BR0309210A - Formas de cristal da n-(trans-4-isopropil ciclohexilcarbonil)-d-fenilalanina - Google Patents
Formas de cristal da n-(trans-4-isopropil ciclohexilcarbonil)-d-fenilalaninaInfo
- Publication number
- BR0309210A BR0309210A BR0309210-0A BR0309210A BR0309210A BR 0309210 A BR0309210 A BR 0309210A BR 0309210 A BR0309210 A BR 0309210A BR 0309210 A BR0309210 A BR 0309210A
- Authority
- BR
- Brazil
- Prior art keywords
- nateglinide
- cyclohexylcarbonyl
- trans
- crystal
- crystal forms
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 7
- OELFLUMRDSZNSF-OFLPRAFFSA-N (2R)-2-[[oxo-(4-propan-2-ylcyclohexyl)methyl]amino]-3-phenylpropanoic acid Chemical compound C1CC(C(C)C)CCC1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-OFLPRAFFSA-N 0.000 title 1
- OELFLUMRDSZNSF-BRWVUGGUSA-N nateglinide Chemical compound C1C[C@@H](C(C)C)CC[C@@H]1C(=O)N[C@@H](C(O)=O)CC1=CC=CC=C1 OELFLUMRDSZNSF-BRWVUGGUSA-N 0.000 abstract 10
- 229960000698 nateglinide Drugs 0.000 abstract 9
- 239000002904 solvent Substances 0.000 abstract 3
- 238000001556 precipitation Methods 0.000 abstract 2
- -1 CYCLOHEXYLCARBONYL Chemical class 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37262502P | 2002-04-15 | 2002-04-15 | |
| PCT/EP2003/003864 WO2003087038A1 (en) | 2002-04-15 | 2003-04-14 | Crystal forms of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0309210A true BR0309210A (pt) | 2005-02-09 |
Family
ID=29250881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0309210-0A BR0309210A (pt) | 2002-04-15 | 2003-04-14 | Formas de cristal da n-(trans-4-isopropil ciclohexilcarbonil)-d-fenilalanina |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7247746B2 (enExample) |
| EP (1) | EP1497258A1 (enExample) |
| JP (2) | JP4615866B2 (enExample) |
| CN (1) | CN1304366C (enExample) |
| AU (1) | AU2003242520A1 (enExample) |
| BR (1) | BR0309210A (enExample) |
| CA (1) | CA2482669A1 (enExample) |
| WO (1) | WO2003087038A1 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6861553B2 (en) | 2002-07-03 | 2005-03-01 | Teva Pharmaceuticals Industries Ltd. | Process for preparing nateglinide and intermediates thereof |
| US7358390B2 (en) | 2002-07-18 | 2008-04-15 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7534913B2 (en) | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
| US7148376B2 (en) | 2002-07-18 | 2006-12-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| US7420084B2 (en) * | 2002-07-18 | 2008-09-02 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of nateglinide |
| WO2004020396A1 (en) * | 2002-08-28 | 2004-03-11 | Dr. Reddy's Laboratories Limited | Crystalline form of nateglinide and process for preparation thereof |
| US7449519B2 (en) * | 2003-02-18 | 2008-11-11 | Konishi Co., Ltd. | Curing resin, method for producing same and curing resin composition |
| HU227073B1 (hu) * | 2003-07-10 | 2010-06-28 | Richter Gedeon Nyrt | Eljárás királisan tiszta N-(transz-4-izopropil-ciklohexilkarbonil)-D-fenil-alanin (nateglinid) és kristálymódosulatainak elõállítására, valamint a G-kristálymódosulata |
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| US9498461B2 (en) | 2012-05-23 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
| US9624168B2 (en) | 2012-09-06 | 2017-04-18 | Cellix Bio Private Limited | Compositions and methods for the treatment inflammation and lipid disorders |
| CA2873029A1 (en) | 2012-09-08 | 2014-03-13 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| EP3240779B1 (en) | 2014-09-26 | 2020-10-28 | Cellixbio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
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| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| CN107207411A (zh) | 2014-12-01 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| ES2905771T3 (es) | 2015-01-06 | 2022-04-12 | Cellix Bio Private Ltd | Composiciones y procedimientos para el tratamiento de la inflamación y del dolor |
| CN109100430A (zh) * | 2017-06-20 | 2018-12-28 | 珠海同益制药有限公司 | 一种那格列奈手性异构体色谱分析方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6354321A (ja) * | 1985-03-27 | 1988-03-08 | Ajinomoto Co Inc | 血糖降下剤 |
| US5463116A (en) * | 1991-07-30 | 1995-10-31 | Ajinomoto Co., Inc. | Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them |
| DE69217762T2 (de) * | 1991-07-30 | 1997-10-09 | Ajinomoto Kk | Kristalle von N-(Trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanin und Verfahren zu ihrer Herstellung |
| EP1435912A4 (en) | 2001-09-12 | 2005-03-30 | Alembic Ltd | NOVEL STABLE CRYSTAL FORM OF N- (TRANS-4-ISOPROPYLCYCLOHEXYL CARBONYL) -D-PHENYLALANINE AND PREPARATION METHOD THEREOF |
| WO2003087039A1 (en) * | 2002-04-15 | 2003-10-23 | Ajinomoto Co., Inc. | Novel nateglinide crystal |
-
2003
- 2003-04-14 US US10/510,927 patent/US7247746B2/en not_active Expired - Fee Related
- 2003-04-14 EP EP03746296A patent/EP1497258A1/en not_active Withdrawn
- 2003-04-14 WO PCT/EP2003/003864 patent/WO2003087038A1/en not_active Ceased
- 2003-04-14 AU AU2003242520A patent/AU2003242520A1/en not_active Abandoned
- 2003-04-14 CN CNB038084368A patent/CN1304366C/zh not_active Expired - Lifetime
- 2003-04-14 JP JP2003583994A patent/JP4615866B2/ja not_active Expired - Fee Related
- 2003-04-14 BR BR0309210-0A patent/BR0309210A/pt not_active IP Right Cessation
- 2003-04-14 CA CA002482669A patent/CA2482669A1/en not_active Abandoned
-
2007
- 2007-06-20 US US11/765,818 patent/US20080081927A1/en not_active Abandoned
-
2008
- 2008-07-21 US US12/220,061 patent/US20080319222A1/en not_active Abandoned
-
2010
- 2010-07-09 JP JP2010156749A patent/JP2010265295A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1497258A1 (en) | 2005-01-19 |
| AU2003242520A1 (en) | 2003-10-27 |
| CN1646481A (zh) | 2005-07-27 |
| CA2482669A1 (en) | 2003-10-23 |
| JP2005522503A (ja) | 2005-07-28 |
| CN1304366C (zh) | 2007-03-14 |
| JP4615866B2 (ja) | 2011-01-19 |
| US20080319222A1 (en) | 2008-12-25 |
| US7247746B2 (en) | 2007-07-24 |
| US20050256336A1 (en) | 2005-11-17 |
| WO2003087038A1 (en) | 2003-10-23 |
| US20080081927A1 (en) | 2008-04-03 |
| JP2010265295A (ja) | 2010-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE AS 8A E 9A ANUIDADES. |