BR0014961A - Pablo, um polipeptìdeo que interage com bcl-xl, e utilização relacionada ao mesmo - Google Patents

Pablo, um polipeptìdeo que interage com bcl-xl, e utilização relacionada ao mesmo

Info

Publication number
BR0014961A
BR0014961A BR0014961-6A BR0014961A BR0014961A BR 0014961 A BR0014961 A BR 0014961A BR 0014961 A BR0014961 A BR 0014961A BR 0014961 A BR0014961 A BR 0014961A
Authority
BR
Brazil
Prior art keywords
bcl
pablo
polypeptide
interacts
polypeptides
Prior art date
Application number
BR0014961-6A
Other languages
English (en)
Inventor
Robert Mark
Kathleen H Young
Andrew Wood
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0014961A publication Critical patent/BR0014961A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Plant Pathology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: "PABLO, UM POLIPEPTìDEO QUE INTERAGE COM BCL-XL, E UTILIZAçãO RELACIONADA AO MESMO". A presente invenção refere-se, pelo menos em parte, a polipeptídeos que incluem domínios ligando Bcl-xL, novo domínio ligando Bcl-xL de polipeptídeo Pablo, moléculas de ácido nucléico codificando tais polipeptídeos e utilizações dos mesmos. Por exemplo, tais polipeptídeos e moléculas de ácido nucléico são úteis na modulação de apoptose, particularmente em células neurais, assim como no tratamento ou prevenção de distúrbios que podem se beneficiar da modulação da morte celular.
BR0014961-6A 1999-10-22 2000-10-20 Pablo, um polipeptìdeo que interage com bcl-xl, e utilização relacionada ao mesmo BR0014961A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42550199A 1999-10-22 1999-10-22
PCT/US2000/029149 WO2001030845A1 (en) 1999-10-22 2000-10-20 Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto

Publications (1)

Publication Number Publication Date
BR0014961A true BR0014961A (pt) 2002-07-02

Family

ID=23686836

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0014961-6A BR0014961A (pt) 1999-10-22 2000-10-20 Pablo, um polipeptìdeo que interage com bcl-xl, e utilização relacionada ao mesmo

Country Status (10)

Country Link
US (2) US20020137049A1 (pt)
EP (1) EP1222206A1 (pt)
JP (1) JP2003515319A (pt)
KR (1) KR20020059639A (pt)
CN (1) CN1382156A (pt)
AU (1) AU1340001A (pt)
BR (1) BR0014961A (pt)
CA (1) CA2387680A1 (pt)
MX (1) MXPA02003664A (pt)
WO (1) WO2001030845A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040157327A1 (en) * 1999-10-22 2004-08-12 Wyeth Pablo, a polypeptide that interacts with BCL-XL, and uses related thereto
GB0200689D0 (en) * 2002-01-10 2002-02-27 Univ Newcastle Fusion proteins
US20030215852A1 (en) * 2002-04-01 2003-11-20 Wyeth Novel pancortin-Pablo protein interactions and methods of use thereof
JP2007532094A (ja) * 2003-05-16 2007-11-15 アコーダ セラピューティクス、インク． Ｃｎｓ治療用のプロテオグリカン分解変異体
CA2738983C (en) * 2008-10-10 2018-05-15 Dana Farber Cancer Institute Chemical modulators of pro-apoptotic bax and bcl-2 polypeptides
KR101492729B1 (ko) * 2013-08-28 2015-02-12 양기선 성기능 강화용 링
CN113637653B (zh) * 2021-08-05 2023-05-23 云南师范大学 一种活性提高的酯酶突变体Est8-XL及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3665893A (en) * 1992-02-12 1993-09-03 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The Sequences characteristic of human gene transcription product
US5656725A (en) 1995-05-12 1997-08-12 Apoptosis Technology, Inc. Peptides and compositions which modulate apoptosis

Also Published As

Publication number Publication date
JP2003515319A (ja) 2003-05-07
EP1222206A1 (en) 2002-07-17
US20030190709A1 (en) 2003-10-09
AU1340001A (en) 2001-05-08
US20020137049A1 (en) 2002-09-26
US6664068B2 (en) 2003-12-16
KR20020059639A (ko) 2002-07-13
WO2001030845A1 (en) 2001-05-03
MXPA02003664A (es) 2003-10-14
CA2387680A1 (en) 2001-05-03
CN1382156A (zh) 2002-11-27

Similar Documents

Publication Publication Date Title
DE59903921D1 (de) Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen
DE69333731D1 (de) Glialmitogene faktoren, ihre herstellung und verwendung
DE69435038D1 (de) Aktivin rezeptor-ähnliche kinase (alk), gehörend zur tgf rezeptorfamilie und/oder zur bmp rezeptorfamilie
DE69636365D1 (de) Peptide und zusammensetzungen, die die apoptose modulieren.
NZ323795A (en) Isolated nucleic acid molecules encoding AUR-1 (aurora-1) and AUR-2 polypeptides
DE69838483D1 (de) Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten
DE69435307D1 (de) Bazillus Thuringiensis und dessen insektizide Proteine
NO179412C (no) Hybrid DNA-molekyl som koder for fibronektinbindende protein, mikroorganismer inneholdende slike DNA-molekyler samt fremgangsmåte ved fremstilling av slikt protein
DE69942861D1 (de) Ldcam genannte moleküle
BR0014961A (pt) Pablo, um polipeptìdeo que interage com bcl-xl, e utilização relacionada ao mesmo
BR0316923A (pt) Polipeptìdeo mitoneet de membranas mitocondriais, seus moduladores e métodos para utilização do mesmo
ATE191922T1 (de) Feststellung der wechselwirkungsstelle zwischen p21-waf und pcna und deren therapeutischen verwendungen
BR9911349A (pt) Genes para a biossìntese de epotilonas
ATE350472T1 (de) Jmy, mit-aktivator für p300/cbp, dafür kodierendenucleinsäure und deren verwendungen
DE50000504D1 (de) Ionische flüssigkeiten, ihre herstellung und ihre verwendung
Johnson et al. Human acetylcholinesterase binds to mouse laminin-1 and human collagen IV by an electrostatic mechanism at the peripheral anionic site
DE69434315D1 (de) Dap-2 tumorsupressorgen, durch sie kodierte protein und verwendung besagter gen und protein
WO2000020446A3 (en) Bax-mediated apoptosis modulating reagents and methods
DE60214867D1 (en) Histonedeacetylase 9
ATE357516T1 (de) Modulation molekularer wechselwirkungspositionen in rns und anderen biomolekülen
WO2001016317A3 (en) Polycyclic aromatic hydrocarbon induced molecules
ATE397662T1 (de) Neues polypeptid, dafür kodierende dna und deren verwendungen
WO2002012887A3 (en) Methods and compositions for the diagnosis and treatment of brown adipose cell disorders
ATE121388T1 (de) 3- oder 4-substituierte oxotremorin-derivate.
ATE395935T1 (de) An der oberfläche von karzinomzellen lokalisiertes colligin/hsp47

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A,7A E 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008.