FR2453642A1 - Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser - Google Patents

Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser

Info

Publication number
FR2453642A1
FR2453642A1 FR7909270A FR7909270A FR2453642A1 FR 2453642 A1 FR2453642 A1 FR 2453642A1 FR 7909270 A FR7909270 A FR 7909270A FR 7909270 A FR7909270 A FR 7909270A FR 2453642 A1 FR2453642 A1 FR 2453642A1
Authority
FR
France
Prior art keywords
plasticiser
anionic
polymers
ergo
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7909270A
Other languages
French (fr)
Other versions
FR2453642B1 (en
Inventor
Hubert Armand
Roland Segonds
Pierre Lotteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR7909270A priority Critical patent/FR2453642A1/en
Publication of FR2453642A1 publication Critical patent/FR2453642A1/en
Application granted granted Critical
Publication of FR2453642B1 publication Critical patent/FR2453642B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Microgranules for oral administration to man or animals liberate dihydroergotoxin methane sulphonate (I) in a controlled manner, independently of the pH. R1 is benzyl (I is ergocristine), or -CH2CHMe2 (I is ergokryptine) or -CHMe2 (I is ergocornine). The microgranules contain a spherical support of inactive material, (I) fixed on the support, and a coating which is a mixture containing two polymers of methacrylic acid, one cationic and one anionic, and a plasticiser. Used for treatment of cerebral circulatory insufficiency, cerebral vascular disorders, arterial hypertension due to age, and peripheral veinous and arteriolo-capillary disorders.
FR7909270A 1979-04-12 1979-04-12 Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser Granted FR2453642A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7909270A FR2453642A1 (en) 1979-04-12 1979-04-12 Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7909270A FR2453642A1 (en) 1979-04-12 1979-04-12 Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser

Publications (2)

Publication Number Publication Date
FR2453642A1 true FR2453642A1 (en) 1980-11-07
FR2453642B1 FR2453642B1 (en) 1982-05-21

Family

ID=9224260

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909270A Granted FR2453642A1 (en) 1979-04-12 1979-04-12 Controlled release of ergo-toxin methane sulphonate - from micro-granules coated with anionic and cationic methacrylic! polymers and a plasticiser

Country Status (1)

Country Link
FR (1) FR2453642A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477015A1 (en) * 1980-03-03 1981-09-04 Fabre Sa Pierre PHARMACEUTICAL COMPOSITION BASED ON ALKALOID OF RYE DARK WITH REGULATORY ACTIVITY ON VASCULAR TONUS
WO1985002114A1 (en) * 1983-11-14 1985-05-23 Societe Anonyme Ethypharm New galenic forms of sulpiride which may be orally administered
EP0147244A1 (en) * 1983-12-23 1985-07-03 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Galenic forms of sulpiride for oral administration
WO1986001717A1 (en) * 1984-09-14 1986-03-27 Pharmatec S.P.A. Controlled release nifedipine preparation
EP0188309A2 (en) * 1985-01-03 1986-07-23 Connaught Laboratories Limited Microencapsulation of living cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1347413A (en) * 1963-01-29 1963-12-27 Italnysco S P A Broad-acting spherules or globules and method for their preparation
GB1175430A (en) * 1966-04-07 1969-12-23 Sandoz Ltd Pharmaceutical Compositions containing Ergot Alkaloids
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1347413A (en) * 1963-01-29 1963-12-27 Italnysco S P A Broad-acting spherules or globules and method for their preparation
GB1175430A (en) * 1966-04-07 1969-12-23 Sandoz Ltd Pharmaceutical Compositions containing Ergot Alkaloids
FR2390959A1 (en) * 1977-05-16 1978-12-15 Prugnaud Robert Synergistic pyrimido:pyrimidine and aspirin compsns. - are anti-aggregating agents and are useful for treating e.g. peripheral vascular disorders

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2477015A1 (en) * 1980-03-03 1981-09-04 Fabre Sa Pierre PHARMACEUTICAL COMPOSITION BASED ON ALKALOID OF RYE DARK WITH REGULATORY ACTIVITY ON VASCULAR TONUS
EP0036350A1 (en) * 1980-03-03 1981-09-23 Pierre Fabre Medicament Pharmaceutical composition having a regulatory effect on vascular tone
WO1985002114A1 (en) * 1983-11-14 1985-05-23 Societe Anonyme Ethypharm New galenic forms of sulpiride which may be orally administered
EP0145558A2 (en) * 1983-11-14 1985-06-19 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Galenic forms of sulpiride for oral administration
EP0145558A3 (en) * 1983-11-14 1985-08-07 Ethypharm, Societe Anonyme Galenic forms of sulpiride for oral administration
EP0147244A1 (en) * 1983-12-23 1985-07-03 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Galenic forms of sulpiride for oral administration
GB2151920A (en) * 1983-12-23 1985-07-31 Ile De France Oral compositions containing sulpiride
AU569516B2 (en) * 1983-12-23 1988-02-04 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Galenic forms of sulpiride for oral use
WO1986001717A1 (en) * 1984-09-14 1986-03-27 Pharmatec S.P.A. Controlled release nifedipine preparation
EP0188309A2 (en) * 1985-01-03 1986-07-23 Connaught Laboratories Limited Microencapsulation of living cells
EP0188309A3 (en) * 1985-01-03 1987-09-02 Connaught Laboratories Limited Microencapsulation of living cells

Also Published As

Publication number Publication date
FR2453642B1 (en) 1982-05-21

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