BG49707A3 - Method for preparing gallenoic form n- (1- ethyl- 2- pirodidinele)- methyl- 2- metoxy- 5- sulphamoil benzamid - Google Patents
Method for preparing gallenoic form n- (1- ethyl- 2- pirodidinele)- methyl- 2- metoxy- 5- sulphamoil benzamidInfo
- Publication number
- BG49707A3 BG49707A3 BG064985A BG6498584A BG49707A3 BG 49707 A3 BG49707 A3 BG 49707A3 BG 064985 A BG064985 A BG 064985A BG 6498584 A BG6498584 A BG 6498584A BG 49707 A3 BG49707 A3 BG 49707A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- copolymer
- ethyl
- sulphamoil
- pirodidinele
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical compound ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 abstract 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 3
- 230000001476 alcoholic effect Effects 0.000 abstract 3
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 abstract 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 229940050176 methyl chloride Drugs 0.000 abstract 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 abstract 2
- BGRJTUBHPOOWDU-NSHDSACASA-N (S)-(-)-sulpiride Chemical compound CCN1CCC[C@H]1CNC(=O)C1=CC(S(N)(=O)=O)=CC=C1OC BGRJTUBHPOOWDU-NSHDSACASA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 abstract 1
- 125000005395 methacrylic acid group Chemical group 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 229960004940 sulpiride Drugs 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Методът намира приложение в медицината. Чрез него се постига висока степен на абсорбция и равномерност при освобождаването ин витро на активния компонент. Съгласно методd от 70 до 85 % тегл. Сулпирид се впръскват посредством алкохолен разтвор на поливинилпиролидон върху 15 до 20 % тегл. Неутрални зърна, като получените по този начин микрогранули се изсушават и пресяват, след което се прибавя алкохолен разтвор на метакрилови полимери, съдържащ 4 тегл.ч. съполимер на метакрилова киселина и метилметакрилат на 1 тегл.ч. съполимер на етилакрилат, метилметакрилат и метилхлорид на диметиламиноетилметакрилат. Микрогранулите първоначално се сушат с талк, а след това в сушилня при температура 370с, накрая се прибавя алкохолен разтвор на съполимер на етилакрилат, метилметакрилат и метилхлорид на диметиламиноетилметакрилат.1 претенцияThe method is used in medicine. It achieves a high degree of absorption and uniformity in the in vitro release of the active component. According to methodd from 70 to 85% wt. Sulpiride is sprayed by means of an alcoholic solution of polyvinylpyrrolidone on 15 to 20% by weight. Neutral grains, the thus obtained microgranules are dried and sieved, after which an alcoholic solution of methacrylic polymers containing 4 wt. copolymer of methacrylic acid and methyl methacrylate per 1 wt.h. copolymer of ethyl acrylate, methyl methacrylate and methyl chloride of dimethylaminoethyl methacrylate. The microgranules are first dried with talc, and then in a dryer at a temperature of 370C, finally an alcoholic solution of a copolymer of ethyl acrylate, methyl methacrylate and methyl chloride of dimethylaminoethyl methacrylate is added. 1 claim
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8320635A FR2556964A1 (en) | 1983-12-23 | 1983-12-23 | NEW GALENIC FORMS OF SULPIRIDE USED ORALALLY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG49707A3 true BG49707A3 (en) | 1992-01-15 |
Family
ID=9295477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG064985A BG49707A3 (en) | 1983-12-23 | 1984-04-06 | Method for preparing gallenoic form n- (1- ethyl- 2- pirodidinele)- methyl- 2- metoxy- 5- sulphamoil benzamid |
Country Status (38)
| Country | Link |
|---|---|
| EP (1) | EP0147244A1 (en) |
| JP (1) | JPS60139616A (en) |
| KR (1) | KR910004570B1 (en) |
| AR (1) | AR231398A1 (en) |
| AU (1) | AU569516B2 (en) |
| BE (1) | BE899331A (en) |
| BG (1) | BG49707A3 (en) |
| CH (1) | CH659386A5 (en) |
| CZ (1) | CZ262984A3 (en) |
| DD (1) | DD220782A5 (en) |
| DE (1) | DE3412868A1 (en) |
| DK (1) | DK165729C (en) |
| ES (1) | ES8502332A1 (en) |
| FI (1) | FI82603C (en) |
| FR (1) | FR2556964A1 (en) |
| GB (1) | GB2151920B (en) |
| GR (1) | GR79584B (en) |
| HU (1) | HU190924B (en) |
| IE (1) | IE57164B1 (en) |
| IL (1) | IL71470A (en) |
| IN (1) | IN160415B (en) |
| IS (1) | IS1364B6 (en) |
| IT (1) | IT1177655B (en) |
| LU (1) | LU85290A1 (en) |
| MA (1) | MA20088A1 (en) |
| MX (1) | MX7715E (en) |
| NO (1) | NO169575C (en) |
| NZ (1) | NZ207753A (en) |
| OA (1) | OA07700A (en) |
| PH (1) | PH21938A (en) |
| PL (1) | PL144356B1 (en) |
| PT (1) | PT78382B (en) |
| RO (1) | RO89437A (en) |
| SU (1) | SU1478993A3 (en) |
| YU (1) | YU44762B (en) |
| ZA (1) | ZA842573B (en) |
| ZM (1) | ZM2084A1 (en) |
| ZW (1) | ZW6084A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8414220D0 (en) * | 1984-06-04 | 1984-07-11 | Sterwin Ag | Medicaments in unit dose form |
| DE3678643D1 (en) * | 1985-08-16 | 1991-05-16 | Procter & Gamble | PARTICLES WITH CONSTANT RELEASE OF ACTIVE SUBSTANCES. |
| US4853229A (en) * | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
| JPH0791184B2 (en) * | 1988-03-31 | 1995-10-04 | 田辺製薬株式会社 | Controlled release formulation and process for producing the same |
| GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
| FR2762213B1 (en) * | 1997-04-18 | 1999-05-14 | Synthelabo | PHARMACEUTICAL COMPOSITION WITH GASTRIC RETENTION |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
| FR2313915A1 (en) * | 1976-01-26 | 1977-01-07 | Corneille Gilbert | Sustained release vincamine microcapsules - with inert core, vincamine (deriv.) intermediate layer and microporous outer coating |
| US4285665A (en) * | 1978-05-08 | 1981-08-25 | Johnson, Matthey & Co., Limited | Engines |
| FR2453639A1 (en) * | 1979-04-09 | 1980-11-07 | Sanofi Sa | NAFTIDROFURYL-BASED IMMEDIATE-DELAYED RELEASE DRUG COMPOSITION |
| FR2453642A1 (en) * | 1979-04-12 | 1980-11-07 | Sanofi Sa | Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser |
| FR2454804B1 (en) * | 1979-04-26 | 1986-11-21 | Sanofi Sa | DIHYDROERGOTOXIN-BASED MEDICINAL PRODUCT AND PROCESS FOR PREPARING THE SAME |
| FR2470599A1 (en) * | 1979-12-07 | 1981-06-12 | Panoz Donald | IMPROVEMENTS IN PROCESSES FOR THE PREPARATION OF GALENIC SHAPES WITH DELAYED ACTION AND PROGRAMMED RELEASE AND GALENIC FORMS OF MEDICAMENTS THUS OBTAINED |
| SE8003805L (en) * | 1980-05-21 | 1981-11-22 | Haessle Ab | A PHARMACEUTICAL PREPARATION WITH IMPROVED EMISSION PROPERTY |
| JPS5753326A (en) * | 1980-09-17 | 1982-03-30 | Dainippon Printing Co Ltd | Manufacture of biaxially stretching blow molded vessel of saturated polyester |
| FR2492661A1 (en) * | 1980-10-28 | 1982-04-30 | Laruelle Claude | NOVEL GALENIC FORM OF ADMINISTRATION OF METOCLOPRAMIDE, ITS PREPARATION METHOD AND MEDICINAL PRODUCT COMPRISING THIS NOVEL FORM |
| FR2494112B1 (en) * | 1980-11-19 | 1986-01-10 | Laruelle Claude | |
| FR2534139B1 (en) * | 1982-10-07 | 1986-08-29 | Laruelle Claude | NOVEL GALENIC FORM OF SULPIRIDE, METHOD FOR PREPARING SAME, AND MEDICINAL PRODUCT COMPRISING THIS NEW FORM |
-
1983
- 1983-12-23 FR FR8320635A patent/FR2556964A1/en not_active Withdrawn
-
1984
- 1984-03-30 IS IS2900A patent/IS1364B6/en unknown
- 1984-04-02 IE IE817/84A patent/IE57164B1/en not_active IP Right Cessation
- 1984-04-04 MA MA20309A patent/MA20088A1/en unknown
- 1984-04-04 EP EP84400661A patent/EP0147244A1/en not_active Withdrawn
- 1984-04-05 BE BE1/10992A patent/BE899331A/en not_active IP Right Cessation
- 1984-04-05 DE DE19843412868 patent/DE3412868A1/en not_active Withdrawn
- 1984-04-05 CZ CS842629A patent/CZ262984A3/en unknown
- 1984-04-05 NZ NZ207753A patent/NZ207753A/en unknown
- 1984-04-05 ZA ZA842573A patent/ZA842573B/en unknown
- 1984-04-06 JP JP59069883A patent/JPS60139616A/en active Granted
- 1984-04-06 LU LU85290A patent/LU85290A1/en unknown
- 1984-04-06 FI FI841376A patent/FI82603C/en not_active IP Right Cessation
- 1984-04-06 PH PH30510A patent/PH21938A/en unknown
- 1984-04-06 NO NO841367A patent/NO169575C/en unknown
- 1984-04-06 YU YU640/84A patent/YU44762B/en unknown
- 1984-04-06 OA OA58273A patent/OA07700A/en unknown
- 1984-04-06 HU HU841362A patent/HU190924B/en not_active IP Right Cessation
- 1984-04-06 DD DD84261741A patent/DD220782A5/en not_active IP Right Cessation
- 1984-04-06 AR AR296218A patent/AR231398A1/en active
- 1984-04-06 IN IN242/MAS/84A patent/IN160415B/en unknown
- 1984-04-06 GR GR74337A patent/GR79584B/el unknown
- 1984-04-06 PL PL1984247098A patent/PL144356B1/en unknown
- 1984-04-06 GB GB08408978A patent/GB2151920B/en not_active Expired
- 1984-04-06 PT PT78382A patent/PT78382B/en not_active IP Right Cessation
- 1984-04-06 BG BG064985A patent/BG49707A3/en unknown
- 1984-04-06 IT IT48001/84A patent/IT1177655B/en active
- 1984-04-06 CH CH1755/84A patent/CH659386A5/en not_active IP Right Cessation
- 1984-04-06 SU SU843728542A patent/SU1478993A3/en active
- 1984-04-06 DK DK180784A patent/DK165729C/en not_active IP Right Cessation
- 1984-04-07 RO RO84114201A patent/RO89437A/en unknown
- 1984-04-07 KR KR1019840001840A patent/KR910004570B1/en not_active IP Right Cessation
- 1984-04-08 IL IL71470A patent/IL71470A/en unknown
- 1984-04-10 ZW ZW60/84A patent/ZW6084A1/en unknown
- 1984-04-16 MX MX84101994U patent/MX7715E/en unknown
- 1984-04-24 ZM ZM20/84A patent/ZM2084A1/en unknown
- 1984-05-03 ES ES532125A patent/ES8502332A1/en not_active Expired
- 1984-05-31 AU AU28904/84A patent/AU569516B2/en not_active Ceased
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