BG44707A3 - Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни - Google Patents

Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни

Info

Publication number
BG44707A3
BG44707A3 BG066763A BG6676384A BG44707A3 BG 44707 A3 BG44707 A3 BG 44707A3 BG 066763 A BG066763 A BG 066763A BG 6676384 A BG6676384 A BG 6676384A BG 44707 A3 BG44707 A3 BG 44707A3
Authority
BG
Bulgaria
Prior art keywords
demethyl
oxytetracycline
methylene
derivatives
chlorino
Prior art date
Application number
BG066763A
Other languages
Bulgarian (bg)
English (en)
Inventor
Gyoergy Lugosi
Maria Hima
Maria Bakonyi
Sandor Szoke
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Publication of BG44707A3 publication Critical patent/BG44707A3/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/14Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG066763A 1983-09-02 1984-08-31 Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни BG44707A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU833061A HU188367B (en) 1983-09-02 1983-09-02 Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof

Publications (1)

Publication Number Publication Date
BG44707A3 true BG44707A3 (bg) 1989-01-16

Family

ID=10962342

Family Applications (1)

Application Number Title Priority Date Filing Date
BG066763A BG44707A3 (bg) 1983-09-02 1984-08-31 Метод за получаване на 6-деметил-6-дезокси-6-метилен-5- окситетрациклин и негови 11а-хлорни производни

Country Status (11)

Country Link
US (1) US4659515A (pl)
JP (1) JPS6094950A (pl)
KR (1) KR910004668B1 (pl)
BG (1) BG44707A3 (pl)
DD (1) DD219186A5 (pl)
DE (1) DE3431009A1 (pl)
FR (1) FR2551435B1 (pl)
GB (1) GB2145722B (pl)
HU (1) HU188367B (pl)
IT (1) IT1207343B (pl)
PL (1) PL143307B1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686634A (en) * 1994-07-01 1997-11-11 Pfizer, Inc. Process for producing 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11A-chlorotetracycline
CN104163773B (zh) * 2013-08-30 2016-04-27 郑州后羿制药有限公司 一种四环素的精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB887671A (en) * 1958-03-05 1962-01-24 American Cyanamid Co Preparation of members of the tetracycline series
FR1430859A (pl) * 1960-05-23 1966-05-25
US2984686A (en) * 1960-12-19 1961-05-16 Pfizer & Co C 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines
US3842123A (en) * 1969-08-08 1974-10-15 L Bernardi Methylenetetracycline formate ester
BE755678R (fr) * 1969-09-04 1971-03-03 Farmaceutici Italia Esters de la methylenetetracycline et procede de leur fabrication
CA942743A (en) * 1970-07-03 1974-02-26 Ivan Villax Process for producing 6-methylenetetracyclines and 6-deoxytetracyclines
FR2136137A5 (en) * 1971-04-05 1972-12-22 Pliva Pharm & Chem Works Tetracycline derivs prepn - by bromination followed by dehydration
GB1333900A (en) * 1971-07-08 1973-10-17 Farmaceutici Italia 6-deimethyl-6-deoxytetracycline
ATA571275A (de) * 1974-08-09 1976-06-15 Pliva Pharm & Chem Works Verfahren zur herstellung von 11a-chlor-6-methylen-5-hydroxy-tetracyclin-p-toluolsulfonat

Also Published As

Publication number Publication date
FR2551435A1 (fr) 1985-03-08
GB8422041D0 (en) 1984-10-03
GB2145722A (en) 1985-04-03
HU188367B (en) 1986-04-28
FR2551435B1 (fr) 1989-01-20
IT1207343B (it) 1989-05-17
DD219186A5 (de) 1985-02-27
JPH0344066B2 (pl) 1991-07-04
KR910004668B1 (ko) 1991-07-09
IT8467863A0 (it) 1984-08-30
DE3431009A1 (de) 1985-03-21
DE3431009C2 (pl) 1990-07-26
PL143307B1 (en) 1988-02-29
KR850002457A (ko) 1985-05-13
PL249429A1 (en) 1985-05-07
US4659515A (en) 1987-04-21
HUT35632A (en) 1985-07-29
JPS6094950A (ja) 1985-05-28
GB2145722B (en) 1987-07-08

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