor de proliferação celular, e, análogo de 3-fenil-cinolina BR0317119A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002357556 2002-12-10
JP2003166082 2003-06-11
JP2003183766 2003-06-27
PCT/JP2003/015767 WO2004052866A1 (ja) 2002-12-10 2003-12-10 ３−フェニル−シンノリン類縁体とそれを用いた抗腫瘍剤

Publications (1)

Publication Number Publication Date
BR0317119A true BR0317119A (pt) 2005-10-25

Family

ID=32512120

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317119-1A BR0317119A (pt) 2002-12-10 2003-12-10 Agente antitumor, inibidor de proliferação celular, e, análogo de 3-fenil-cinolina

Country Status (9)

Country Link
US (1) US7563893B2 (pt)
EP (1) EP1571148A4 (pt)
JP (1) JPWO2004052866A1 (pt)
KR (1) KR20050085474A (pt)
AU (1) AU2003289002B2 (pt)
BR (1) BR0317119A (pt)
CA (1) CA2508010A1 (pt)
TW (1) TWI314455B (pt)
WO (1) WO2004052866A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2568301A1 (en) * 2004-06-09 2005-12-22 Nippon Kayaku Kabushiki Kaisha 3-phenyltetrahydrocinnolin-5-ol derivatives and medicinal use thereof of
JP2006225333A (ja) * 2005-02-18 2006-08-31 Nippon Kayaku Co Ltd 新規ピラノピリダジン誘導体とその用途
UA94052C2 (uk) * 2005-07-05 2011-04-11 Ф. Хоффманн-Ля Рош Аг Похідні піридазину
TW200817424A (en) 2006-08-04 2008-04-16 Daiichi Sankyo Co Ltd Benzylphenyl glucopyranoside derivatives
JP2010070452A (ja) * 2007-01-23 2010-04-02 Nippon Kayaku Co Ltd 新規トリフルオロメチルフェニルテトラヒドロシンノリン誘導体とその用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0628550T3 (da) 1993-06-08 1998-09-28 Vertex Pharma Pyridazin som interleukin-1 beta-omdannede enzyminhibitorer
US6008208A (en) * 1995-10-23 1999-12-28 Osteoscreen, Inc. Compositions and methods for treating bone deficit conditions
US5919808A (en) * 1996-10-23 1999-07-06 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions

Also Published As

Publication number Publication date
TW200412965A (en) 2004-08-01
EP1571148A1 (en) 2005-09-07
AU2003289002A1 (en) 2004-06-30
CA2508010A1 (en) 2004-06-24
TWI314455B (en) 2009-09-11
US20060058305A1 (en) 2006-03-16
US7563893B2 (en) 2009-07-21
JPWO2004052866A1 (ja) 2006-04-13
KR20050085474A (ko) 2005-08-29
AU2003289002B2 (en) 2009-11-05
EP1571148A4 (en) 2007-08-22
WO2004052866A1 (ja) 2004-06-24

Similar Documents

Publication Publication Date Title
CL2004001174A1 (es) Composicion farmaceutica que comprende: 1-(4-fluorofenil)-3(r)-[3-(4-fluorofenil)-3(s)-hidroxipropil]-4(s)-(4-hidroxifenil)-2-acetidinona (ezetimiba) y excipientes; y su uso en el tratamiento y/o prevencion de aterosclerosis, hipercolesterolemia, dia
SE0102315D0 (sv) Compounds
CO5611160A2 (es) Conjugados de agentes terapeuticos o citotoxicos y peptidos biologicamente activos
TR200101859T2 (tr) Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
RS50091B (sr) Upotreba retigabina u lečenju neuropatskog bola
BR0116452A (pt) Composto, composição farmacêutica, uso de um composto
BR0012046A (pt) Composto heterocìclico, composição farmacêutica, inibidor de ativação de ap-1 ou um inibidor da ativação de nf-kappab, inibidor da produção de citocina inflamatória, e, inibidor da produção de metaloprotease de matriz ou inibidor da expressão do fator de adesão de célula inflamatória
HUP0301320A2 (hu) Glikopeptid-foszfonát-származékok
DE69907977D1 (de) Pyrrolobenzodiazepine
ATE428372T1 (de) Beschichtung von stents zur verhinderung von restenose
CY1108610T1 (el) Πεπτιδια της il-2 και παραγωγα αυτων και χρηση αυτων ως θεραπευτικοι παραγοντες
ATE231872T1 (de) Thiazolopyrimidinderivate
AU4064597A (en) Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
ATE218581T1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
YU60900A (sh) Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja
SE0101932D0 (sv) Pharmaceutical combinations
ME00578A (en) Use of gastrointestinal lipase inhibitors
ATE303384T1 (de) 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren
HUP0300848A2 (hu) Kamptotecint és egy pirimidinszármazékot tartalmazó készítmény rák kezelésére
SE0004710L (sv) System och förfarande
TR200001102T2 (tr) İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
BR0317119A (pt) Agente antitumor, inibidor de proliferação celular, e, análogo de 3-fenil-cinolina
IT1289154B1 (it) Derivati di isoflavone loro preparazione e loro impiego terapeutico
PT1052991E (pt) Utilizacao de loperamida para o tratamento de infeccoes microbianas

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08L Patent application lapsed because of non payment of annual fee [chapter 8.12 patent gazette]

Free format text: REFERENTE AO NAO RECOLHIMENTO DAS 9A E 10A ANUIDADES.

B08I Publication cancelled [chapter 8.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 8.12 NA RPI NO 2257 DE 08/04/2014 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 9A, 10A, 11A, 12A, 13A, 14A, 15A E 16A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2602 DE 17-11-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.