BR0115457A - Lâmina de material adaptada para implante entre tecidos de um corpo humano, método para diminuição da formação de tecido de cicatrização após um procedimento cirúrgico e método para diminuição da formação de tecido de cicatrização em um corte na pele de um indivìduo - Google Patents

Lâmina de material adaptada para implante entre tecidos de um corpo humano, método para diminuição da formação de tecido de cicatrização após um procedimento cirúrgico e método para diminuição da formação de tecido de cicatrização em um corte na pele de um indivìduo

Info

Publication number
BR0115457A
BR0115457A BR0115457-5A BR0115457A BR0115457A BR 0115457 A BR0115457 A BR 0115457A BR 0115457 A BR0115457 A BR 0115457A BR 0115457 A BR0115457 A BR 0115457A
Authority
BR
Brazil
Prior art keywords
formation
tissue formation
scar tissue
tissues
antiproliferative
Prior art date
Application number
BR0115457-5A
Other languages
English (en)
Inventor
Robert E Fischell
David R Fischell
Tim A Fischell
Scott J S Fischell
Original Assignee
Afmedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Afmedica Inc filed Critical Afmedica Inc
Publication of BR0115457A publication Critical patent/BR0115457A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06166—Sutures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00365—Plasters use
    • A61F2013/00451—Plasters use for surgical sutures, e.g. butterfly type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424—Anti-adhesion agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622—Microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/626—Liposomes, micelles, vesicles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)

Abstract

"LâMINA DE MATERIAL ADAPTADA PARA IMPLANTE ENTRE TECIDOS DE UM CORPO HUMANO, MéTODO PARA DIMINUIçãO DA FORMAçãO DE TECIDO DE CICATRIZAçãO APóS UM PROCEDIMENTO CIRúRGICO E MéTODO PARA DIMINUIçãO DA FORMAçãO DE TECIDO DE CICATRIZAçãO EM UM CORTE NA PELE DE UM INDIVìDUO". Sendo que a presente invenção apresenta um medicamento antiproliferativo aplicado em ou dentro de uma lâmina estéril ou rede que é projetada para ser colocada entre os tecidos internos do corpo a fim de prevenir a formação de aderências pós-operatórias, cujas aderências são de formação de tecido de cicatrização. Essa rede ou gaze em ou dentro do qual o medicamento é aplicado pode ser tanto um implante permanente como pode ser biodegradável. Ao impregnar um produto existente como a lâmina semelhante a gaze de hemostato absorvível SURGICEL^ TM^ da Johnson&Johnson com um medicamento antiproliferativo, por exemplo, Rapamicina ou Taxol, a rede impregnada pelo medicamento biodegradável agiria como uma barreira para a proliferação celular e por esta razão seria um impedimento para a formação de aderências. Uma outra realização dessa invenção consiste em um medicamento antiproliferativo aplicado em uma bandagem que é disposta em um corte na pele a fim de diminuir a formação do tecido de cicatrização. Ainda uma outra realização da invenção consiste em um medicamento antiproliferativo que é aplicado em uma sutura cirúrgica ou revestido em um grampo cirúrgico, ambos são utilizados para a conexão dos tecidos humanos. A sutura ou grampo é, então, mais capaz de diminuir a proliferação celular em que a sutura ou o material de grampo passa através do tecido humano.
BR0115457-5A 2000-11-06 2001-10-16 Lâmina de material adaptada para implante entre tecidos de um corpo humano, método para diminuição da formação de tecido de cicatrização após um procedimento cirúrgico e método para diminuição da formação de tecido de cicatrização em um corte na pele de um indivìduo BR0115457A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70599900A 2000-11-06 2000-11-06
PCT/US2001/027771 WO2002036054A1 (en) 2000-11-06 2001-10-16 Surgically implanted devices having reduced scar tissue

Publications (1)

Publication Number Publication Date
BR0115457A true BR0115457A (pt) 2004-06-15

Family

ID=24835796

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115457-5A BR0115457A (pt) 2000-11-06 2001-10-16 Lâmina de material adaptada para implante entre tecidos de um corpo humano, método para diminuição da formação de tecido de cicatrização após um procedimento cirúrgico e método para diminuição da formação de tecido de cicatrização em um corte na pele de um indivìduo

Country Status (8)

Country Link
US (3) US6534693B2 (pt)
EP (1) EP1385458A4 (pt)
JP (1) JP2004529667A (pt)
AU (2) AU2002224318B2 (pt)
BR (1) BR0115457A (pt)
CA (1) CA2428082A1 (pt)
MX (1) MXPA03003906A (pt)
WO (1) WO2002036054A1 (pt)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795242B2 (en) * 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
DE69734060T2 (de) * 1996-05-24 2006-06-29 Angiotech Pharmaceuticals, Inc., Vancouver Zubereitungen und verfahren zur behandlung oder prävention von krankheiten der körperpassagewege
US7209787B2 (en) * 1998-08-05 2007-04-24 Bioneuronics Corporation Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US9375573B2 (en) 1998-08-05 2016-06-28 Cyberonics, Inc. Systems and methods for monitoring a patient's neurological disease state
US9320900B2 (en) * 1998-08-05 2016-04-26 Cyberonics, Inc. Methods and systems for determining subject-specific parameters for a neuromodulation therapy
US9415222B2 (en) 1998-08-05 2016-08-16 Cyberonics, Inc. Monitoring an epilepsy disease state with a supervisory module
US7974696B1 (en) 1998-08-05 2011-07-05 Dilorenzo Biomedical, Llc Closed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease
US8762065B2 (en) * 1998-08-05 2014-06-24 Cyberonics, Inc. Closed-loop feedback-driven neuromodulation
US9042988B2 (en) 1998-08-05 2015-05-26 Cyberonics, Inc. Closed-loop vagus nerve stimulation
US7231254B2 (en) * 1998-08-05 2007-06-12 Bioneuronics Corporation Closed-loop feedback-driven neuromodulation
US7403820B2 (en) * 1998-08-05 2008-07-22 Neurovista Corporation Closed-loop feedback-driven neuromodulation
US7747325B2 (en) * 1998-08-05 2010-06-29 Neurovista Corporation Systems and methods for monitoring a patient's neurological disease state
US7277758B2 (en) * 1998-08-05 2007-10-02 Neurovista Corporation Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US6955661B1 (en) * 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6616876B1 (en) 2000-10-03 2003-09-09 Atrium Medical Corporation Method for treating expandable polymer materials
US6923927B2 (en) 2000-10-03 2005-08-02 Atrium Medical Corporation Method for forming expandable polymers having drugs or agents included therewith
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
US20040241211A9 (en) * 2000-11-06 2004-12-02 Fischell Robert E. Devices and methods for reducing scar tissue formation
AU2002249958B2 (en) * 2001-01-16 2007-11-08 Vascular Therapies, Inc. Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
US6629988B2 (en) * 2001-08-28 2003-10-07 Ethicon, Inc. Composite staple for completing an anastomosis
AU2003209297A1 (en) * 2002-01-18 2003-09-02 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
US20040087613A1 (en) * 2002-01-29 2004-05-06 Molmenti Ernesto P. Prevention of adhesions with rapamycin
EP1482975B1 (en) * 2002-01-29 2006-12-13 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Prevention of tissue adhesion
EP1516597A4 (en) * 2002-06-27 2010-11-10 Microport Medical Shanghai Co MEDICINES ELUTIONSSTENT
JP2005532809A (ja) * 2002-07-16 2005-11-04 バイオチカ テクノロジー リミテッド ポリケチド、及び他の天然物の製造
US7101381B2 (en) * 2002-08-02 2006-09-05 C.R. Bard, Inc. Implantable prosthesis
AU2003272471B2 (en) 2002-09-18 2010-10-07 Trustees Of The University Of Pennsylvania Method of inhibiting choroidal neovascularization
MXPA05003238A (es) * 2002-09-26 2005-09-12 Endovascular Devices Inc Aparato y metodo para administrar mitomicina a traves de un dispositivo medico implantable biocompatible de elucion.
US20040146546A1 (en) * 2002-09-26 2004-07-29 Angiotech Pharmaceuticals, Inc. Perivascular wraps
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7354574B2 (en) * 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
AU2003293529A1 (en) 2002-12-16 2004-07-29 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
CA2511486A1 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
DE10305811A1 (de) 2003-02-12 2004-08-26 Ethicon Gmbh Chirurgisches Implantat
US20040167572A1 (en) * 2003-02-20 2004-08-26 Roth Noah M. Coated medical devices
US7083802B2 (en) * 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US8021331B2 (en) * 2003-09-15 2011-09-20 Atrium Medical Corporation Method of coating a folded medical device
EP1682132A1 (en) * 2003-09-18 2006-07-26 Macusight, Inc. Transscleral delivery
US7083803B2 (en) * 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US20050181018A1 (en) * 2003-09-19 2005-08-18 Peyman Gholam A. Ocular drug delivery
US7087237B2 (en) * 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
US20050181977A1 (en) * 2003-11-10 2005-08-18 Angiotech International Ag Medical implants and anti-scarring agents
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
US20050208095A1 (en) * 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
AU2004293463A1 (en) * 2003-11-20 2005-06-09 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US7758654B2 (en) * 2004-05-20 2010-07-20 Kensey Nash Corporation Anti-adhesion device
KR100596218B1 (ko) * 2004-06-10 2006-07-03 (주)액세스 플러스 약물이 표면처리된 혈액투석환자의 동정맥 연결용 튜브
EP3470108A1 (en) 2004-07-02 2019-04-17 Mati Therapeutics Inc. Treatment medium delivery device for delivery of treatment media to the eye
US8312836B2 (en) * 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US9592324B2 (en) 2006-11-06 2017-03-14 Atrium Medical Corporation Tissue separating device with reinforced support for anchoring mechanisms
US20090011116A1 (en) * 2004-09-28 2009-01-08 Atrium Medical Corporation Reducing template with coating receptacle containing a medical device to be coated
US20060088596A1 (en) 2004-09-28 2006-04-27 Atrium Medical Corporation Solubilizing a drug for use in a coating
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US8367099B2 (en) * 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US20060067976A1 (en) 2004-09-28 2006-03-30 Atrium Medical Corporation Formation of barrier layer
WO2006036970A2 (en) * 2004-09-28 2006-04-06 Atrium Medical Corporation Method of thickening a coating using a drug
AU2006213673A1 (en) * 2005-02-09 2006-08-17 Santen Pharmaceutical Co., Ltd. Formulations for ocular treatment
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
WO2006124838A1 (en) * 2005-05-18 2006-11-23 Gt Urological, Llc. Drug elution for implantable incontinence devices
AU2006270041B2 (en) 2005-07-18 2011-08-18 Minu, Llc Enhanced ocular neuroprotection/neurostimulation
US20070014760A1 (en) * 2005-07-18 2007-01-18 Peyman Gholam A Enhanced recovery following ocular surgery
US7592330B2 (en) * 2005-08-08 2009-09-22 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
EP1937314A4 (en) * 2005-09-01 2009-01-07 Bristol Myers Squibb Co BIOMARKERS AND PROCEDURE FOR DETERMINING SENSITIVITY FOR VASCULAR ENDOTHEL GROWTH FACTOR RECEPTOR 2 MODULATORS
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
EP1933991A4 (en) 2005-10-15 2012-05-02 Atrium Medical Corp HYDROPHOBIC NETWORKED GEL FOR BIOABSORBIBLE MEDICINAL CARRIER COVERS
US20070149952A1 (en) * 2005-12-28 2007-06-28 Mike Bland Systems and methods for characterizing a patient's propensity for a neurological event and for communicating with a pharmacological agent dispenser
US8868172B2 (en) * 2005-12-28 2014-10-21 Cyberonics, Inc. Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders
US8725243B2 (en) 2005-12-28 2014-05-13 Cyberonics, Inc. Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
EP1978930A2 (en) * 2006-01-31 2008-10-15 Angiotech Pharmaceuticals, Inc. Sutures and anti-scarring agents
CA2635797C (en) 2006-02-09 2015-03-31 Macusight, Inc. Stable formulations, and methods of their preparation and use
US20070287931A1 (en) * 2006-02-14 2007-12-13 Dilorenzo Daniel J Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
JP5506378B2 (ja) 2006-03-23 2014-05-28 参天製薬株式会社 血管透過性に関連する疾患または病気のための製剤および方法
RU2413480C2 (ru) 2006-03-31 2011-03-10 Клт Плаг Диливери, Инк. Способы доставки лекарственных средств, структуры и композиции для носослезной системы
US20080027348A1 (en) 2006-06-23 2008-01-31 Neuro Vista Corporation Minimally Invasive Monitoring Systems for Monitoring a Patient's Propensity for a Neurological Event
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US8295934B2 (en) 2006-11-14 2012-10-23 Neurovista Corporation Systems and methods of reducing artifact in neurological stimulation systems
CA2670590C (en) 2006-12-01 2018-06-12 Wake Forest University Health Sciences Medical devices incorporating collagen inhibitors
EP2124734A2 (en) 2007-01-25 2009-12-02 NeuroVista Corporation Methods and systems for measuring a subject's susceptibility to a seizure
WO2008092119A2 (en) 2007-01-25 2008-07-31 Neurovista Corporation Systems and methods for identifying a contra-ictal condition in a subject
US7938286B2 (en) * 2007-02-13 2011-05-10 Gateway Plastics, Inc. Container system
US8036736B2 (en) 2007-03-21 2011-10-11 Neuro Vista Corporation Implantable systems and methods for identifying a contra-ictal condition in a subject
US20080265343A1 (en) * 2007-04-26 2008-10-30 International Business Machines Corporation Field effect transistor with inverted t shaped gate electrode and methods for fabrication thereof
US7832611B2 (en) * 2007-05-16 2010-11-16 The Invention Science Fund I, Llc Steerable surgical stapler
US7922064B2 (en) 2007-05-16 2011-04-12 The Invention Science Fund, I, LLC Surgical fastening device with cutter
US7798385B2 (en) * 2007-05-16 2010-09-21 The Invention Science Fund I, Llc Surgical stapling instrument with chemical sealant
US7823761B2 (en) * 2007-05-16 2010-11-02 The Invention Science Fund I, Llc Maneuverable surgical stapler
US8485411B2 (en) 2007-05-16 2013-07-16 The Invention Science Fund I, Llc Gentle touch surgical stapler
US20080287987A1 (en) * 2007-05-16 2008-11-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Dispensing system for tissue sealants
US7810691B2 (en) * 2007-05-16 2010-10-12 The Invention Science Fund I, Llc Gentle touch surgical stapler
US8721711B2 (en) * 2007-06-20 2014-05-13 Oregon Health & Science University Graft having microporous membrane for uniform fluid infusion
US9788744B2 (en) 2007-07-27 2017-10-17 Cyberonics, Inc. Systems for monitoring brain activity and patient advisory device
MX2010002618A (es) * 2007-09-07 2010-11-10 Qlt Plug Delivery Inc Herramientas de insercion y extraccion para implantes lagrimales.
NZ583678A (en) * 2007-09-07 2012-03-30 Quadra Logic Tech Inc Silicone matrix drug cores for sustained release of therapeutic agents
MX2010002619A (es) 2007-09-07 2010-06-01 Qlt Plug Delivery Inc Deteccion de implante lagrimal.
US20090112243A1 (en) * 2007-10-25 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Surgical cutter with dispensing system for tissue sealants
US20090112256A1 (en) * 2007-10-30 2009-04-30 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Suturing device with tissue sealant dispenser
US20090143816A1 (en) * 2007-11-30 2009-06-04 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Grasper with surgical sealant dispenser
US8808255B2 (en) * 2007-12-14 2014-08-19 Oregon Health & Science University Drug delivery cuff
US9259591B2 (en) 2007-12-28 2016-02-16 Cyberonics, Inc. Housing for an implantable medical device
US20090171168A1 (en) 2007-12-28 2009-07-02 Leyde Kent W Systems and Method for Recording Clinical Manifestations of a Seizure
US10376261B2 (en) * 2008-04-01 2019-08-13 Covidien Lp Anchoring suture
WO2009134371A2 (en) * 2008-04-30 2009-11-05 Qlt Plug Delivery, Inc. Composite lacrimal insert and related methods
JP2011520805A (ja) * 2008-05-09 2011-07-21 キューエルティー プラグ デリバリー，インク． 緑内障および高眼圧症治療のための活性剤の持続送達
TW201012469A (en) * 2008-06-24 2010-04-01 Qlt Plug Delivery Inc Combination treatment of glaucoma
KR101062068B1 (ko) * 2008-12-01 2011-09-02 포항공과대학교 산학협력단 유착방지용 조성물
US8849390B2 (en) 2008-12-29 2014-09-30 Cyberonics, Inc. Processing for multi-channel signals
US8588933B2 (en) 2009-01-09 2013-11-19 Cyberonics, Inc. Medical lead termination sleeve for implantable medical devices
SG173069A1 (en) 2009-01-23 2011-08-29 Quadra Logic Tech Inc Sustained released delivery of one or more agents
US8786624B2 (en) 2009-06-02 2014-07-22 Cyberonics, Inc. Processing for multi-channel signals
DE102009030931A1 (de) 2009-06-24 2010-12-30 Eberhard-Karls-Universität Tübingen Universitätsklinikum Chirurgisches Wundverschlusselement
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US9643019B2 (en) 2010-02-12 2017-05-09 Cyberonics, Inc. Neurological monitoring and alerts
JP2013520239A (ja) * 2010-02-22 2013-06-06 マッツォッキ，ルディ，エイ 網膜を再構成するための最小限侵襲方法及び装置
US20110219325A1 (en) * 2010-03-02 2011-09-08 Himes David M Displaying and Manipulating Brain Function Data Including Enhanced Data Scrolling Functionality
EP2593141B1 (en) 2010-07-16 2018-07-04 Atrium Medical Corporation Composition and methods for altering the rate of hydrolysis of cured oil-based materials
TWI465243B (zh) 2011-06-21 2014-12-21 Bvw Holding Ag 含有乳香酸之治療劑成分
TW201311303A (zh) * 2011-06-21 2013-03-16 Bvw Holding Ag 植入定位裝置
US8776716B2 (en) 2011-08-09 2014-07-15 Biomet Biologics, Llc Surgical mesh spray and delivery system
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
CN103889401B (zh) 2011-08-29 2017-10-13 Qlt公司 持续释放递送活性剂以治疗青光眼和高眼压
US9474685B2 (en) 2011-09-28 2016-10-25 Sure-Shot Medical Device Inc. Apparatus for localized dermatological treatment
US8999376B2 (en) 2012-02-03 2015-04-07 Xcede Technologies, Inc. Tissue patch
US9440009B2 (en) 2012-02-16 2016-09-13 DePuy Synthes Products, Inc. Drug eluting insert for implantable body
JP6293727B2 (ja) * 2012-03-28 2018-03-14 エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ． 組織厚さコンペンセーター及びその製造方法
EP2844224B1 (en) 2012-05-03 2018-04-11 Mati Therapeutics Inc. Drug delivery system for treating open angle glaucoma and ocular hypertension
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
US9220807B2 (en) * 2012-11-04 2015-12-29 Miba Medical Inc. Non-toxic cross-linker for hyaluronic acid
CN105209084B (zh) 2013-03-13 2018-07-03 艾利丹尼森公司 改善的粘合性能
US11432990B2 (en) 2013-08-30 2022-09-06 ISOS Solutions, LLC Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same
US10022475B2 (en) * 2014-05-01 2018-07-17 Bao Tran Body augmentation device
WO2017027378A1 (en) 2015-08-07 2017-02-16 Xcede Technologies, Inc. Adhesive compositions and related methods
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
FR3041236B1 (fr) * 2015-09-21 2017-10-20 Vygon Systeme pour le traitement d'une epistaxis
US10932523B2 (en) 2015-11-30 2021-03-02 Nike, Inc. Electrorheological fluid structure with attached conductor and method of fabrication
CZ2016802A3 (cs) * 2016-12-16 2018-02-07 Synthesia, A. S. Supramolekulární komplex oxycelulózové matrice s antracyklinovým cytostatikem s postupným uvolňováním antracyklinového cytostatika a jeho použití
JP7362986B2 (ja) * 2017-08-28 2023-10-18 Ｓｂカワスミ株式会社 癒着防止材
EP3675670B1 (en) 2017-08-31 2021-07-28 NIKE Innovate C.V. Incline adjuster with multiple discrete chambers
WO2019157048A1 (en) * 2018-02-06 2019-08-15 The Trustees Of The University Of Pennsylvania The kirigami modification of biomedical tissue reinforcing meshes and matrices for expansile two-to-three dimensional conversion

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176664A (en) * 1978-03-13 1979-12-04 Stanley Kalish Impregnated bandage
US4747845A (en) * 1983-10-17 1988-05-31 Enquay Pharmaceutical Associates Synthetic resin matrix system for the extended delivery of drugs
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
WO1986002881A1 (en) * 1984-11-09 1986-05-22 Konishiroku Photo Industry Co., Ltd. Conductive laminate
US4865031A (en) * 1985-07-12 1989-09-12 Keeffe Paul J O Fabric and method of use for treatment of scars
US5250516A (en) * 1986-04-17 1993-10-05 Uab Research Foundation Bioelastomeric materials suitable for the protection of burn areas or the protection of wound repair sites from the occurrence of adhesions
US4895566A (en) 1986-07-25 1990-01-23 C. R. Bard, Inc. Coating medical devices with cationic antibiotics
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
US5134229A (en) * 1990-01-12 1992-07-28 Johnson & Johnson Medical, Inc. Process for preparing a neutralized oxidized cellulose product and its method of use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
IL102414A (en) 1991-07-25 1996-08-04 Univ Louisville Res Found Medicinal preparations for the treatment of ocular inflammation, containing rapamycin
US5708002A (en) 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
US5366504A (en) * 1992-05-20 1994-11-22 Boston Scientific Corporation Tubular medical prosthesis
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
US5516781A (en) * 1992-01-09 1996-05-14 American Home Products Corporation Method of treating restenosis with rapamycin
JPH08504763A (ja) * 1992-10-29 1996-05-21 セルトリックス ファーマシューティカルズ，インコーポレイテッド 治療薬としてのＴＧＦ−βレセプターフラグメントの使用
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5552162A (en) * 1993-02-09 1996-09-03 Arch Development Corporation Method for improvement of scar size and appearance
FR2707860B1 (fr) * 1993-07-23 1995-09-08 Bour Jean Appareil de mesure et de traitement de signaux physiologiques et procédé automatique mis en Óoeuvre par ledit appareil.
US5624893A (en) 1993-10-14 1997-04-29 Alcon Laboratories, Inc. Pharmaceutical compositions and methods of treatment of the cornea following laser irradiation
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
SG64372A1 (en) 1993-12-17 1999-04-27 Novartis Ag Rapamycin derivatives
US6063116A (en) * 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US5665591A (en) 1994-12-06 1997-09-09 Trustees Of Boston University Regulation of smooth muscle cell proliferation
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
US5496832A (en) 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
JPH11507697A (ja) 1995-06-09 1999-07-06 エヌ． ドロハン，ウィリアム キチンヒドロゲル、それらの製造方法及び利用
WO1996041807A1 (en) 1995-06-09 1996-12-27 Novartis Ag Rapamycin derivatives
US5798334A (en) * 1995-09-28 1998-08-25 Colla-Gene, Inc. Pharmaceutical compositions for scarless tissue repair and regeneration and methods related thereto
US5767135A (en) * 1995-12-29 1998-06-16 Fernandez-Pol; Jose Alberto Antiviral agent
WO1997031020A1 (en) 1996-02-22 1997-08-28 The General Hospital Corporation METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS
US5916585A (en) * 1996-06-03 1999-06-29 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto biodegradable polymers
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US5795286A (en) * 1996-08-15 1998-08-18 Cathco, Inc. Radioisotope impregnated sheet of biocompatible material for preventing scar tissue formation
EP1512398A1 (en) * 1997-03-31 2005-03-09 Boston Scientific Limited Intravascular stent with cytoskeletal inhibitors for the prevention of restenosis
ATE298740T1 (de) * 1997-04-04 2005-07-15 Mitsubishi Pharma Corp 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6015815A (en) 1997-09-26 2000-01-18 Abbott Laboratories Tetrazole-containing rapamycin analogs with shortened half-lives
US6273908B1 (en) * 1997-10-24 2001-08-14 Robert Ndondo-Lay Stents
US6015432A (en) * 1998-02-25 2000-01-18 Cordis Corporation Wire reinforced vascular prosthesis
US6063369A (en) * 1998-03-16 2000-05-16 Alterna, Inc. Quaternized hemp seed oil
AU761058B2 (en) * 1998-04-07 2003-05-29 Macropore, Inc. Membrane with tissue-guiding surface corrugations
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
US6312713B1 (en) * 1998-06-12 2001-11-06 Bernard Korol Polymer matrices for storage and sustained release of drugs and chemicals
US6060474A (en) * 1998-11-05 2000-05-09 New York Society For The Relief Of The Ruptured And Crippled Maintaining The Hospital For Special Surgery Method for preventing scar tissue formation
US6187024B1 (en) * 1998-11-10 2001-02-13 Target Therapeutics, Inc. Bioactive coating for vaso-occlusive devices
US6702828B2 (en) * 1999-09-01 2004-03-09 Converge Medical, Inc. Anastomosis system
CA2396628A1 (en) * 2000-01-25 2001-08-02 Edwards Lifesciences Corporation Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia
US6776796B2 (en) * 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US7419678B2 (en) * 2000-05-12 2008-09-02 Cordis Corporation Coated medical devices for the prevention and treatment of vascular disease
AU2002249958B2 (en) * 2001-01-16 2007-11-08 Vascular Therapies, Inc. Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts

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