BG17795A3 - Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер - Google Patents
Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктерInfo
- Publication number
- BG17795A3 BG17795A3 BG017051A BG1705170A BG17795A3 BG 17795 A3 BG17795 A3 BG 17795A3 BG 017051 A BG017051 A BG 017051A BG 1705170 A BG1705170 A BG 1705170A BG 17795 A3 BG17795 A3 BG 17795A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- uracylythiocter
- uracylethers
- aminouracyls
- arylpiperazinylalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Communication Cables (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1942405A DE1942405C3 (de) | 1969-08-20 | 1969-08-20 | Arylsubstituierte Piperazinylpropylenaminouracile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG17795A3 true BG17795A3 (bg) | 1973-12-25 |
Family
ID=5743321
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG017052A BG17796A3 (bg) | 1969-08-20 | 1970-08-15 | Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер |
| BG015509A BG17585A3 (bg) | 1969-08-20 | 1970-08-19 | Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер |
| BG017051A BG17795A3 (bg) | 1969-08-20 | 1970-08-19 | Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG017052A BG17796A3 (bg) | 1969-08-20 | 1970-08-15 | Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер |
| BG015509A BG17585A3 (bg) | 1969-08-20 | 1970-08-19 | Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US3957786A (no) |
| AT (2) | AT318651B (no) |
| BE (1) | BE755015A (no) |
| BG (3) | BG17796A3 (no) |
| BR (1) | BR6915466D0 (no) |
| CA (1) | CA956944A (no) |
| CH (2) | CH582173A5 (no) |
| DE (1) | DE1942405C3 (no) |
| DK (1) | DK124031B (no) |
| ES (1) | ES382842A1 (no) |
| FI (1) | FI54479C (no) |
| FR (1) | FR2073300B1 (no) |
| GB (1) | GB1309324A (no) |
| HK (1) | HK23678A (no) |
| HU (1) | HU163664B (no) |
| IE (1) | IE35177B1 (no) |
| IL (1) | IL35121A (no) |
| LU (1) | LU61527A1 (no) |
| NL (1) | NL155014B (no) |
| NO (1) | NO129148B (no) |
| SE (1) | SE386448B (no) |
| SU (1) | SU399130A3 (no) |
| YU (2) | YU36509B (no) |
| ZA (1) | ZA705729B (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| LU74319A1 (no) * | 1976-02-09 | 1977-08-19 | ||
| DE3326118A1 (de) | 1982-08-02 | 1984-02-09 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Pyridopyrimidintrione, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| JPH078795B2 (ja) * | 1989-09-06 | 1995-02-01 | 日立化成工業株式会社 | 排尿障害治療剤 |
| AU7078691A (en) | 1990-02-01 | 1991-08-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Use of urapidile and derivatives for treating arteriosclerotic diseases |
| DE4425143A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
| DE59509727D1 (de) * | 1994-12-07 | 2001-11-22 | Byk Gulden Lomberg Chem Fab | Uracilderivate |
| HUP0104493A3 (en) | 1998-09-30 | 2002-12-28 | Takeda Pharmaceutical | Drugs for improving vesical excretory strength |
| JP2004517081A (ja) * | 2000-11-29 | 2004-06-10 | イーライ・リリー・アンド・カンパニー | １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物 |
| WO2003000664A1 (de) * | 2001-06-22 | 2003-01-03 | Bayer Aktiengesellschaft | Uracilderivative und ihre verwendung bei der behandlung bakterieller erkrankungen |
| US20050058696A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| US20050059744A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| JP5165242B2 (ja) | 2003-09-12 | 2013-03-21 | アラーガン、インコーポレイテッド | 疼痛およびα２アドレナリン受容体が関与する他の状態の処置のための方法および組成物 |
| US20060264442A1 (en) * | 2005-05-18 | 2006-11-23 | Allergan, Inc. | Methods for the treatment of ocular and neurodegenerative conditions in a mammal |
| CN101200451B (zh) * | 2006-12-15 | 2010-12-15 | 重庆药友制药有限责任公司 | 一种盐酸乌拉地尔的制备方法 |
| CN102295607B (zh) * | 2011-06-16 | 2013-04-17 | 郑州大学 | 乌拉地尔的逆相转移催化制备方法 |
| KR102638538B1 (ko) | 2021-12-28 | 2024-02-20 | 주식회사 한서켐 | 우라피딜 제조 중간체의 제조방법 |
| CN115477616A (zh) * | 2022-09-27 | 2022-12-16 | 河北广祥制药有限公司 | 一种乌拉地尔杂质的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2567651A (en) * | 1951-09-11 | J-dialkyl-g-amino-l |
-
0
- BE BE755015D patent/BE755015A/xx not_active IP Right Cessation
-
1969
- 1969-08-20 DE DE1942405A patent/DE1942405C3/de not_active Expired
- 1969-12-19 BR BR215466/69A patent/BR6915466D0/pt unknown
-
1970
- 1970-07-30 CH CH346173A patent/CH582173A5/xx not_active IP Right Cessation
- 1970-07-30 CH CH1150970A patent/CH551990A/xx not_active IP Right Cessation
- 1970-08-13 GB GB3908070A patent/GB1309324A/en not_active Expired
- 1970-08-13 SU SU1670154A patent/SU399130A3/ru active
- 1970-08-14 YU YU02076/70A patent/YU36509B/xx unknown
- 1970-08-15 BG BG017052A patent/BG17796A3/xx unknown
- 1970-08-17 LU LU61527D patent/LU61527A1/xx unknown
- 1970-08-18 IL IL35121A patent/IL35121A/xx unknown
- 1970-08-19 AT AT959571A patent/AT318651B/de not_active IP Right Cessation
- 1970-08-19 HU HUBI373A patent/HU163664B/hu unknown
- 1970-08-19 NO NO03159/70A patent/NO129148B/no unknown
- 1970-08-19 FI FI2271/70A patent/FI54479C/fi active
- 1970-08-19 BG BG015509A patent/BG17585A3/xx unknown
- 1970-08-19 BG BG017051A patent/BG17795A3/xx unknown
- 1970-08-19 AT AT751370A patent/AT302359B/de not_active IP Right Cessation
- 1970-08-19 SE SE7011321A patent/SE386448B/xx unknown
- 1970-08-19 DK DK424770AA patent/DK124031B/da not_active IP Right Cessation
- 1970-08-19 ES ES382842A patent/ES382842A1/es not_active Expired
- 1970-08-20 ZA ZA705729A patent/ZA705729B/xx unknown
- 1970-08-20 CA CA091,177A patent/CA956944A/en not_active Expired
- 1970-08-20 US US05/065,445 patent/US3957786A/en not_active Expired - Lifetime
- 1970-08-20 FR FR7030598A patent/FR2073300B1/fr not_active Expired
- 1970-08-20 NL NL707012364A patent/NL155014B/xx not_active IP Right Cessation
- 1970-08-20 IE IE1084/70A patent/IE35177B1/xx unknown
-
1976
- 1976-04-08 US US05/675,122 patent/US4067982A/en not_active Expired - Lifetime
-
1978
- 1978-05-04 HK HK236/78A patent/HK23678A/xx unknown
-
1979
- 1979-08-20 YU YU02039/79A patent/YU36518B/xx unknown
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