BR0313386A - Processo aperfeiçoado para hidroxiazapironas - Google Patents

Processo aperfeiçoado para hidroxiazapironas

Info

Publication number
BR0313386A
BR0313386A BR0313386-9A BR0313386A BR0313386A BR 0313386 A BR0313386 A BR 0313386A BR 0313386 A BR0313386 A BR 0313386A BR 0313386 A BR0313386 A BR 0313386A
Authority
BR
Brazil
Prior art keywords
hydroxyazapyrones
azapyrones
hydroxyazone
formula
enolate
Prior art date
Application number
BR0313386-9A
Other languages
English (en)
Inventor
Jeffrey Depue
Atul S Kotnis
Simon Leung
Eric D Dowdy
Daniel J Watson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR0313386A publication Critical patent/BR0313386A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO APERFEIçOADO PARA HIDROXIAZAPIRONAS". A presente invenção descreve um processo para preparação de hidroxiazapironas da Fórmula (I) a partir de azapironas da Fórmula (II). O processo compreende tratar azapironas com uma base forte, monitoramento da formação de enolato de azapirona através de espectroscopia IR, e reação do enolato com uma fonte de oxigênio molecular na presença de um redutor. O processo é adequado para produção em grande escala de hidroxiazapironas.
BR0313386-9A 2002-08-12 2003-08-07 Processo aperfeiçoado para hidroxiazapironas BR0313386A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40275902P 2002-08-12 2002-08-12
PCT/US2003/024934 WO2004014309A2 (en) 2002-08-12 2003-08-07 Improved process for hydroxyazapirones

Publications (1)

Publication Number Publication Date
BR0313386A true BR0313386A (pt) 2005-06-14

Family

ID=31715896

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313386-9A BR0313386A (pt) 2002-08-12 2003-08-07 Processo aperfeiçoado para hidroxiazapironas

Country Status (12)

Country Link
US (1) US6897309B2 (pt)
EP (1) EP1542689A2 (pt)
JP (1) JP2005535708A (pt)
CN (1) CN1674904A (pt)
AU (1) AU2003259086A1 (pt)
BR (1) BR0313386A (pt)
CA (1) CA2495659A1 (pt)
IL (1) IL166514A0 (pt)
MX (1) MXPA05001545A (pt)
PL (1) PL374000A1 (pt)
TW (1) TW200409767A (pt)
WO (1) WO2004014309A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200521125A (en) * 2003-11-18 2005-07-01 Bristol Myers Squibb Co Continuous process for producing hydroxyazapirones by oxidation
CN106748693B (zh) * 2016-11-16 2019-09-20 浙江新和成股份有限公司 一种α-羟基酮化合物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150365A (en) * 1999-08-05 2000-11-21 Bristol-Myers Squibb Company Anxiety method
US6534507B1 (en) 1999-12-20 2003-03-18 Fabre-Kramer Pharmaceuticals, Inc. Methods for treating psychological disorders using bioactive metabolites of gepirone
AU2001295478A1 (en) 2000-08-22 2002-03-04 Akzo Nobel N.V. Active metabolite of gepirone
US6593331B2 (en) * 2001-04-17 2003-07-15 Laboratories Upsa Method for treatment of pain
WO2003010161A1 (en) * 2001-07-24 2003-02-06 Bristol-Myers Squibb Company S-6-hydroxy-buspirone
US6686361B2 (en) * 2001-07-24 2004-02-03 Bristol-Myers Squibb Company R-6-hydroxy-buspirone

Also Published As

Publication number Publication date
IL166514A0 (en) 2006-01-15
PL374000A1 (en) 2005-09-19
JP2005535708A (ja) 2005-11-24
CN1674904A (zh) 2005-09-28
WO2004014309A3 (en) 2004-06-24
US6897309B2 (en) 2005-05-24
CA2495659A1 (en) 2004-02-19
TW200409767A (en) 2004-06-16
AU2003259086A1 (en) 2004-02-25
EP1542689A2 (en) 2005-06-22
WO2004014309A2 (en) 2004-02-19
MXPA05001545A (es) 2005-04-19
US20040067958A1 (en) 2004-04-08

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]