BR0308612A - Taxanos rotulados - Google Patents
Taxanos rotuladosInfo
- Publication number
- BR0308612A BR0308612A BR0308612-7A BR0308612A BR0308612A BR 0308612 A BR0308612 A BR 0308612A BR 0308612 A BR0308612 A BR 0308612A BR 0308612 A BR0308612 A BR 0308612A
- Authority
- BR
- Brazil
- Prior art keywords
- taxanes
- labeled
- relates
- present
- benzoyl
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052805 deuterium Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical group C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"TAXANOS ROTULADOS". A presente invenção refere-se a taxanos estáveis rotulados, caracterizados pelo fato dos isótopos estarem presentes no grupo benzoilóxi na posição C-2. Mais particularmente, um ou mais dos átomos de hidrogênio ou de carbono do resíduo benzoíla na posição C-2 da cadeia principal do taxano é substituído respectivamente, de deutério ou C13. Também refere-se a um processo para sua preparação e seu uso como padrão interno em métodos analíticos para determinar taxanos, úteis como drogas anticâncer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02076113 | 2002-03-21 | ||
| PCT/EP2003/002634 WO2003080587A1 (en) | 2002-03-21 | 2003-03-12 | Labelled taxanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0308612A true BR0308612A (pt) | 2005-02-09 |
Family
ID=28051803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0308612-7A BR0308612A (pt) | 2002-03-21 | 2003-03-12 | Taxanos rotulados |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1490348A1 (pt) |
| JP (1) | JP2005530715A (pt) |
| AU (1) | AU2003227063A1 (pt) |
| BR (1) | BR0308612A (pt) |
| CA (1) | CA2479273A1 (pt) |
| MX (1) | MXPA04009083A (pt) |
| WO (1) | WO2003080587A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007065869A1 (en) * | 2005-12-06 | 2007-06-14 | Nerviano Medical Sciences S.R.L. | Labelled docetaxel |
| WO2015064530A1 (ja) * | 2013-10-28 | 2015-05-07 | 株式会社島津製作所 | クロマトグラフを用いたマルチ定量分析方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358996B1 (en) * | 2000-06-09 | 2002-03-19 | Napro Biotherapeutics, Inc. | Stable isotope labeling of paclitaxel |
-
2003
- 2003-03-12 JP JP2003578342A patent/JP2005530715A/ja active Pending
- 2003-03-12 AU AU2003227063A patent/AU2003227063A1/en not_active Abandoned
- 2003-03-12 WO PCT/EP2003/002634 patent/WO2003080587A1/en not_active Application Discontinuation
- 2003-03-12 BR BR0308612-7A patent/BR0308612A/pt not_active Application Discontinuation
- 2003-03-12 MX MXPA04009083A patent/MXPA04009083A/es unknown
- 2003-03-12 CA CA002479273A patent/CA2479273A1/en not_active Abandoned
- 2003-03-12 EP EP03744800A patent/EP1490348A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1490348A1 (en) | 2004-12-29 |
| AU2003227063A1 (en) | 2003-10-08 |
| WO2003080587A1 (en) | 2003-10-02 |
| MXPA04009083A (es) | 2004-12-06 |
| CA2479273A1 (en) | 2003-10-02 |
| JP2005530715A (ja) | 2005-10-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |