BG62487B1 - Изопропил-(2-метоксиетил)-4-(2-хлоро-3-цианофенил)-1,4- дихидро-2,6-диметилпиридин-3,5-дикарбоксилат, метод за неговото получаване и приложение в лекарствени средства, които го съдържат, междинни съединения за неговото получаване - Google Patents

Изопропил-(2-метоксиетил)-4-(2-хлоро-3-цианофенил)-1,4- дихидро-2,6-диметилпиридин-3,5-дикарбоксилат, метод за неговото получаване и приложение в лекарствени средства, които го съдържат, междинни съединения за неговото получаване Download PDF

Info

Publication number
BG62487B1
BG62487B1 BG99249A BG9924994A BG62487B1 BG 62487 B1 BG62487 B1 BG 62487B1 BG 99249 A BG99249 A BG 99249A BG 9924994 A BG9924994 A BG 9924994A BG 62487 B1 BG62487 B1 BG 62487B1
Authority
BG
Bulgaria
Prior art keywords
formula
chloro
preparation
compound
optionally
Prior art date
Application number
BG99249A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99249A (en
Inventor
Heinrich Meier
Wolfgang Hartwig
Bodo Junge
Rudolf Schohe-Loop
Zhan Gao
Bernard Schmidt
Jonge Maarten De
Teunis Schuurman
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4342194A external-priority patent/DE4342194A1/de
Priority claimed from DE19944424677 external-priority patent/DE4424677A1/de
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG99249A publication Critical patent/BG99249A/bg
Publication of BG62487B1 publication Critical patent/BG62487B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Liquid Crystal Substances (AREA)
BG99249A 1993-12-10 1994-12-08 Изопропил-(2-метоксиетил)-4-(2-хлоро-3-цианофенил)-1,4- дихидро-2,6-диметилпиридин-3,5-дикарбоксилат, метод за неговото получаване и приложение в лекарствени средства, които го съдържат, междинни съединения за неговото получаване BG62487B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4342194A DE4342194A1 (de) 1993-12-10 1993-12-10 Halogen-phenyl-substituierte 1,4-Dihydropyridine
DE19944424677 DE4424677A1 (de) 1994-07-13 1994-07-13 Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Publications (2)

Publication Number Publication Date
BG99249A BG99249A (en) 1995-09-29
BG62487B1 true BG62487B1 (bg) 1999-12-30

Family

ID=25931956

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99249A BG62487B1 (bg) 1993-12-10 1994-12-08 Изопропил-(2-метоксиетил)-4-(2-хлоро-3-цианофенил)-1,4- дихидро-2,6-диметилпиридин-3,5-дикарбоксилат, метод за неговото получаване и приложение в лекарствени средства, които го съдържат, междинни съединения за неговото получаване

Country Status (35)

Country Link
US (1) US5665740A (fi)
EP (1) EP0657430B1 (fi)
JP (1) JP3751041B2 (fi)
KR (1) KR100332325B1 (fi)
CN (2) CN1056606C (fi)
AT (1) ATE180774T1 (fi)
AU (1) AU686976B2 (fi)
BG (1) BG62487B1 (fi)
CA (1) CA2137525C (fi)
CO (1) CO4290426A1 (fi)
CU (1) CU22713A3 (fi)
CZ (1) CZ286065B6 (fi)
DE (1) DE59408350D1 (fi)
DK (1) DK0657430T3 (fi)
DZ (1) DZ1831A1 (fi)
EE (1) EE03192B1 (fi)
ES (1) ES2132308T3 (fi)
FI (1) FI105681B (fi)
GR (1) GR3030436T3 (fi)
HR (1) HRP940967B1 (fi)
HU (1) HU215593B (fi)
IL (1) IL111922A (fi)
LV (1) LV11321B (fi)
MA (1) MA23392A1 (fi)
MY (1) MY111976A (fi)
NO (1) NO302362B1 (fi)
NZ (1) NZ270087A (fi)
PL (1) PL179973B1 (fi)
RO (1) RO115800B1 (fi)
SA (1) SA95160078B1 (fi)
SK (1) SK282399B6 (fi)
SV (1) SV1994000072A (fi)
TN (1) TNSN94127A1 (fi)
TW (1) TW412529B (fi)
YU (1) YU48920B (fi)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005051389A1 (en) * 2003-11-21 2005-06-09 Memory Pharmaceuticals Corporation Using of (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dymethyl-pyridine-3,5-dicarboxylate in the treatment of memory disorders
WO2008058234A2 (en) * 2006-11-08 2008-05-15 Memory Pharmaceuticals Corporation Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility
US11512052B2 (en) * 2017-11-21 2022-11-29 Icahn School Of Medicine At Mount Sinai Dihydropyridines for the treatment of cognitive impairment or traumatic brain injury

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
DE3718398A1 (de) * 1987-06-02 1988-12-22 Troponwerke Gmbh & Co Kg Neue kombinationspraeparate mit antidepressiver wirkung
US5114946A (en) * 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
DE3806277A1 (de) * 1988-02-27 1989-09-07 Troponwerke Gmbh & Co Kg Verwendung von 1,4-dihydropyridin-derivaten
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester

Also Published As

Publication number Publication date
MA23392A1 (fr) 1995-07-01
SK151694A3 (en) 1995-07-11
MY111976A (en) 2001-03-31
EP0657430B1 (de) 1999-06-02
RO115800B1 (ro) 2000-06-30
DZ1831A1 (fr) 2002-02-17
NO944787D0 (no) 1994-12-09
SA95160078B1 (ar) 2006-09-25
IL111922A0 (en) 1995-03-15
HRP940967B1 (en) 1999-12-31
CZ309394A3 (en) 1995-11-15
CU22713A3 (es) 1996-07-05
FI945777A0 (fi) 1994-12-08
IL111922A (en) 1999-05-09
CA2137525A1 (en) 1995-06-11
LV11321B (en) 1996-12-20
ES2132308T3 (es) 1999-08-16
DK0657430T3 (da) 1999-11-15
FI105681B (fi) 2000-09-29
FI945777A (fi) 1995-06-11
AU8030694A (en) 1995-06-15
HUT70937A (en) 1995-11-28
CN1244525A (zh) 2000-02-16
JPH07242632A (ja) 1995-09-19
EE03192B1 (et) 1999-06-15
YU71794A (sh) 1996-10-18
TW412529B (en) 2000-11-21
CZ286065B6 (cs) 2000-01-12
JP3751041B2 (ja) 2006-03-01
SV1994000072A (es) 1995-08-09
SK282399B6 (sk) 2002-01-07
KR950017958A (ko) 1995-07-22
NO944787L (no) 1995-06-12
KR100332325B1 (ko) 2002-09-04
PL306157A1 (en) 1995-06-12
DE59408350D1 (de) 1999-07-08
LV11321A (lv) 1996-06-20
NO302362B1 (no) 1998-02-23
EP0657430A1 (de) 1995-06-14
YU48920B (sh) 2002-11-15
ATE180774T1 (de) 1999-06-15
CN1124258C (zh) 2003-10-15
BG99249A (en) 1995-09-29
GR3030436T3 (en) 1999-09-30
HRP940967A2 (en) 1997-08-31
PL179973B1 (pl) 2000-11-30
CN1056606C (zh) 2000-09-20
HU9403551D0 (en) 1995-02-28
HU215593B (hu) 1999-01-28
AU686976B2 (en) 1998-02-12
CA2137525C (en) 2005-07-12
US5665740A (en) 1997-09-09
CN1109874A (zh) 1995-10-11
CO4290426A1 (es) 1996-04-17
NZ270087A (en) 1996-08-27
TNSN94127A1 (en) 1995-09-21

Similar Documents

Publication Publication Date Title
BG62487B1 (bg) Изопропил-(2-метоксиетил)-4-(2-хлоро-3-цианофенил)-1,4- дихидро-2,6-диметилпиридин-3,5-дикарбоксилат, метод за неговото получаване и приложение в лекарствени средства, които го съдържат, междинни съединения за неговото получаване
SK158195A3 (en) Application of 5-acyl-1,4-dihydropyridines, 5-acyl- -1,4-dihydropyridines, manufacturing process thereof and pharmaceutical compositions containing them
SK104495A3 (en) 2,3-cyclicly condensed 1,4-dihydropyridines, process for preparing the same, drugs containing the same and their use
JP2007091750A (ja) フエニル−置換１，４−ジヒドロピリジン類の製造法
AU710863B2 (en) 2-chloro-3-cyano-benzaldehyde
CZ332895A3 (en) Use of 1,2-bridged 1,4-dihydropyridines, 1,2-bridged 1,4-dihydropyridines, process of their preparation and pharmaceutical compositions containing thereof
CZ239496A3 (en) Substituted 4h-pyrans, process of their preparation, their use and pharmaceutical composition containing thereof
US4252956A (en) Derivatives of 1,4-dihydropyridine-3-carbothiol acids
CZ286192A3 (en) Dihydropyridines substituted by indolesulfonamides, process of their preparation and their use in medicaments
CZ227693A3 (en) 4-heterocyclyl substituted dihydropyridines, process of their preparation and medicaments in which they are comprised
US6001857A (en) Heterocyclyl substituted dihydropyridines
SK104595A3 (en) Cyclohexadiene derivatives, method of their production, their use and medicaments containing these matters
JPH07196615A (ja) アリール−置換されたアルコキシカルボニル−１，４−ジヒドロピリジン−５−カルボン酸エステル類
DE4424677A1 (de) Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat
EP0657433A1 (de) Dihydropyridine mit substituierten Estern mit cerebraler Wirkung