NO302362B1 - Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat, legemidler inneholdende forbindelsen samt dens anvendelse, og mellomprodukt for fremstilling derav - Google Patents

Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat, legemidler inneholdende forbindelsen samt dens anvendelse, og mellomprodukt for fremstilling derav

Info

Publication number
NO302362B1
NO302362B1 NO944787A NO944787A NO302362B1 NO 302362 B1 NO302362 B1 NO 302362B1 NO 944787 A NO944787 A NO 944787A NO 944787 A NO944787 A NO 944787A NO 302362 B1 NO302362 B1 NO 302362B1
Authority
NO
Norway
Prior art keywords
preparation
dimethylpyridine
cyanophenyl
methoxyethyl
dihydro
Prior art date
Application number
NO944787A
Other languages
English (en)
Other versions
NO944787D0 (no
NO944787L (no
Inventor
Heinrich Meier
Wolfgang Hartwig
Bodo Junge
Rudolf Schohe-Loop
Zhan Gao
Bernard Schmidt
Maarten De Jonge
Teunis Schuurman
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4342194A external-priority patent/DE4342194A1/de
Priority claimed from DE19944424677 external-priority patent/DE4424677A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO944787D0 publication Critical patent/NO944787D0/no
Publication of NO944787L publication Critical patent/NO944787L/no
Publication of NO302362B1 publication Critical patent/NO302362B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
NO944787A 1993-12-10 1994-12-09 Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat, legemidler inneholdende forbindelsen samt dens anvendelse, og mellomprodukt for fremstilling derav NO302362B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4342194A DE4342194A1 (de) 1993-12-10 1993-12-10 Halogen-phenyl-substituierte 1,4-Dihydropyridine
DE19944424677 DE4424677A1 (de) 1994-07-13 1994-07-13 Isopropyl-(2-methoxyethyl)-4-(2-chlor-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarboxylat

Publications (3)

Publication Number Publication Date
NO944787D0 NO944787D0 (no) 1994-12-09
NO944787L NO944787L (no) 1995-06-12
NO302362B1 true NO302362B1 (no) 1998-02-23

Family

ID=25931956

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944787A NO302362B1 (no) 1993-12-10 1994-12-09 Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat, legemidler inneholdende forbindelsen samt dens anvendelse, og mellomprodukt for fremstilling derav

Country Status (35)

Country Link
US (1) US5665740A (no)
EP (1) EP0657430B1 (no)
JP (1) JP3751041B2 (no)
KR (1) KR100332325B1 (no)
CN (2) CN1056606C (no)
AT (1) ATE180774T1 (no)
AU (1) AU686976B2 (no)
BG (1) BG62487B1 (no)
CA (1) CA2137525C (no)
CO (1) CO4290426A1 (no)
CU (1) CU22713A3 (no)
CZ (1) CZ286065B6 (no)
DE (1) DE59408350D1 (no)
DK (1) DK0657430T3 (no)
DZ (1) DZ1831A1 (no)
EE (1) EE03192B1 (no)
ES (1) ES2132308T3 (no)
FI (1) FI105681B (no)
GR (1) GR3030436T3 (no)
HR (1) HRP940967B1 (no)
HU (1) HU215593B (no)
IL (1) IL111922A (no)
LV (1) LV11321B (no)
MA (1) MA23392A1 (no)
MY (1) MY111976A (no)
NO (1) NO302362B1 (no)
NZ (1) NZ270087A (no)
PL (1) PL179973B1 (no)
RO (1) RO115800B1 (no)
SA (1) SA95160078B1 (no)
SK (1) SK282399B6 (no)
SV (1) SV1994000072A (no)
TN (1) TNSN94127A1 (no)
TW (1) TW412529B (no)
YU (1) YU48920B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1684806B1 (en) * 2003-11-21 2008-06-25 Memory Pharmaceuticals Corporation Compositions comprising l-type calcium channel blockers and cholinesterase inhibitors
WO2008058234A2 (en) * 2006-11-08 2008-05-15 Memory Pharmaceuticals Corporation Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility
US11512052B2 (en) * 2017-11-21 2022-11-29 Icahn School Of Medicine At Mount Sinai Dihydropyridines for the treatment of cognitive impairment or traumatic brain injury

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963188A1 (de) * 1969-12-17 1971-06-24 Bayer Ag Neue Cyanphenyl-1,4-dihydropyridinderivate
DE2117572C3 (de) * 1971-04-10 1980-03-20 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3239273A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
DE3718398A1 (de) * 1987-06-02 1988-12-22 Troponwerke Gmbh & Co Kg Neue kombinationspraeparate mit antidepressiver wirkung
US5114946A (en) * 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
DE3806277A1 (de) * 1988-02-27 1989-09-07 Troponwerke Gmbh & Co Kg Verwendung von 1,4-dihydropyridin-derivaten
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung
FR2671349B1 (fr) * 1991-01-09 1993-04-23 Lafon Labor Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE4125271A1 (de) * 1991-07-31 1993-02-11 Bayer Ag Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester

Also Published As

Publication number Publication date
SK151694A3 (en) 1995-07-11
MY111976A (en) 2001-03-31
KR950017958A (ko) 1995-07-22
EP0657430B1 (de) 1999-06-02
SA95160078B1 (ar) 2006-09-25
YU71794A (sh) 1996-10-18
FI945777A (fi) 1995-06-11
CN1056606C (zh) 2000-09-20
ES2132308T3 (es) 1999-08-16
BG99249A (en) 1995-09-29
CN1109874A (zh) 1995-10-11
TW412529B (en) 2000-11-21
KR100332325B1 (ko) 2002-09-04
NZ270087A (en) 1996-08-27
HUT70937A (en) 1995-11-28
SK282399B6 (sk) 2002-01-07
US5665740A (en) 1997-09-09
IL111922A (en) 1999-05-09
CU22713A3 (es) 1996-07-05
NO944787D0 (no) 1994-12-09
FI945777A0 (fi) 1994-12-08
PL179973B1 (pl) 2000-11-30
LV11321B (en) 1996-12-20
DK0657430T3 (da) 1999-11-15
CA2137525C (en) 2005-07-12
NO944787L (no) 1995-06-12
TNSN94127A1 (en) 1995-09-21
FI105681B (fi) 2000-09-29
PL306157A1 (en) 1995-06-12
GR3030436T3 (en) 1999-09-30
AU686976B2 (en) 1998-02-12
AU8030694A (en) 1995-06-15
RO115800B1 (ro) 2000-06-30
DE59408350D1 (de) 1999-07-08
CN1244525A (zh) 2000-02-16
JPH07242632A (ja) 1995-09-19
CZ309394A3 (en) 1995-11-15
YU48920B (sh) 2002-11-15
HU215593B (hu) 1999-01-28
HRP940967A2 (en) 1997-08-31
EE03192B1 (et) 1999-06-15
HU9403551D0 (en) 1995-02-28
CN1124258C (zh) 2003-10-15
LV11321A (lv) 1996-06-20
BG62487B1 (bg) 1999-12-30
MA23392A1 (fr) 1995-07-01
IL111922A0 (en) 1995-03-15
CO4290426A1 (es) 1996-04-17
CZ286065B6 (cs) 2000-01-12
CA2137525A1 (en) 1995-06-11
HRP940967B1 (en) 1999-12-31
EP0657430A1 (de) 1995-06-14
JP3751041B2 (ja) 2006-03-01
ATE180774T1 (de) 1999-06-15
SV1994000072A (es) 1995-08-09
DZ1831A1 (fr) 2002-02-17

Similar Documents

Publication Publication Date Title
ATE165514T1 (de) Verwendung von inosittriphosphat zur zubereitung von medikamenten
FR2691065B1 (fr) Nouvelles compositions oculaires destinees a la prevention et au traitement de certains troubles de la vision.
NO302362B1 (no) Isopropyl-(2-metoksyetyl)-4-(2-klor-3-cyanofenyl)-1,4-dihydro-2,6-dimetylpyridin-3,5-dikarboksylat, legemidler inneholdende forbindelsen samt dens anvendelse, og mellomprodukt for fremstilling derav
EE04551B1 (et) Optiliselt aktiivne pridl-4H-1,2,4-oksadiasiini derivaat ja selle kasutamine vaskulaarsete haiguste ravis
FI941911A0 (fi) Kondensoidut kinolyylidihydropyridiinit, menetelmä niiden valmistamiseksi ja niiden käyttö lääkeaineissa
DE59010302D1 (de) R-(-)-1-(5-Hydroxyhexyl)-3-methyl-7-propylxanthin, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
ATE116851T1 (de) 5-aryl-3h-1,2,4-triazol-3-one und ihre verwendung in der behandlung neurodegenerativer beschwerden.
DK0523013T3 (da) Anvendelse af benzimidazolin-2-oxo-1-carboxylsyrederivater ved behandling af organiske mentale sygdomme
DK0950053T3 (da) Hidtil ukendte benzoylalkyl.1,2,3,6-tetrahydropyridinderivater
ATE126190T1 (de) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-
PT80521B (en) Process for the preparation of esters of the 1,4-dihydro-2,6-dimethyl-3-(alcoxicarbonyl or alcoxialcoxicarbonyl)-4-(substituted phenyl) pyridin-5-carboxylic acid of stereochemical isomers and pharmaceutically acceptable salts thereof
TH17906A (th) ไอโซโพรพิล-(2-เมธอกซิเอธิล)-4-(2-คลอโร-3-โซยาโน-พีนิล)-1,4-ไดโฮโดร 2,6-ไดเมธิล-พิริมิดิน-3,5-ไดคาร์บอกซิเลต

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees