BR0306038A - Processo para preparar sondas de oligonucleotìdeos conjugados com proteìnas de albuminas - Google Patents
Processo para preparar sondas de oligonucleotìdeos conjugados com proteìnas de albuminasInfo
- Publication number
- BR0306038A BR0306038A BR0306038-1A BR0306038A BR0306038A BR 0306038 A BR0306038 A BR 0306038A BR 0306038 A BR0306038 A BR 0306038A BR 0306038 A BR0306038 A BR 0306038A
- Authority
- BR
- Brazil
- Prior art keywords
- oligonucleotide probes
- albumin protein
- conjugated oligonucleotide
- protein conjugated
- oligonucleotide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSO PARA PREPARAR SONDAS DE OLIGONUCLEOTìDEOS CONJUGADOS COM PROTEìNAS DE ALBUMINAS". A presente invenção refere-se a uma técnica para formar conjugados de proteínas e oligonucleotídeos, cuja conjugação é realizada enquanto o oligonucleotídeo está afixado ao meio de suporte, tais como pérolas de vidro. O produto conjugado pode ser então facilmente removido do meio de suporte. Descreve-se também os produtos conjugados formados por esta técnica. A presente invenção é particularmente direcionada para conjugados de proteínas de albumina, e especificamente, albumina sérica bovina (BSA).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/323,385 US6913890B2 (en) | 2002-12-18 | 2002-12-18 | Process for preparing albumin protein conjugated oligonucleotide probes |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0306038A true BR0306038A (pt) | 2004-08-17 |
Family
ID=32593199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0306038-1A BR0306038A (pt) | 2002-12-18 | 2003-12-17 | Processo para preparar sondas de oligonucleotìdeos conjugados com proteìnas de albuminas |
Country Status (2)
Country | Link |
---|---|
US (2) | US6913890B2 (pt) |
BR (1) | BR0306038A (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US20040010134A1 (en) * | 2000-04-12 | 2004-01-15 | Rosen Craig A. | Albumin fusion proteins |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7507413B2 (en) * | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
WO2003059934A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DK1463751T3 (da) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albuminfusionsproteiner. |
US7906630B2 (en) * | 2004-04-27 | 2011-03-15 | PerkinElmer Heath Sciences, Inc. | Method for identifying peptides in a biological sample |
CN102181550B (zh) * | 2011-04-18 | 2014-07-09 | 深圳康美生物科技股份有限公司 | 一种检测多种病原微生物的方法和试剂盒 |
DK2972353T3 (da) * | 2013-03-11 | 2023-03-27 | Meso Scale Technologies Llc | Forbedrede fremgangsmåder til udførelse af multipleksanalyser |
US10478503B2 (en) | 2016-01-31 | 2019-11-19 | University Of Massachusetts | Branched oligonucleotides |
WO2018031933A2 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
MX2021001590A (es) | 2018-08-10 | 2021-07-02 | Univ Massachusetts | Oligonucleótidos modificados dirigidos a snp. |
US11492619B2 (en) | 2019-01-18 | 2022-11-08 | University Of Massachusetts | Dynamic pharmacokinetic-modifying anchors |
WO2022271786A1 (en) | 2021-06-23 | 2022-12-29 | University Of Massachusetts | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935494A (en) * | 1988-11-15 | 1990-06-19 | City Of Hope | C-terminal peptide and protein sequencing |
US5578718A (en) * | 1990-01-11 | 1996-11-26 | Isis Pharmaceuticals, Inc. | Thiol-derivatized nucleosides |
EP0537299A1 (en) | 1990-03-29 | 1993-04-21 | Gilead Sciences, Inc. | Oligonucleotide-transport agent disulfide conjugates |
US5218105A (en) * | 1990-07-27 | 1993-06-08 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
EP1331011A3 (en) | 1991-10-24 | 2003-12-17 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
US5767238A (en) * | 1995-06-07 | 1998-06-16 | Combichem, Inc. | Inverse solid phase synthesis |
EP0844252A3 (en) * | 1996-11-15 | 1998-07-08 | Remacle, José | Cyclic peptides bearing a tail designed for subsequent chemical coupling and process for preparing same |
US5837466A (en) * | 1996-12-16 | 1998-11-17 | Vysis, Inc. | Devices and methods for detecting nucleic acid analytes in samples |
US5977299A (en) * | 1997-04-07 | 1999-11-02 | Dade Behring Marburg Gmbh | Activated peptides and conjugates |
AU741546B2 (en) | 1997-07-24 | 2001-12-06 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
US6210908B1 (en) * | 1998-11-11 | 2001-04-03 | Dade Behring Marburg Gmbh | Activated peptides and conjugates |
US6255476B1 (en) * | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
US6656730B1 (en) * | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
US6911535B2 (en) * | 2000-03-22 | 2005-06-28 | Solvlink Biosciences | Biomolecule/polymer conjugates |
US20020068818A1 (en) * | 2000-08-09 | 2002-06-06 | Vince Pozsgay | Conjugation of biomolecules using diels-alder cycloaddition |
US6673905B2 (en) * | 2000-08-09 | 2004-01-06 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugation of biomolecules using Diels-Alder cycloaddition |
US6559279B1 (en) | 2000-09-08 | 2003-05-06 | Isis Pharmaceuticals, Inc. | Process for preparing peptide derivatized oligomeric compounds |
US20040038331A1 (en) * | 2002-08-23 | 2004-02-26 | Reddy M. Parameswara | Solid phase synthesis of biomolecule conjugates |
-
2002
- 2002-12-18 US US10/323,385 patent/US6913890B2/en not_active Expired - Fee Related
-
2003
- 2003-12-17 BR BR0306038-1A patent/BR0306038A/pt active Search and Examination
-
2005
- 2005-07-01 US US11/173,635 patent/US7538192B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050244884A1 (en) | 2005-11-03 |
US20040121426A1 (en) | 2004-06-24 |
US7538192B2 (en) | 2009-05-26 |
US6913890B2 (en) | 2005-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |