BR0009701A - Compostos ou sais, ou suas composições, uso dos mesmos, e, formulações farmacêuticas - Google Patents
Compostos ou sais, ou suas composições, uso dos mesmos, e, formulações farmacêuticasInfo
- Publication number
- BR0009701A BR0009701A BR0009701-2A BR0009701A BR0009701A BR 0009701 A BR0009701 A BR 0009701A BR 0009701 A BR0009701 A BR 0009701A BR 0009701 A BR0009701 A BR 0009701A
- Authority
- BR
- Brazil
- Prior art keywords
- salts
- compounds
- pharmaceutical formulations
- compositions
- precursor
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- -1 use thereof Substances 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
"COMPOSTOS OU SAIS, OU SUAS COMPOSIçõES USO DOS MESMOS, E, FORMULAçõES FARMACêUTICAS". Compostos ou seus sais de fórmula geral (I): A-(B) em que A R-T~ 1~-, em que R é o radical do medicamento e T~ 1~= (CO), ou (X)~ t'~, em que X = O, S, NR~ 1c~, R~ 1c~ é H ou uma alquila tendo de 1 a 5 átomos de carbono, ou uma valência livre, t e t' são números inteiros e iguais a zero ou 1, com a condição de que t = 1 quando t' = 0; t:= 0 quando t' = 1; B = -T~ B~-X~ 2~ em que TB= (CO) quando t = 0, TB= X quando t' = -, X sendo como definido acima; X~ 2~, radical monovalente, é tal que o medicamento precursor de A e o precursor de B respectivamente enfrentam os testes farmacológicos descritos no pedido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000750A IT1311921B1 (it) | 1999-04-13 | 1999-04-13 | Composti farmaceutici. |
PCT/EP2000/003237 WO2000061549A2 (en) | 1999-04-13 | 2000-04-11 | Pharmaceutical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0009701A true BR0009701A (pt) | 2002-04-02 |
Family
ID=11382682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009701-2A BR0009701A (pt) | 1999-04-13 | 2000-04-11 | Compostos ou sais, ou suas composições, uso dos mesmos, e, formulações farmacêuticas |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP1192129A2 (pt) |
JP (1) | JP2002541242A (pt) |
KR (1) | KR20020005671A (pt) |
CN (1) | CN1356981A (pt) |
AU (1) | AU3820000A (pt) |
BR (1) | BR0009701A (pt) |
CA (1) | CA2370406A1 (pt) |
HU (1) | HUP0200747A3 (pt) |
IL (1) | IL145632A0 (pt) |
IT (1) | IT1311921B1 (pt) |
MX (1) | MXPA01010209A (pt) |
NO (1) | NO20014926L (pt) |
PL (1) | PL351241A1 (pt) |
TR (1) | TR200102939T2 (pt) |
WO (1) | WO2000061549A2 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
WO2001045703A1 (en) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
JP2004501143A (ja) | 2000-06-22 | 2004-01-15 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化タキサン、組成物および使用方法 |
CA2432642A1 (en) | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
WO2002087508A2 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
WO2003103602A2 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
AU2003247792B2 (en) | 2002-07-03 | 2009-09-24 | Nicox S.A. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
US7244753B2 (en) | 2002-07-29 | 2007-07-17 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
ZA200707021B (en) * | 2002-11-22 | 2008-06-25 | Univ Johns Hopkins | Use in therapy of a small molecule |
CA2554716A1 (en) * | 2004-01-22 | 2005-08-04 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
KR100678287B1 (ko) * | 2005-06-23 | 2007-02-02 | 한미약품 주식회사 | 클로피도그렐의 제조방법 및 이에 사용되는 중간체 |
CN100404543C (zh) * | 2006-09-21 | 2008-07-23 | 浙江海正药业股份有限公司 | 一种合成吡利霉素的中间体及其制备方法和用途 |
CA2758698C (en) * | 2009-04-17 | 2017-08-08 | Vidasym, Llc | Vitamin d receptor agonists and uses thereof |
US9598383B2 (en) * | 2013-06-26 | 2017-03-21 | The Regents Of The University Of California | Reactive oxygen species-based prodrugs |
CN107418989A (zh) * | 2017-08-21 | 2017-12-01 | 浙江工业大学 | 一种脂肪酶催化在线合成n‑(5‑蔗糖酯戊酰基)美托洛尔的方法 |
CN113209065B (zh) * | 2021-03-29 | 2023-06-20 | 中国科学院西北高原生物研究所 | 生物碱化合物在制备预防和/或治疗心脏损伤的产品中的用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1134458B (it) * | 1980-11-26 | 1986-08-13 | Real Sas Di Alberto Reiner | Derivato della n-acetil-cisteina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche |
IT1190987B (it) * | 1982-09-07 | 1988-02-24 | Pharma Edmond Srl | Tioesteri dell'acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono |
ES8609231A1 (es) * | 1985-12-03 | 1986-09-01 | Farmhispania | Procedimiento de obtencion del n-acetil-3(2-(acetiloxi)ben- zoilmercapto)alanina |
IT1213301B (it) * | 1986-07-14 | 1989-12-20 | Zambon Spa | Composizioni per il trattamento del le sindromi da ischemia e riperfusione |
AU2387997A (en) * | 1997-04-18 | 1998-11-13 | Klinge Pharma Gmbh | Stabilized medicaments containing cysteinyl derivatives |
-
1999
- 1999-04-13 IT IT1999MI000750A patent/IT1311921B1/it active
-
2000
- 2000-04-11 AU AU38200/00A patent/AU3820000A/en not_active Abandoned
- 2000-04-11 TR TR2001/02939T patent/TR200102939T2/xx unknown
- 2000-04-11 HU HU0200747A patent/HUP0200747A3/hu unknown
- 2000-04-11 BR BR0009701-2A patent/BR0009701A/pt not_active IP Right Cessation
- 2000-04-11 IL IL14563200A patent/IL145632A0/xx unknown
- 2000-04-11 CN CN00808855A patent/CN1356981A/zh active Pending
- 2000-04-11 PL PL00351241A patent/PL351241A1/xx not_active Application Discontinuation
- 2000-04-11 EP EP00917074A patent/EP1192129A2/en not_active Withdrawn
- 2000-04-11 JP JP2000610825A patent/JP2002541242A/ja active Pending
- 2000-04-11 CA CA002370406A patent/CA2370406A1/en not_active Abandoned
- 2000-04-11 MX MXPA01010209A patent/MXPA01010209A/es unknown
- 2000-04-11 KR KR1020017012971A patent/KR20020005671A/ko not_active Application Discontinuation
- 2000-04-11 WO PCT/EP2000/003237 patent/WO2000061549A2/en not_active Application Discontinuation
-
2001
- 2001-10-10 NO NO20014926A patent/NO20014926L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2000061549A3 (en) | 2002-01-03 |
IL145632A0 (en) | 2002-06-30 |
NO20014926D0 (no) | 2001-10-10 |
KR20020005671A (ko) | 2002-01-17 |
HUP0200747A2 (en) | 2002-06-29 |
EP1192129A2 (en) | 2002-04-03 |
NO20014926L (no) | 2001-12-13 |
CA2370406A1 (en) | 2000-10-19 |
HUP0200747A3 (en) | 2003-02-28 |
CN1356981A (zh) | 2002-07-03 |
ITMI990750A1 (it) | 2000-10-13 |
PL351241A1 (en) | 2003-04-07 |
IT1311921B1 (it) | 2002-03-20 |
TR200102939T2 (tr) | 2002-09-23 |
AU3820000A (en) | 2000-11-14 |
MXPA01010209A (es) | 2003-07-21 |
JP2002541242A (ja) | 2002-12-03 |
WO2000061549A2 (en) | 2000-10-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A, E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1929 DE 26/12/2007. |