BG60031B2 - Метод за получаване на производни на метил-хинолин - Google Patents
Метод за получаване на производни на метил-хинолинInfo
- Publication number
- BG60031B2 BG60031B2 BG094121A BG9412191A BG60031B2 BG 60031 B2 BG60031 B2 BG 60031B2 BG 094121 A BG094121 A BG 094121A BG 9412191 A BG9412191 A BG 9412191A BG 60031 B2 BG60031 B2 BG 60031B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- general formula
- carboxylic acid
- hydrogen atom
- methylquinoline
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- SMUQFGGVLNAIOZ-UHFFFAOYSA-N quinaldine Chemical class C1=CC=CC2=NC(C)=CC=C21 SMUQFGGVLNAIOZ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- -1 aromatic carboxylic anhydride Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000005254 oxyacyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000007614 solvation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
По метода се получават производни на метилхинолин с обща формула или техни соли, в която х1 означава водороден атом или несвързана електронна двойка, r1 водороден атом или група с обща формула в която r2 е оксиацилов или хидроксиостатък, а пунктирната линия очертава ароматния пръстен. Методът се осъществява чрез прегрупиране на n-окси производното с обща формула в която r1 има посоченото по-горе значение, с производно на органична карбоксилова киселина, съдържащо халогенен атом, за предпочитане халогеналифатен или ароматен карбоксилов анхидрид, или хлорид на карбоксилова киселина, съдържащ от 1 до 8 въглеродни атома, и редуциране на получения естер с обща формула в която r1 има посоченото по-горе значение, а ас е ацилов остатък, след или преди солватиране на естерната група. 8 претенции
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU893736A HUT54363A (en) | 1989-07-25 | 1989-07-25 | Process for producing pyridyl-methyl-quinolin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60031B2 true BG60031B2 (bg) | 1993-07-30 |
Family
ID=10965289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG094121A BG60031B2 (bg) | 1989-07-25 | 1991-03-25 | Метод за получаване на производни на метил-хинолин |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5166354A (bg) |
| EP (2) | EP0435993A1 (bg) |
| AU (1) | AU619129B2 (bg) |
| BG (1) | BG60031B2 (bg) |
| FI (2) | FI911403A0 (bg) |
| HU (1) | HUT54363A (bg) |
| WO (2) | WO1991001315A1 (bg) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU627609B2 (en) * | 1989-07-25 | 1992-08-27 | Alkaloida Vegyeszeti Gyar | New quinoline derivatives and process for the preparation thereof |
| HUT54363A (en) * | 1989-07-25 | 1991-02-28 | Alkaloida Vegyeszeti Gyar | Process for producing pyridyl-methyl-quinolin derivatives |
| GB9819384D0 (en) | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| US7495879B2 (en) * | 2005-02-04 | 2009-02-24 | Thexton Andrew S | Solid-state magnet control |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2381044A1 (fr) * | 1977-02-17 | 1978-09-15 | Hoffmann La Roche | Procede pour la preparation de mefloquine |
| DE3038504A1 (de) * | 1980-10-11 | 1982-06-03 | Basf Ag, 6700 Ludwigshafen | Neue 4-chinolinmethanderivate, ihre herstellung und verwendung zur darstellung von substanzen mit arzneimittelwirkung |
| US4507482A (en) * | 1982-04-14 | 1985-03-26 | Hoffmann-La Roche Inc. | Purification of mefloquin hydrochloride |
| AU627609B2 (en) * | 1989-07-25 | 1992-08-27 | Alkaloida Vegyeszeti Gyar | New quinoline derivatives and process for the preparation thereof |
| HUT54363A (en) * | 1989-07-25 | 1991-02-28 | Alkaloida Vegyeszeti Gyar | Process for producing pyridyl-methyl-quinolin derivatives |
-
1989
- 1989-07-25 HU HU893736A patent/HUT54363A/hu unknown
-
1990
- 1990-07-20 AU AU60741/90A patent/AU619129B2/en not_active Ceased
- 1990-07-20 WO PCT/HU1990/000050 patent/WO1991001315A1/en not_active Application Discontinuation
- 1990-07-20 EP EP90910862A patent/EP0435993A1/en not_active Withdrawn
- 1990-07-20 EP EP90910866A patent/EP0435995A1/en not_active Withdrawn
- 1990-07-20 WO PCT/HU1990/000049 patent/WO1991001314A1/en not_active Application Discontinuation
- 1990-07-20 US US07/671,916 patent/US5166354A/en not_active Expired - Fee Related
- 1990-07-20 US US07/671,917 patent/US5175297A/en not_active Expired - Fee Related
-
1991
- 1991-03-22 FI FI911403A patent/FI911403A0/fi not_active Application Discontinuation
- 1991-03-22 FI FI911402A patent/FI911402A0/fi not_active Application Discontinuation
- 1991-03-25 BG BG094121A patent/BG60031B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991001315A1 (en) | 1991-02-07 |
| AU619129B2 (en) | 1992-01-16 |
| AU6074190A (en) | 1991-02-22 |
| US5175297A (en) | 1992-12-29 |
| US5166354A (en) | 1992-11-24 |
| WO1991001314A1 (en) | 1991-02-07 |
| EP0435995A1 (en) | 1991-07-10 |
| FI911403A0 (fi) | 1991-03-22 |
| EP0435993A1 (en) | 1991-07-10 |
| HUT54363A (en) | 1991-02-28 |
| FI911402A0 (fi) | 1991-03-22 |
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