BR0206386A - Ativador ligado a suporte, suporte ativado, kit, biblioteca de alvos ativados pelo suporte, suporte fortemente ácido, suporte sililador, método de fixar covalentemente um nucleófilo a um composto apresentando um grupo hidróxi ou uma cetona enolizável, e, reagente ligador - Google Patents

Ativador ligado a suporte, suporte ativado, kit, biblioteca de alvos ativados pelo suporte, suporte fortemente ácido, suporte sililador, método de fixar covalentemente um nucleófilo a um composto apresentando um grupo hidróxi ou uma cetona enolizável, e, reagente ligador

Info

Publication number
BR0206386A
BR0206386A BR0206386-7A BR0206386A BR0206386A BR 0206386 A BR0206386 A BR 0206386A BR 0206386 A BR0206386 A BR 0206386A BR 0206386 A BR0206386 A BR 0206386A
Authority
BR
Brazil
Prior art keywords
support
activated
kit
compound
nucleophile
Prior art date
Application number
BR0206386-7A
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher Holmes
Yijum Pan
Original Assignee
Amersham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Plc filed Critical Amersham Plc
Publication of BR0206386A publication Critical patent/BR0206386A/pt

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    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/34—Introducing sulfur atoms or sulfur-containing groups
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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
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    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J31/1658—Polymer immobilised coordination complexes, e.g. organometallic complexes immobilised by covalent linkages, i.e. pendant complexes with optional linking groups, e.g. on Wang or Merrifield resins
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C309/07—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/10—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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    • B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
    • B01J2231/4261—Heck-type, i.e. RY + C=C, in which R is aryl
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
    • B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
    • B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
    • B01J2231/4266—Sonogashira-type, i.e. RY + HC-CR' triple bonds, in which R=aryl, alkenyl, alkyl and R'=H, alkyl or aryl
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
    • B01J2531/80—Complexes comprising metals of Group VIII as the central metal
    • B01J2531/82—Metals of the platinum group
    • B01J2531/824—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/22—Organic complexes
    • B01J31/2204—Organic complexes the ligands containing oxygen or sulfur as complexing atoms
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
    • B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
    • B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
    • B01J31/2409—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring with more than one complexing phosphine-P atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

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  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
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BR0206386-7A 2001-01-12 2002-01-11 Ativador ligado a suporte, suporte ativado, kit, biblioteca de alvos ativados pelo suporte, suporte fortemente ácido, suporte sililador, método de fixar covalentemente um nucleófilo a um composto apresentando um grupo hidróxi ou uma cetona enolizável, e, reagente ligador BR0206386A (pt)

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EP1491888B1 (en) * 2002-04-03 2008-09-17 Mitsubishi Rayon Co., Ltd. Microarray comprising gel having biosubstance fixed thereto as well as manufacture and use thereof
GB0317920D0 (en) 2003-07-31 2003-09-03 Amersham Plc Solid-phase synthesis
RU2380685C1 (ru) * 2008-11-07 2010-01-27 Шлюмберже Текнолоджи Б.В. Эталонный материал с порами контролируемого размера и формы и блок из фрагментов эталонного материала с порами контролируемого размера и формы
WO2012018709A2 (en) * 2010-08-06 2012-02-09 Arkema Inc. Superacid functional compounds
EP3142709B1 (en) * 2014-05-15 2025-07-30 Mayo Foundation for Medical Education and Research Synthesis sytem comprising a solution target for cyclotron production of radiometals and associated method
JP6912576B2 (ja) * 2016-12-30 2021-08-04 ダウ グローバル テクノロジーズ エルエルシー 促進剤および酸化防止剤を含む樹脂
CN116445941A (zh) * 2023-04-28 2023-07-18 湖南法恩莱特新能源科技有限公司 含氟磺酸酯的制备方法及其电解液和电化学装置
CN116554386B (zh) * 2023-07-07 2023-09-29 国家电投集团氢能科技发展有限公司 全氟磺酰氟树脂的酯化方法和全氟磺酸树脂的制备方法
CN120329653B (zh) * 2025-05-19 2025-11-25 揭阳市恭发塑胶有限公司 一种安全抗菌pp材料及制备方法

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US20110028751A1 (en) 2011-02-03
US7700524B2 (en) 2010-04-20
AU2002246986B2 (en) 2006-11-09
CA2434570A1 (en) 2002-07-18
WO2002055026A2 (en) 2002-07-18
HUP0303192A2 (hu) 2003-12-29
CN1524181A (zh) 2004-08-25
WO2002055026A3 (en) 2002-11-14
KR20030078069A (ko) 2003-10-04
RU2003121311A (ru) 2005-02-27
CN100480701C (zh) 2009-04-22
MXPA03006228A (es) 2004-12-06
IL156677A0 (en) 2004-01-04
ZA200305099B (en) 2005-01-26
EP1352243A2 (en) 2003-10-15
US20030124612A1 (en) 2003-07-03
RU2291146C2 (ru) 2007-01-10
EP1352243A4 (en) 2008-07-02
JP4349559B2 (ja) 2009-10-21
US20040106151A1 (en) 2004-06-03
JP2005501798A (ja) 2005-01-20

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