BR0309111A - Método para a sìntese de beta-l-5-fluoro-2' ,3' -dideóxi - 2' ,3' -dideidrocitidina - Google Patents
Método para a sìntese de beta-l-5-fluoro-2' ,3' -dideóxi - 2' ,3' -dideidrocitidinaInfo
- Publication number
- BR0309111A BR0309111A BR0309111-2A BR0309111A BR0309111A BR 0309111 A BR0309111 A BR 0309111A BR 0309111 A BR0309111 A BR 0309111A BR 0309111 A BR0309111 A BR 0309111A
- Authority
- BR
- Brazil
- Prior art keywords
- dideoxy
- fluoro
- synthesis
- beta
- dehydrocytidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
"MéTODO PARA A SìNTESE DE BETA-L-5-FLUORO-2,<39>,3<39>-DIDEóXI-2<39>,3<39>-DIDEID ROCITIDINA". A invenção apresenta um método para a síntese de <225>-L-5-fluoro-2<39>,3<39>-dideóxi-2<39>,3<39>-dideidrocitidin a (<225>-L-FD4C). O método permite a produção em larga escala de <225>-L-FD4C de uma forma eficiente, eficiente em custo, e saudável do ponto de vista ambiental.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37200602P | 2002-04-12 | 2002-04-12 | |
PCT/US2003/011445 WO2003087119A1 (en) | 2002-04-12 | 2003-04-11 | METHOD FOR SYNTHESIZING β-L-FLUORO-2´,3´DIDEHYDROCYTIDINE (β-L-FD4C) |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0309111A true BR0309111A (pt) | 2005-02-01 |
Family
ID=29250776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0309111-2A BR0309111A (pt) | 2002-04-12 | 2003-04-11 | Método para a sìntese de beta-l-5-fluoro-2' ,3' -dideóxi - 2' ,3' -dideidrocitidina |
Country Status (14)
Country | Link |
---|---|
US (1) | US6897302B2 (pt) |
EP (1) | EP1495040A4 (pt) |
JP (1) | JP2005527589A (pt) |
KR (1) | KR20050005442A (pt) |
CN (1) | CN1329407C (pt) |
AU (1) | AU2003234737B2 (pt) |
BR (1) | BR0309111A (pt) |
CA (1) | CA2481572A1 (pt) |
MX (1) | MXPA04009986A (pt) |
NO (1) | NO20044927L (pt) |
PL (1) | PL371913A1 (pt) |
RU (1) | RU2310661C2 (pt) |
UA (1) | UA77291C2 (pt) |
WO (1) | WO2003087119A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2694029C (en) * | 2007-07-26 | 2016-10-04 | Lexicon Pharmaceuticals, Inc. | Methods and compounds useful for the preparation of sodium glucose co-transporter 2 inhibitors |
JP5749017B2 (ja) | 2008-01-22 | 2015-07-15 | ダウ アグロサイエンシィズ エルエルシー | 5−フルオロピリミジン誘導体 |
PL2861611T3 (pl) | 2012-05-25 | 2017-08-31 | Janssen Sciences Ireland Uc | Nukleozydy uracylowe spirooksetanu |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5204466A (en) | 1990-02-01 | 1993-04-20 | Emory University | Method and compositions for the synthesis of bch-189 and related compounds |
IL100965A (en) * | 1991-02-22 | 1999-12-31 | Univ Emory | 2 - Hydroxymethyl - 5 -) 5 - Fluorocytocin - 1 - Eyal (- 1, 3 - Oxathiolane, its resolution and pharmaceuticals containing it |
TW374087B (en) | 1993-05-25 | 1999-11-11 | Univ Yale | L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents |
US5627160A (en) | 1993-05-25 | 1997-05-06 | Yale University | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents |
US5703058A (en) | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
US5869461A (en) | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
US6005097A (en) * | 1996-06-14 | 1999-12-21 | Vion Pharmaceuticals, Inc. | Processes for high-yield diastereoselective synthesis of dideoxynucleosides |
US6280940B1 (en) | 1998-08-05 | 2001-08-28 | Agouron Pharmaceuticals, Inc. | Reporter gene system for use in cell-based assessment of inhibitors of the Hepatitis C virus protease |
CN1342156A (zh) | 1998-08-25 | 2002-03-27 | 耶鲁大学 | 用赛菊宁黄质及其类似物抑制和治疗乙型肝炎病毒和黄病毒 |
JP3889708B2 (ja) | 2000-11-20 | 2007-03-07 | ブリストル−マイヤーズ スクイブ カンパニー | C型肝炎トリペプチド阻害剤 |
CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
US6689559B2 (en) | 2001-11-29 | 2004-02-10 | The Research Foundation Of The State University Of New York | Efficient hepatitis C virus replicon and its use in identifying antiviral compounds |
-
2003
- 2003-04-11 US US10/411,929 patent/US6897302B2/en not_active Expired - Lifetime
- 2003-04-11 AU AU2003234737A patent/AU2003234737B2/en not_active Ceased
- 2003-04-11 CN CNB038113155A patent/CN1329407C/zh not_active Expired - Lifetime
- 2003-04-11 PL PL03371913A patent/PL371913A1/xx not_active Application Discontinuation
- 2003-04-11 RU RU2004133062/04A patent/RU2310661C2/ru not_active IP Right Cessation
- 2003-04-11 JP JP2003584075A patent/JP2005527589A/ja active Pending
- 2003-04-11 EP EP03728393A patent/EP1495040A4/en not_active Withdrawn
- 2003-04-11 CA CA002481572A patent/CA2481572A1/en not_active Abandoned
- 2003-04-11 BR BR0309111-2A patent/BR0309111A/pt not_active IP Right Cessation
- 2003-04-11 KR KR10-2004-7016211A patent/KR20050005442A/ko active IP Right Grant
- 2003-04-11 WO PCT/US2003/011445 patent/WO2003087119A1/en active Application Filing
- 2003-04-11 MX MXPA04009986A patent/MXPA04009986A/es active IP Right Grant
- 2003-11-04 UA UA20041109254A patent/UA77291C2/uk unknown
-
2004
- 2004-11-11 NO NO20044927A patent/NO20044927L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2481572A1 (en) | 2003-10-23 |
RU2310661C2 (ru) | 2007-11-20 |
US20040147479A1 (en) | 2004-07-29 |
KR20050005442A (ko) | 2005-01-13 |
WO2003087119A1 (en) | 2003-10-23 |
NO20044927L (no) | 2005-01-10 |
EP1495040A1 (en) | 2005-01-12 |
US6897302B2 (en) | 2005-05-24 |
RU2004133062A (ru) | 2005-06-10 |
JP2005527589A (ja) | 2005-09-15 |
UA77291C2 (en) | 2006-11-15 |
AU2003234737B2 (en) | 2009-08-27 |
CN1329407C (zh) | 2007-08-01 |
MXPA04009986A (es) | 2005-08-16 |
AU2003234737A1 (en) | 2003-10-27 |
EP1495040A4 (en) | 2006-01-25 |
CN1653078A (zh) | 2005-08-10 |
PL371913A1 (en) | 2005-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012. |