BR0308052A - Sais benzoato de (2's,3s)-3-hidróxi-n-{2-[n-metil-n-4-(n-propilamino-carb onil)fenil]amino-2-fenil}etilpirrolidina cristalinos anidros e mono-hidratos - Google Patents

Sais benzoato de (2's,3s)-3-hidróxi-n-{2-[n-metil-n-4-(n-propilamino-carb onil)fenil]amino-2-fenil}etilpirrolidina cristalinos anidros e mono-hidratos

Info

Publication number
BR0308052A
BR0308052A BR0308052-8A BR0308052A BR0308052A BR 0308052 A BR0308052 A BR 0308052A BR 0308052 A BR0308052 A BR 0308052A BR 0308052 A BR0308052 A BR 0308052A
Authority
BR
Brazil
Prior art keywords
phenyl
monohydrates
hydroxy
amino
methyl
Prior art date
Application number
BR0308052-8A
Other languages
English (en)
Inventor
George Joseph Quallich
Michael James Castaldi
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0308052A publication Critical patent/BR0308052A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"SAIS BENZOATO DE (2<39>S,3S)-3-HIDRóXI-N-{2-[N-METIL-N-4-(N-PROPILAMINO-CA RBONIL)FENIL]AMINO-2-FENIL}ETIL-PIRROLIDINA CRISTALINOS ANIDROS E MONO-HIDRATOS". A presente invenção refere-se a um processo de preparação de um sal benzoato anidro na forma cristalina possuindo a fórmula I: e o correspondente mono-hidrato de benzoato na forma cristalina. Os sais benzoato e suas composições farmacêuticas são agonistas de receptor capa seletivos, e são úteis como agentes analgésicos, anestésicos, antiinflamatórios ou neuroprotetores, ou no tratamento da artrite, derrame cerebral ou doença funcional do intestino.
BR0308052-8A 2002-02-28 2003-02-17 Sais benzoato de (2's,3s)-3-hidróxi-n-{2-[n-metil-n-4-(n-propilamino-carb onil)fenil]amino-2-fenil}etilpirrolidina cristalinos anidros e mono-hidratos BR0308052A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36025002P 2002-02-28 2002-02-28
PCT/IB2003/000560 WO2003072544A1 (en) 2002-02-28 2003-02-17 Crystalline anhydrous and monohydrate benzoate salts of (2's,3s)-3-hydroxy-n-{2{n-methyl-n-4-(n-propylamino-carbonyl)phenyl]amino-2-phenyl}-ethylpyrrolidine

Publications (1)

Publication Number Publication Date
BR0308052A true BR0308052A (pt) 2004-12-28

Family

ID=27766206

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308052-8A BR0308052A (pt) 2002-02-28 2003-02-17 Sais benzoato de (2's,3s)-3-hidróxi-n-{2-[n-metil-n-4-(n-propilamino-carb onil)fenil]amino-2-fenil}etilpirrolidina cristalinos anidros e mono-hidratos

Country Status (8)

Country Link
US (1) US7038061B2 (pt)
EP (1) EP1478622A1 (pt)
JP (1) JP2005519084A (pt)
AU (1) AU2003248351A1 (pt)
BR (1) BR0308052A (pt)
CA (1) CA2477634A1 (pt)
MX (1) MXPA04008352A (pt)
WO (1) WO2003072544A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003269399A1 (en) * 2002-11-01 2004-05-25 Pfizer Products Inc. Process for the preparation of pyrrolidinyl ethylamine compounds via a copper-mediated aryl amination

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TNSN97092A1 (ar) * 1996-09-18 1999-12-31 Agouron Pharma مثبطات انزيم بروتيني فلزي وتركيبات صيدلانية تحتوي على تلك المثبتطات واستخدامها الصيدلاني وطرق ومركبات وسيطة مفيدة لتحضير التركيبات المذكورة.
AU2002247886A1 (en) * 2001-04-30 2002-11-11 Pfizer Products Inc. Process for preparing hydroxypyrrolidinyl ethylamine compounds useful as kappa agonists

Also Published As

Publication number Publication date
JP2005519084A (ja) 2005-06-30
AU2003248351A1 (en) 2003-09-09
EP1478622A1 (en) 2004-11-24
MXPA04008352A (es) 2004-11-26
WO2003072544A1 (en) 2003-09-04
US7038061B2 (en) 2006-05-02
US20040235936A1 (en) 2004-11-25
CA2477634A1 (en) 2003-09-04

Similar Documents

Publication Publication Date Title
FR2868777A1 (fr) Nouveau procede de synthese de l&#39;ivabradine et de ses sels d&#39;addition a un acide pharmaceutiquement acceptable
BRPI0407262A (pt) Derivados de malonamida como inibidores gama-secretase
HRP20160808T4 (hr) Kristalni paptidi epoksiketona kao inhibitori proteaze i sinteza ketoepoksidnih aminokiselina
BR0210711A (pt) Uso de um composto, composição farmacêutica, composto, e, processo para a preparação de um composto
BR0314611A (pt) Compostos de tiazol para o tratamento de distúrbios neurodegenerativos
BRPI0011324B8 (pt) agonistas de adrenoceptores beta 2, processo de preparação dos mesmos, seu uso e composição farmacêutica compreendendo os mesmos
PT1326613E (pt) Utilizacao de derivados de imidazo[1,2-a]piridin-,imidazo[1,2-a]pirimidin- e imidazo[1,2-a]pirazin-3-il-amina substituidos para a fabricacao de medicamentos para inibicao de nos
GT200500060A (es) Compuestos de imidazol para el tratamiento de trastornos neurodegenerativos
BRPI0811280B8 (pt) compostos amino-heterocíclicos, composição farmacêutica que os compreende e usos dos referidos compostos
BR0210384A (pt) Heteroarilas multicìclicas substituìdas por quinuclidinas para o tratamento de doença
BRPI0416656A (pt) compostos de pirrolopirimidina úteis no tratamento do cáncer
AR033635A1 (es) Sales tartrato de 5,8,14-triazatetraciclo (10.3.1.0 2,11.0 4,9)-exadeca--2(11),3,5,7,9-pentaeno y composiciones farmaceuticas de las mismas.
BRPI0409624A (pt) 2-hidróxi-3-diaminoalcanos de benzamida
BRPI0415683A (pt) inibidores da reabsorção de norepinefrina para o tratamento de distúrbios do sistema nervoso central
BRPI0413245A (pt) compostos heteroarila de 6 membros para o tratamento de distúrbio neurodegenerativos
EA200870302A1 (ru) 1,3-диоксанкарбоновые кислоты
BRPI0507334A (pt) processo para a preparação de -1(2s,3s)-2-benzidril-n-(5-terc-butil-2-metoxibenzila)q uinuclidin-3-amina
BRPI0411891A (pt) pirazol[3,4-b]piridin-6-onas como inibidores de gsk-3
BRPI0413709A (pt) compostos para o tratamento de distúrbios neurodegenerativos
BRPI0411122A (pt) pirazol[3,4-b]piridin-6-onas como inibidores gsk-3
BR0313727A (pt) Derivados de isoquinolina como inibidores de metaloproteinase da matriz
DE602007013040D1 (de) 4-Ä(3-FLUORPHENOXY)PHENYLMETHYLÜPIPERIDINMETHANiSULFONAT: VERWENDUNGEN, SYNTHESEVERFAHREN UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN
CY1110401T1 (el) Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων
DK1670903T3 (da) Behandling af neurodegenerative sygdomme
BR0308052A (pt) Sais benzoato de (2&#39;s,3s)-3-hidróxi-n-{2-[n-metil-n-4-(n-propilamino-carb onil)fenil]amino-2-fenil}etilpirrolidina cristalinos anidros e mono-hidratos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 5A., 6A., E 7A., ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.