BR0315888A - Métodos para a preparação de oxazolidinonas n-ariladas via uma reação de acoplamento cruzada catalisada por cobre - Google Patents
Métodos para a preparação de oxazolidinonas n-ariladas via uma reação de acoplamento cruzada catalisada por cobreInfo
- Publication number
- BR0315888A BR0315888A BR0315888-8A BR0315888A BR0315888A BR 0315888 A BR0315888 A BR 0315888A BR 0315888 A BR0315888 A BR 0315888A BR 0315888 A BR0315888 A BR 0315888A
- Authority
- BR
- Brazil
- Prior art keywords
- arylated
- preparing
- methods
- coupling reaction
- oxazolidinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D291/00—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
- C07D291/02—Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
- C07D291/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"MéTODOS PARA A PREPARAçãO DE OXAZOLIDINONAS N-ARILADAS VIA UMA REAçãO DE ACOPLAMENTO CRUZADO CATALISADA POR COBRE". A presente invenção refere-se a métodos para a preparação de compostos de oxazolidinona N-arilados via uma reação de acoplamento cruzado catalisada por cobre.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42332802P | 2002-11-01 | 2002-11-01 | |
US10/645,779 US7223870B2 (en) | 2002-11-01 | 2003-08-21 | Methods for preparing N-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
PCT/IB2003/004708 WO2004039788A1 (en) | 2002-11-01 | 2003-10-22 | Methods for preparing n-arylated oxazolidinones via a copper catalyzed cross coupling reaction |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315888A true BR0315888A (pt) | 2005-10-04 |
Family
ID=32233544
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315888-8A BR0315888A (pt) | 2002-11-01 | 2003-10-22 | Métodos para a preparação de oxazolidinonas n-ariladas via uma reação de acoplamento cruzada catalisada por cobre |
Country Status (10)
Country | Link |
---|---|
US (2) | US7223870B2 (pt) |
EP (1) | EP1562916A1 (pt) |
JP (1) | JP2006514983A (pt) |
AR (1) | AR041878A1 (pt) |
AU (1) | AU2003269414A1 (pt) |
BR (1) | BR0315888A (pt) |
CA (1) | CA2501314A1 (pt) |
MX (1) | MXPA05004661A (pt) |
TW (1) | TW200420547A (pt) |
WO (1) | WO2004039788A1 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003269399A1 (en) * | 2002-11-01 | 2004-05-25 | Pfizer Products Inc. | Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination |
TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
KR101999300B1 (ko) | 2007-03-12 | 2019-07-12 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
EP2033957A1 (en) * | 2007-09-06 | 2009-03-11 | SOLVAY (Société Anonyme) | Process for the manufacture of alkyl compounds |
KR101674146B1 (ko) | 2008-10-10 | 2016-11-08 | 머크 샤프 앤드 돔 코포레이션 | 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법 |
MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
WO2013155506A1 (en) | 2012-04-14 | 2013-10-17 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
MX355945B (es) | 2013-03-14 | 2018-05-07 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
ES2846823T3 (es) | 2013-03-15 | 2021-07-29 | Intra Cellular Therapies Inc | Compuestos orgánicos |
AU2014360452C1 (en) | 2013-12-03 | 2019-05-16 | Intra-Cellular Therapies, Inc. | Novel methods |
BR112016023162B1 (pt) | 2014-04-04 | 2022-11-29 | Intra-Cellular Therapies, Inc | Compostos orgânicos gama-carbolinas, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento ou na profilaxia de transtornos de sistema nervoso central |
CN106456638A (zh) | 2014-04-04 | 2017-02-22 | 细胞内治疗公司 | 有机化合物 |
PE20170682A1 (es) | 2014-08-04 | 2017-06-15 | Nuevolution As | Derivados de pirimidina sustituidos con heterociclilo opcionalmente condensados utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias |
CN104327007B (zh) * | 2014-10-20 | 2016-07-27 | 安徽师范大学 | 3,4,5-三取代噁唑烷酮类化合物及其制备方法 |
CN105153059B (zh) * | 2015-09-11 | 2018-03-06 | 苏州大学 | 一种噁唑烷酮化合物的制备方法 |
PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
EP3888656A1 (en) | 2016-03-25 | 2021-10-06 | Intra-Cellular Therapies, Inc. | Deuterated heterocyclic gamma-carboline compounds and their use in the treatment or prophylaxis of a central nervous system disorder |
JP2019510039A (ja) | 2016-03-28 | 2019-04-11 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規組成物および方法 |
JP6997718B2 (ja) | 2016-03-28 | 2022-01-18 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規共結晶 |
JP2019513143A (ja) | 2016-03-28 | 2019-05-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規塩類および結晶 |
CN110072518B (zh) | 2016-10-12 | 2021-10-26 | 细胞内治疗公司 | 无定形固体分散体 |
JP6987868B2 (ja) | 2016-12-29 | 2022-01-05 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2019011329A (es) | 2017-03-24 | 2019-12-02 | Intra Celular Therapies Inc | Composiciones novedosas y metodos. |
AU2018307479B2 (en) | 2017-07-26 | 2024-06-20 | Intra-Cellular Therapies, Inc. | Organic compounds |
IL272252B2 (en) | 2017-07-26 | 2024-03-01 | Intra Cellular Therapies Inc | Transformed histories of gamma-carbolines fused with heterocyclics, pharmaceutical preparations containing them and their use for treatment |
CA3102948A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
KR20210031455A (ko) | 2018-06-11 | 2021-03-19 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로환 융합 감마-카르볼린 합성 |
MX2021002321A (es) | 2018-08-31 | 2021-04-28 | Intra Cellular Therapies Inc | Nuevos metodos. |
AU2019328528A1 (en) | 2018-08-31 | 2021-03-18 | Intra-Cellular Therapies, Inc. | Novel methods |
KR20220029744A (ko) | 2019-07-07 | 2022-03-08 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규 방법 |
US11447479B2 (en) | 2019-12-20 | 2022-09-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
WO2021198955A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
JP2023519605A (ja) | 2020-03-31 | 2023-05-11 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
US11990584B2 (en) * | 2020-11-10 | 2024-05-21 | Lg Energy Solution, Ltd. | Non-aqueous electrolyte solution for lithium secondary battery and lithium secondary battery including the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
HN2000000203A (es) | 1999-11-30 | 2001-06-13 | Pfizer Prod Inc | Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas. |
US6759554B2 (en) | 2001-04-24 | 2004-07-06 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
-
2003
- 2003-08-21 US US10/645,779 patent/US7223870B2/en not_active Expired - Fee Related
- 2003-10-22 CA CA002501314A patent/CA2501314A1/en not_active Abandoned
- 2003-10-22 MX MXPA05004661A patent/MXPA05004661A/es unknown
- 2003-10-22 EP EP03751196A patent/EP1562916A1/en not_active Withdrawn
- 2003-10-22 JP JP2005501838A patent/JP2006514983A/ja not_active Withdrawn
- 2003-10-22 WO PCT/IB2003/004708 patent/WO2004039788A1/en active Application Filing
- 2003-10-22 BR BR0315888-8A patent/BR0315888A/pt not_active IP Right Cessation
- 2003-10-22 AU AU2003269414A patent/AU2003269414A1/en not_active Abandoned
- 2003-10-30 AR ARP030103977A patent/AR041878A1/es unknown
- 2003-10-31 TW TW092130501A patent/TW200420547A/zh unknown
-
2006
- 2006-07-31 US US11/461,203 patent/US20070049759A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2006514983A (ja) | 2006-05-18 |
WO2004039788A1 (en) | 2004-05-13 |
US20070049759A1 (en) | 2007-03-01 |
AR041878A1 (es) | 2005-06-01 |
US20040122226A1 (en) | 2004-06-24 |
MXPA05004661A (es) | 2005-06-08 |
TW200420547A (en) | 2004-10-16 |
US7223870B2 (en) | 2007-05-29 |
AU2003269414A1 (en) | 2004-05-25 |
EP1562916A1 (en) | 2005-08-17 |
CA2501314A1 (en) | 2004-05-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |