FR2453641A1 - Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating - Google Patents

Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating

Info

Publication number
FR2453641A1
FR2453641A1 FR7909269A FR7909269A FR2453641A1 FR 2453641 A1 FR2453641 A1 FR 2453641A1 FR 7909269 A FR7909269 A FR 7909269A FR 7909269 A FR7909269 A FR 7909269A FR 2453641 A1 FR2453641 A1 FR 2453641A1
Authority
FR
France
Prior art keywords
controlled release
percent
circulatory
anionic
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7909269A
Other languages
French (fr)
Other versions
FR2453641B1 (en
Inventor
Hubert Armand
Roland Segonds
Pierre Lotteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Priority to FR7909269A priority Critical patent/FR2453641A1/en
Publication of FR2453641A1 publication Critical patent/FR2453641A1/en
Application granted granted Critical
Publication of FR2453641B1 publication Critical patent/FR2453641B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide

Abstract

Microgranules for oral admin. to man or animals liberate naftidofuryl oxalate (I) in a controlled manner. Liberation rate of (I) is as follows: less than 20 percent after 1 hour, 30-50 percent after 4 hours, and over 80 percent after 8 hours. This liberation is independent of pH. The microgranules comprise the following: an inert spherical support 500-600 microns in dia., a deposit of 0.338-0.413 mg of (I) fixed to the support, and a coating over the deposit of (I) contg. a methacrylic acid anionic polymer, the coating being 4-7 wt.% of the uncoated material. (I) is known to have circulatory and metabolic activating activity, and is useful in the treatment of arteriopathies, circulatory disorders, cerebral vascular disorders and circulatory insufficiency. The controlled release of (I) gives reproducible results, liberating large amts. of (I) at a precise area in the stomach or small intestine.
FR7909269A 1979-04-12 1979-04-12 Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating Granted FR2453641A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7909269A FR2453641A1 (en) 1979-04-12 1979-04-12 Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7909269A FR2453641A1 (en) 1979-04-12 1979-04-12 Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating

Publications (2)

Publication Number Publication Date
FR2453641A1 true FR2453641A1 (en) 1980-11-07
FR2453641B1 FR2453641B1 (en) 1982-10-22

Family

ID=9224259

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909269A Granted FR2453641A1 (en) 1979-04-12 1979-04-12 Micro-granules giving controlled release of naftidrofuryl oxalate - having an inert core and an anionic polymethacrylic acid coating

Country Status (1)

Country Link
FR (1) FR2453641A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5687459A (en) * 1992-07-09 1997-11-18 Vanmoor; Arthur Label against shoplifting of garments

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377196A1 (en) * 1977-01-13 1978-08-11 Lipha DRUG COMPOSITION FOR ORAL USE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2377196A1 (en) * 1977-01-13 1978-08-11 Lipha DRUG COMPOSITION FOR ORAL USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5687459A (en) * 1992-07-09 1997-11-18 Vanmoor; Arthur Label against shoplifting of garments

Also Published As

Publication number Publication date
FR2453641B1 (en) 1982-10-22

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Legal Events

Date Code Title Description
TP Transmission of property
CA Change of address
CD Change of name or company name
ST Notification of lapse