BR0207521A - Antagonistas rotulados de receptores de removedores macrófagos para a geração de imagens de aterosclerose e placa vulnerável - Google Patents
Antagonistas rotulados de receptores de removedores macrófagos para a geração de imagens de aterosclerose e placa vulnerávelInfo
- Publication number
- BR0207521A BR0207521A BR0207521-0A BR0207521A BR0207521A BR 0207521 A BR0207521 A BR 0207521A BR 0207521 A BR0207521 A BR 0207521A BR 0207521 A BR0207521 A BR 0207521A
- Authority
- BR
- Brazil
- Prior art keywords
- atherosclerosis
- vulnerable plaque
- receptor antagonists
- macrophage scavenger
- scavenger receptor
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title abstract 3
- 108091005485 macrophage scavenger receptors Proteins 0.000 title abstract 2
- 102000014452 scavenger receptors Human genes 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 206010053159 Organ failure Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 210000002540 macrophage Anatomy 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27095401P | 2001-02-23 | 2001-02-23 | |
| PCT/US2002/005156 WO2002067761A2 (en) | 2001-02-23 | 2002-02-22 | Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207521A true BR0207521A (pt) | 2004-06-01 |
Family
ID=23033552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207521-0A BR0207521A (pt) | 2001-02-23 | 2002-02-22 | Antagonistas rotulados de receptores de removedores macrófagos para a geração de imagens de aterosclerose e placa vulnerável |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6869590B2 (enExample) |
| EP (1) | EP1377321A4 (enExample) |
| JP (1) | JP2004530654A (enExample) |
| CN (1) | CN1622832A (enExample) |
| AU (1) | AU2002254000A1 (enExample) |
| BR (1) | BR0207521A (enExample) |
| CA (1) | CA2438174A1 (enExample) |
| CZ (1) | CZ20032564A3 (enExample) |
| HU (1) | HUP0400027A3 (enExample) |
| IL (1) | IL157444A0 (enExample) |
| MX (1) | MXPA03007534A (enExample) |
| WO (1) | WO2002067761A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03010035A (es) * | 2001-05-02 | 2004-06-30 | Purdue Research Foundation | Tratamiento y diagnostico de enfermedades mediadas por macrofagos. |
| CA2449828A1 (en) * | 2001-06-04 | 2003-01-16 | The General Hospital Corporation | Detection and therapy of vulnerable plaque with photodynamic compounds |
| CA2461836A1 (en) * | 2001-10-16 | 2003-04-24 | Epix Medical, Inc. | Detection and treatment of intravascular lesions |
| US8043603B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| AU2002337926B8 (en) * | 2002-11-05 | 2008-02-28 | Ion Beam Applications S.A. | Stabilization of radiopharmaceuticals labeled with 18-F |
| US7018614B2 (en) * | 2002-11-05 | 2006-03-28 | Eastern Isotopes, Inc. | Stabilization of radiopharmaceuticals labeled with 18-F |
| GB0228490D0 (en) * | 2002-12-06 | 2003-01-08 | Amersham Plc | Novel imaging compounds |
| US7297154B2 (en) | 2003-02-24 | 2007-11-20 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
| US7153299B1 (en) | 2003-02-24 | 2006-12-26 | Maxwell Sensors Inc. | Optical apparatus for detecting and treating vulnerable plaque |
| US7803352B2 (en) * | 2003-03-07 | 2010-09-28 | John Steele Fisher | Method for continuous visualization of a blood clot or plaque in body lumen |
| JP4680185B2 (ja) | 2003-05-30 | 2011-05-11 | パーデュー・リサーチ・ファウンデーション | アテローム性動脈硬化症の診断法 |
| CN1859904A (zh) * | 2003-10-03 | 2006-11-08 | 默克公司 | 用于治疗阿尔茨海默氏病的苄醚和苄氨基β－分泌酶抑制剂 |
| EP1602931A1 (en) * | 2004-06-03 | 2005-12-07 | Universiteit Leiden | SR-A antagonists |
| US20080206150A1 (en) * | 2004-06-25 | 2008-08-28 | The Regents Of The University Of California | Nanoparticles for Imaging Atherosclerotic Plaque |
| US7575738B2 (en) | 2004-08-13 | 2009-08-18 | General Electric Company | Heat shock protein as a targeting agent for endothelium-specific in vivo transduction |
| RU2007128036A (ru) * | 2004-12-23 | 2009-01-27 | Пердью Рисерч Фаундейшн (Us) | Способ получения изображения позитронно-эмиссионной томографией |
| EP1904183B1 (en) | 2005-07-05 | 2014-10-15 | Purdue Research Foundation | Pharmaceutical composition for the treatment of osteoarthritis |
| US7874975B2 (en) * | 2005-07-20 | 2011-01-25 | Clear Vascular, Inc. | Methods and compositions for treating luminal inflammatory disease |
| WO2007038346A2 (en) | 2005-09-23 | 2007-04-05 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US20070196282A1 (en) * | 2006-02-21 | 2007-08-23 | Siemens Medical Solutions Usa, Inc. | Medical diagnostic ultrasound with temperature-dependent contrast agents |
| EP2087337A4 (en) | 2006-11-03 | 2010-09-08 | Purdue Research Foundation | METHOD AND DEVICE FOR EX-VIVO FLOW CYTOMETRY |
| EP2109466B1 (en) | 2007-02-07 | 2014-11-12 | Purdue Research Foundation | Positron emission tomography imaging method |
| US8961926B2 (en) * | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| RU2474435C2 (ru) * | 2007-11-07 | 2013-02-10 | Джи-И Хелткер БВ | Стабилизация радиофармацевтических композиций |
| US9717896B2 (en) | 2007-12-18 | 2017-08-01 | Gearbox, Llc | Treatment indications informed by a priori implant information |
| US20090287120A1 (en) | 2007-12-18 | 2009-11-19 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Circulatory monitoring systems and methods |
| US8636670B2 (en) | 2008-05-13 | 2014-01-28 | The Invention Science Fund I, Llc | Circulatory monitoring systems and methods |
| US8361438B2 (en) * | 2008-01-08 | 2013-01-29 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
| EP2451776B1 (en) | 2009-07-08 | 2019-09-18 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| US20150023873A1 (en) | 2011-11-11 | 2015-01-22 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| DE112016001921B4 (de) | 2015-06-09 | 2025-03-20 | Cummins Filtration Ip, Inc. | Kurbelgehäuseentlüftungssysteme, die rotierende Tropfenabscheidervorrichtungen verwenden |
| WO2019034500A1 (en) * | 2017-08-15 | 2019-02-21 | Koninklijke Philips N.V. | INTRALUMINAL ULTRASONIC DEVICE WITH ADJUSTABLE FREQUENCY |
| US10933146B2 (en) * | 2017-12-12 | 2021-03-02 | Massachusetts Institute Of Technology | Cell-permeable imaging sensors and uses thereof |
| KR102207372B1 (ko) * | 2020-03-31 | 2021-01-27 | 재단법인 아산사회복지재단 | 방사성 의약품의 안정화제 및 이를 포함하는 방사성 의약 조성물 |
| CN116473020B (zh) * | 2022-11-18 | 2025-04-25 | 新乡医学院 | 一种Macrosialin基因缺失动脉粥样硬化小鼠模型的构建方法及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4577042A (en) * | 1983-03-17 | 1986-03-18 | California Institute Of Technology | Homogeneous coordination compounds as oxidation catalysts |
| US4678667A (en) | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
| US4752141A (en) | 1985-10-25 | 1988-06-21 | Luxtron Corporation | Fiberoptic sensing of temperature and/or other physical parameters |
| EP0247156B1 (en) | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| MX174467B (es) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
| US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| GB8603537D0 (en) | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
| GB8719042D0 (en) | 1987-08-12 | 1987-09-16 | Parker D | Conjugate compounds |
| US4923985A (en) | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| EP0416033B1 (en) | 1988-05-25 | 1996-03-06 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Macrocyclic chelates and methods of use thereof |
| US5756065A (en) | 1988-06-24 | 1998-05-26 | The Dow Chemical Company | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents |
| LU87403A1 (fr) | 1988-12-06 | 1990-07-10 | Oreal | Procede de teinture de fibres keratiniques avec un hydroxyindole,associe a un derive quinonique |
| DE69024826T2 (de) | 1989-02-10 | 1996-06-27 | Celltech Therapeutics Ltd | Aza-Macrozyklen und Verfahren zu deren Herstellung |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US4986671A (en) | 1989-04-12 | 1991-01-22 | Luxtron Corporation | Three-parameter optical fiber sensor and system |
| US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| AU7587091A (en) | 1990-03-26 | 1991-10-21 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | A fonctionalized complexand |
| US5275594A (en) | 1990-11-09 | 1994-01-04 | C. R. Bard, Inc. | Angioplasty system having means for identification of atherosclerotic plaque |
| EP0565930A1 (en) | 1992-03-27 | 1993-10-20 | Nihon Medi-Physics Co., Ltd. | Tetraazacyclododecane tetraacetic acid derivatives and the use thereof as diagnostic agents |
| US5310535A (en) | 1992-04-24 | 1994-05-10 | The Dow Chemical Company | Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies |
| US5744120A (en) | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
| US5428156A (en) | 1993-04-02 | 1995-06-27 | Associated Universities, Inc. | Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging |
| AU2194695A (en) | 1994-03-28 | 1995-10-17 | Regents Of The University Of California, The | Method for preparing radionuclide-labeled chelating agent-ligand complexes |
| IT1283218B1 (it) | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| US5879659A (en) | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
| US5848367A (en) | 1996-09-13 | 1998-12-08 | Sony Corporation | System and method for sharing a non-volatile memory element as a boot device |
| US6403054B1 (en) | 1997-05-28 | 2002-06-11 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
| WO1999007382A1 (en) | 1997-08-06 | 1999-02-18 | Smithkline Beecham Corporation | Macrophage scavenger receptor antagonists for use in the treatment of cardiovascular diseases |
| CA2328457A1 (en) | 1998-06-20 | 1999-12-29 | Washington University | Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy |
| WO2000003704A1 (en) * | 1998-07-20 | 2000-01-27 | Smithkline Beecham Corporation | Macrophage scavenger receptor antagonists |
| JP2002521437A (ja) | 1998-07-30 | 2002-07-16 | スミスクライン・ビーチャム・コーポレイション | マクロファージ・スカベンジャー受容体アンタゴニスト |
-
2002
- 2002-02-22 JP JP2002567138A patent/JP2004530654A/ja active Pending
- 2002-02-22 MX MXPA03007534A patent/MXPA03007534A/es active IP Right Grant
- 2002-02-22 AU AU2002254000A patent/AU2002254000A1/en not_active Abandoned
- 2002-02-22 EP EP02723207A patent/EP1377321A4/en not_active Withdrawn
- 2002-02-22 IL IL15744402A patent/IL157444A0/xx unknown
- 2002-02-22 BR BR0207521-0A patent/BR0207521A/pt not_active IP Right Cessation
- 2002-02-22 CA CA002438174A patent/CA2438174A1/en not_active Abandoned
- 2002-02-22 CN CNA028087704A patent/CN1622832A/zh active Pending
- 2002-02-22 CZ CZ20032564A patent/CZ20032564A3/cs unknown
- 2002-02-22 WO PCT/US2002/005156 patent/WO2002067761A2/en not_active Ceased
- 2002-02-22 HU HU0400027A patent/HUP0400027A3/hu unknown
- 2002-02-22 US US10/080,974 patent/US6869590B2/en not_active Expired - Fee Related
-
2003
- 2003-08-14 US US10/641,688 patent/US6974567B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL157444A0 (en) | 2004-03-28 |
| AU2002254000A1 (en) | 2002-09-12 |
| JP2004530654A (ja) | 2004-10-07 |
| EP1377321A2 (en) | 2004-01-07 |
| US6974567B2 (en) | 2005-12-13 |
| US20040057900A1 (en) | 2004-03-25 |
| MXPA03007534A (es) | 2003-12-04 |
| CA2438174A1 (en) | 2002-09-06 |
| US20020127181A1 (en) | 2002-09-12 |
| HUP0400027A2 (hu) | 2004-04-28 |
| US6869590B2 (en) | 2005-03-22 |
| CZ20032564A3 (cs) | 2004-09-15 |
| WO2002067761A2 (en) | 2002-09-06 |
| EP1377321A4 (en) | 2006-01-11 |
| WO2002067761A3 (en) | 2003-02-13 |
| HUP0400027A3 (en) | 2006-01-30 |
| CN1622832A (zh) | 2005-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADE(S). |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |