BG40316A3 - Method for purification of dimeric indolenic alkaloids - Google Patents
Method for purification of dimeric indolenic alkaloidsInfo
- Publication number
- BG40316A3 BG40316A3 BG027829A BG2782974A BG40316A3 BG 40316 A3 BG40316 A3 BG 40316A3 BG 027829 A BG027829 A BG 027829A BG 2782974 A BG2782974 A BG 2782974A BG 40316 A3 BG40316 A3 BG 40316A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- stage
- alkaloids
- dimeric
- stages
- sulfate salts
- Prior art date
Links
- 229930013930 alkaloid Natural products 0.000 title abstract 10
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- -1 alkaloid sulfate salts Chemical class 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 150000003467 sulfuric acid derivatives Chemical class 0.000 abstract 2
- 229960003048 vinblastine Drugs 0.000 abstract 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 abstract 2
- 229960004528 vincristine Drugs 0.000 abstract 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 1
- 229940122803 Vinca alkaloid Drugs 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 229930005303 indole alkaloid Natural products 0.000 abstract 1
- 150000002475 indoles Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/409,225 US3932417A (en) | 1973-10-24 | 1973-10-24 | Dimeric indole alkaloid purification process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG40316A3 true BG40316A3 (en) | 1986-11-14 |
Family
ID=23619578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG027829A BG40316A3 (en) | 1973-10-24 | 1974-10-02 | Method for purification of dimeric indolenic alkaloids |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US3932417A (da) |
| JP (1) | JPS5649919B2 (da) |
| AR (1) | AR200542A1 (da) |
| AT (1) | AT342215B (da) |
| BE (1) | BE819663A (da) |
| BG (1) | BG40316A3 (da) |
| CA (1) | CA1030963A (da) |
| CH (1) | CH606022A5 (da) |
| CS (1) | CS177884B2 (da) |
| DD (1) | DD115675A5 (da) |
| DE (1) | DE2442245A1 (da) |
| DK (1) | DK138541B (da) |
| ES (1) | ES431340A1 (da) |
| FR (1) | FR2249090B1 (da) |
| GB (1) | GB1479512A (da) |
| HU (1) | HU170134B (da) |
| IE (1) | IE39669B1 (da) |
| IL (1) | IL45553A (da) |
| NL (1) | NL184110C (da) |
| PH (1) | PH10811A (da) |
| PL (1) | PL95570B1 (da) |
| SE (1) | SE418185B (da) |
| SU (2) | SU884573A3 (da) |
| YU (1) | YU36610B (da) |
| ZA (1) | ZA745355B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178084B (en) * | 1977-05-31 | 1982-03-28 | Richter Gedeon Vegyeszet | New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue |
| US4749787A (en) * | 1986-10-23 | 1988-06-07 | Harbor Branch Oceanographic Institution, Inc. | Process of isolating vinblastine from the plant catharanthis roseus |
| CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| CN100336817C (zh) * | 2005-07-12 | 2007-09-12 | 东北林业大学 | 一种连续中压柱层析制备高纯度硫酸长春碱的方法 |
| CN115124505B (zh) * | 2022-08-01 | 2023-07-18 | 云南中烟工业有限责任公司 | 一种吲哚生物碱类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
| US3205220A (en) * | 1961-10-26 | 1965-09-07 | Lilly Co Eli | Leurosidine and leurocristine and their production |
| US3225030A (en) * | 1965-02-15 | 1965-12-21 | Lilly Co Eli | Method of preparing leurosine and vincaleukoblastine |
| US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
| DE2124023C3 (de) * | 1970-05-27 | 1980-07-10 | Richter Gedeon Vegyeszeti Gyar R.T., Budapest | Verfahren zur selektiven Gewinnung von Vinblastin, Vinleurosin und Vincristin oder von deren Sulfaten |
| BE793336A (fr) * | 1972-12-05 | 1973-04-16 | Richter Gedeon Vegyeszet | Procede pour augmenter le rendement en vincristine lors de l'isolement de la vincristine de parties de la plante vinca rosea l. |
-
1973
- 1973-10-24 US US05/409,225 patent/US3932417A/en not_active Expired - Lifetime
-
1974
- 1974-08-19 IE IE1723/74A patent/IE39669B1/xx unknown
- 1974-08-20 ZA ZA00745355A patent/ZA745355B/xx unknown
- 1974-08-23 PH PH16202A patent/PH10811A/en unknown
- 1974-08-27 IL IL45553A patent/IL45553A/xx unknown
- 1974-08-29 CA CA208,126A patent/CA1030963A/en not_active Expired
- 1974-09-04 DE DE2442245A patent/DE2442245A1/de not_active Withdrawn
- 1974-09-06 FR FR7430292A patent/FR2249090B1/fr not_active Expired
- 1974-09-06 YU YU2405/74A patent/YU36610B/xx unknown
- 1974-09-09 BE BE1006167A patent/BE819663A/xx not_active IP Right Cessation
- 1974-09-12 CH CH1243174A patent/CH606022A5/xx not_active IP Right Cessation
- 1974-09-12 DD DD181067A patent/DD115675A5/xx unknown
- 1974-09-19 AR AR255655A patent/AR200542A1/es active
- 1974-09-24 SU SU742062709A patent/SU884573A3/ru active
- 1974-10-02 BG BG027829A patent/BG40316A3/xx unknown
- 1974-10-18 NL NLAANVRAGE7413724,A patent/NL184110C/xx not_active IP Right Cessation
- 1974-10-22 PL PL1974175028A patent/PL95570B1/pl unknown
- 1974-10-23 GB GB45910/74A patent/GB1479512A/en not_active Expired
- 1974-10-23 DK DK555374AA patent/DK138541B/da not_active IP Right Cessation
- 1974-10-23 SE SE7413357A patent/SE418185B/xx not_active IP Right Cessation
- 1974-10-24 AT AT856974A patent/AT342215B/de not_active IP Right Cessation
- 1974-10-24 ES ES431340A patent/ES431340A1/es not_active Expired
- 1974-10-24 JP JP12329574A patent/JPS5649919B2/ja not_active Expired
- 1974-10-24 CS CS7285A patent/CS177884B2/cs unknown
- 1974-10-24 HU HUEI569A patent/HU170134B/hu unknown
-
1979
- 1979-10-19 SU SU792833053A patent/SU1207396A3/ru active
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