BR0002607A - Composições lìquidas rapidamente absorvidas - Google Patents

Composições lìquidas rapidamente absorvidas

Info

Publication number
BR0002607A
BR0002607A BR0002607-7A BR0002607A BR0002607A BR 0002607 A BR0002607 A BR 0002607A BR 0002607 A BR0002607 A BR 0002607A BR 0002607 A BR0002607 A BR 0002607A
Authority
BR
Brazil
Prior art keywords
liquid compositions
quickly absorbed
absorbed liquid
pharmaceutically acceptable
features
Prior art date
Application number
BR0002607-7A
Other languages
English (en)
Inventor
Cathy Clech Gelotte
Joanna F Hills
Charles E Ii Pendley
Manoj N Shah
Original Assignee
Johnson & Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson filed Critical Johnson & Johnson
Publication of BR0002607A publication Critical patent/BR0002607A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"COMPOSIçõES LìQUIDAS RAPIDAMENTE ABSORVIDAS''<D>. A presente invenção apresenta um método que propociona uma absorção mais rápida de aminas farmaceuticamente aceitáveis. O método apresenta uma amina farmaceuticamente aceitável em combinação com um medicamento antiinflamatório não-esteróide em uma forma líquida. Uma modalidade preferida emprega pseudoefedrina e ibuprofeno.
BR0002607-7A 1999-06-10 2000-06-09 Composições lìquidas rapidamente absorvidas BR0002607A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/329,900 US6211246B1 (en) 1999-06-10 1999-06-10 Rapidly absorbed liquid compositions

Publications (1)

Publication Number Publication Date
BR0002607A true BR0002607A (pt) 2001-01-02

Family

ID=23287505

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0002607-7A BR0002607A (pt) 1999-06-10 2000-06-09 Composições lìquidas rapidamente absorvidas

Country Status (14)

Country Link
US (6) US6211246B1 (pt)
EP (1) EP1059084B1 (pt)
JP (1) JP2001019638A (pt)
KR (1) KR20010007332A (pt)
CN (1) CN1151784C (pt)
AR (1) AR024314A1 (pt)
AU (1) AU3794300A (pt)
BR (1) BR0002607A (pt)
CA (1) CA2311039A1 (pt)
CO (1) CO5160329A1 (pt)
ES (1) ES2397262T3 (pt)
NZ (1) NZ504944A (pt)
SA (1) SA00210280B1 (pt)
ZA (1) ZA200002892B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
KR100425900B1 (ko) * 2001-05-04 2004-04-03 대원제약주식회사 고농도 투명액상 이부프로펜 용액을 함유하는 속효성연질캅셀제
JP2009132734A (ja) * 2001-08-27 2009-06-18 Daiichi Sankyo Healthcare Co Ltd 抗感冒剤
JP4318899B2 (ja) * 2001-08-27 2009-08-26 第一三共ヘルスケア株式会社 抗感冒剤
US7049435B2 (en) 2002-03-08 2006-05-23 Tate & Lyle Public Limited Company Extractive methods for purifying sucralose
US6998480B2 (en) 2002-03-08 2006-02-14 Tate & Lyle Public Limited Company Process for improving sucralose purity and yield
US20050266031A1 (en) * 2004-05-25 2005-12-01 Jay Dickerson Pharmaceutical suspension composition
AU2005260024B2 (en) * 2004-06-30 2009-03-26 E-L Management Corp. Cosmetic compositions and methods comprising Rhodiola rosea
US20060062811A1 (en) * 2004-09-21 2006-03-23 Szymczak Christopher E Medicinal cooling emulsions
JP2010510320A (ja) 2006-11-21 2010-04-02 マクニール−ピーピーシー・インコーポレーテツド 改変型放出鎮痛性懸濁液
JP5360751B2 (ja) * 2007-01-29 2013-12-04 株式会社 メドレックス 非ステロイド系抗炎症薬と有機アミン化合物との塩とその用途
US9833510B2 (en) * 2007-06-12 2017-12-05 Johnson & Johnson Consumer Inc. Modified release solid or semi-solid dosage forms
AR070082A1 (es) * 2008-01-04 2010-03-10 Tate & Lyle Technology Ltd Metodo para la produccion de sucralosa
JP2011517445A (ja) * 2008-03-20 2011-06-09 テート アンド ライル テクノロジー リミテッド 第三級アミド溶媒からの酸の除去
US8436157B2 (en) 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
WO2009124113A1 (en) * 2008-04-03 2009-10-08 Tate & Lyle Technology Ltd. Extraction of less polar impurities from sucralose containing aqueous feed streams
KR20100127875A (ko) * 2008-04-03 2010-12-06 테이트 앤드 라일 테크놀러지 리미티드 수크랄로오스 추출 효율에 대한 탄수화물 농도의 효과
AR071134A1 (es) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd Cristalizacion de sucralosa a partir de chorros que contienen sucralosa
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
CA2757337A1 (en) 2009-04-03 2010-10-07 Coating Place, Inc. Modified-release pharmaceutical drug composition
GB2474311B (en) 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB2474310B (en) 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
US9498433B1 (en) * 2013-09-30 2016-11-22 Make Ideas, LLC Edible animal medicine container
US10821073B1 (en) 2013-09-30 2020-11-03 Make Ideas, LLC Edible animal medicine container
US11503806B1 (en) 2018-06-12 2022-11-22 Make Ideas Llc Dog dental device with brushes extending through compressible outer shell
GB2585825B (en) * 2019-07-09 2023-03-22 Lexon Uk Holdings Ltd Suspending vehicle formulation
EP4081187B1 (en) * 2019-12-23 2023-12-13 Nutra Essential OTC, S.L. Liquid composition comprising ibuprofen and phenylephrine

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486436A (en) 1982-07-22 1984-12-04 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4656177A (en) 1982-07-22 1987-04-07 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
US4587249A (en) 1982-07-22 1986-05-06 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
DE3236370A1 (de) 1982-10-01 1984-04-05 Varta Batterie Ag, 3000 Hannover Gas- und fluessigkeitsdichte polabdichtung fuer elektrische akkumulatoren, insbesondere bleiakkumulatoren
US4567183A (en) 1983-03-11 1986-01-28 Analgesic Associates Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4479956A (en) 1983-04-26 1984-10-30 Analgeic Associates Analgesic compositions comprising propiram and methods of using same
US4558051A (en) 1983-10-11 1985-12-10 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
US4985459A (en) 1984-02-08 1991-01-15 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4522826A (en) 1984-02-08 1985-06-11 Richardson-Vicks Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4585783A (en) 1984-02-08 1986-04-29 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
US4552899A (en) 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4871733A (en) 1984-04-09 1989-10-03 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4783465A (en) 1984-04-09 1988-11-08 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US5025019A (en) 1984-04-09 1991-06-18 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
US4923898A (en) 1984-12-26 1990-05-08 Analgesic Associates Analgesic, anti-inflammatory and skeletal muscle relaxant compositions comprising non-steroidal anti-inflammatory drugs and musculoskeletal relaxants and methods of using same
US4975426A (en) 1987-06-08 1990-12-04 Analgesic Associates Cough/cold mixtures comprising non-sedating antihistamine drugs
US4980375A (en) 1987-07-10 1990-12-25 Sterling Drug Inc. Onset-hastened/enhanced antipyretic response
US4883818A (en) 1987-11-17 1989-11-28 Analgesic Associates Onset-hastened/enhanced analgesia
US4962124A (en) 1987-11-17 1990-10-09 Analgesic Associates Onset-hastened/enhanced antipyretic response
US5286751A (en) 1987-12-24 1994-02-15 Analgesic Associates Sustained/enhanced antipyretic response
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5100918A (en) 1989-05-25 1992-03-31 Sterling Drug, Inc. Prevention or treatment of sunburn using the S(+) isomer of ibuprofen
NZ234143A (en) 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
NZ234587A (en) 1989-08-04 1991-11-26 Mcneil Ppc Inc A chewable pharmaceutical tablet of compressed coated granules
US5198227A (en) 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
US5075114A (en) 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
WO1992015332A1 (en) 1991-03-04 1992-09-17 Warner-Lambert Company Novel salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
JPH06506684A (ja) * 1991-04-01 1994-07-28 メルク　エンド　カンパニー　インコーポレーテッド イブプロフェン−充血除去剤配合物
GB9207990D0 (en) 1992-04-10 1992-05-27 Smithkline Beecham Plc Pharmaceutical composition
US5981591A (en) 1992-12-04 1999-11-09 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
WO1994014449A1 (en) * 1992-12-21 1994-07-07 The Procter & Gamble Company Compositions containing caffeine and s(+)-ibuprofen or s(+)-flurbiprofen or s(+)-ketoprofen
CA2151912A1 (en) * 1992-12-21 1994-07-07 Richard Wilfred D'souza Use of s(+) antipodes of analgesic agents for the manufacture of a composition to treat respiratory disorders
US5834479A (en) 1993-03-05 1998-11-10 Mayer; David J. Method and composition for alleviating pain
IT1264857B1 (it) 1993-06-21 1996-10-17 Zambon Spa Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico
BR9407414A (pt) * 1993-09-07 1996-11-12 Procter & Gamble Composições contendo um sal de aminoácido de agente antiinflamatório não-esteroide de ácido propiônico e pelo menos um descongestionante um expectorante um anti-histamina e um antitussivo
JPH09502202A (ja) * 1993-09-07 1997-03-04 ザ、プロクター、エンド、ギャンブル、カンパニー プロピオン酸非ステロイド系抗炎症剤のアミノ酸塩とカフェインを含有した組成物
US5674522A (en) 1993-10-07 1997-10-07 Mcneil-Ppc, Inc. Beverage concentrate for drug delivery
CZ210496A3 (en) * 1994-01-24 1996-12-11 Procter & Gamble Method improving solution process of difficult-to dissolve pharmaceutically active compounds
US5576311A (en) 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
US5582838A (en) 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US5718919A (en) 1995-02-24 1998-02-17 Nanosystems L.L.C. Nanoparticles containing the R(-)enantiomer of ibuprofen
US5641512A (en) 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
JP3170619B2 (ja) * 1995-04-20 2001-05-28 参天製薬株式会社 有機アミンを配合したプラノプロフェン点眼液
JP3382076B2 (ja) * 1995-12-12 2003-03-04 佐藤製薬株式会社 イブプロフェンを溶解してなるかぜ薬軟カプセル及びその製造方法
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US6231890B1 (en) 1996-05-02 2001-05-15 Taisho Pharmaceutical Co., Ltd. Suspension of sparingly water-soluble acidic drug
JPH1045595A (ja) * 1996-05-22 1998-02-17 Taisho Pharmaceut Co Ltd 鎮咳剤
JPH1045591A (ja) * 1996-05-22 1998-02-17 Taisho Pharmaceut Co Ltd 鎮咳剤
US5712310A (en) * 1996-06-14 1998-01-27 Alpharma Uspd, Inc. Suspension of substantially water-insoluble drugs and methods of their manufacture
US5759579A (en) * 1996-12-05 1998-06-02 American Home Products Corporation Pharmaceutical suspension systems
IN186315B (pt) * 1996-12-12 2001-08-04 Panacea Biotec Ltd
US6274592B1 (en) * 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
GB9704524D0 (en) 1997-03-05 1997-04-23 Smithkline Beecham Plc Composition
US5840768A (en) 1997-06-04 1998-11-24 Fmc Corporation MCC: alginate pharmaceutical suspensions
US6132758A (en) 1998-06-01 2000-10-17 Schering Corporation Stabilized antihistamine syrup
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions

Also Published As

Publication number Publication date
CO5160329A1 (es) 2002-05-30
US20030083379A1 (en) 2003-05-01
US20060128809A1 (en) 2006-06-15
AU3794300A (en) 2000-12-14
US7060730B2 (en) 2006-06-13
CN1277841A (zh) 2000-12-27
CA2311039A1 (en) 2000-12-10
ZA200002892B (en) 2001-12-10
ES2397262T3 (es) 2013-03-05
US20040091508A1 (en) 2004-05-13
EP1059084B1 (en) 2012-11-07
AR024314A1 (es) 2002-09-25
US6211246B1 (en) 2001-04-03
JP2001019638A (ja) 2001-01-23
EP1059084A2 (en) 2000-12-13
US20010005729A1 (en) 2001-06-28
NZ504944A (en) 2002-03-28
SA00210280B1 (ar) 2005-12-26
CN1151784C (zh) 2004-06-02
US20040091507A1 (en) 2004-05-13
EP1059084A3 (en) 2002-11-06
KR20010007332A (ko) 2001-01-26

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: A61K 31/37, A61K 31/192, A61P 11/02, A61P 29/00

Ipc: A61K 9/08 (2009.01), A61K 31/137 (2009.01), A61K 3

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 13 E 25 DA LPI.

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.