BG17585A3 - Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер - Google Patents

Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер

Info

Publication number
BG17585A3
BG17585A3 BG015509A BG1550970A BG17585A3 BG 17585 A3 BG17585 A3 BG 17585A3 BG 015509 A BG015509 A BG 015509A BG 1550970 A BG1550970 A BG 1550970A BG 17585 A3 BG17585 A3 BG 17585A3
Authority
BG
Bulgaria
Prior art keywords
uracylthioether
uracyls
uracylether
piperazinylalkylamino
preparation
Prior art date
Application number
BG015509A
Other languages
Bulgarian (bg)
English (en)
Inventor
Wolfgang Proesse
Kurt Klemm
Wolfgang Schoetensack
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Publication of BG17585A3 publication Critical patent/BG17585A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Communication Cables (AREA)
BG015509A 1969-08-20 1970-08-19 Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер BG17585A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1942405A DE1942405C3 (de) 1969-08-20 1969-08-20 Arylsubstituierte Piperazinylpropylenaminouracile

Publications (1)

Publication Number Publication Date
BG17585A3 true BG17585A3 (bg) 1973-11-10

Family

ID=5743321

Family Applications (3)

Application Number Title Priority Date Filing Date
BG017052A BG17796A3 (bg) 1969-08-20 1970-08-15 Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер
BG017051A BG17795A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер
BG015509A BG17585A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арил пиперазинилалкиламино- урацили,урацилетер,урацилтиоетер

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BG017052A BG17796A3 (bg) 1969-08-20 1970-08-15 Метод за получаване на субституирани с арилпиперазинилалкиламино- урацили,-урацилетер и урацилитиотер
BG017051A BG17795A3 (bg) 1969-08-20 1970-08-19 Метод за получаване на субституирани с арилпиперазинилалкил- аминоурацили-урацилетери-урацилитиоктер

Country Status (24)

Country Link
US (2) US3957786A (fr)
AT (2) AT318651B (fr)
BE (1) BE755015A (fr)
BG (3) BG17796A3 (fr)
BR (1) BR6915466D0 (fr)
CA (1) CA956944A (fr)
CH (2) CH582173A5 (fr)
DE (1) DE1942405C3 (fr)
DK (1) DK124031B (fr)
ES (1) ES382842A1 (fr)
FI (1) FI54479C (fr)
FR (1) FR2073300B1 (fr)
GB (1) GB1309324A (fr)
HK (1) HK23678A (fr)
HU (1) HU163664B (fr)
IE (1) IE35177B1 (fr)
IL (1) IL35121A (fr)
LU (1) LU61527A1 (fr)
NL (1) NL155014B (fr)
NO (1) NO129148B (fr)
SE (1) SE386448B (fr)
SU (1) SU399130A3 (fr)
YU (2) YU36509B (fr)
ZA (1) ZA705729B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2329399A1 (de) * 1973-06-08 1975-01-02 Wuelfing J A Fa 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
LU74319A1 (fr) * 1976-02-09 1977-08-19
DE3326118A1 (de) 1982-08-02 1984-02-09 Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz Pyridopyrimidintrione, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende arzneimittel
IE62890B1 (en) * 1988-12-06 1995-03-08 Hafslund Nycomed Pharma New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure
CA2024428A1 (fr) * 1989-09-06 1991-03-07 Masayuki Ishikawa Agent pour le traitement de l'obstruction des voies urinaires
WO1991011185A1 (fr) 1990-02-01 1991-08-08 Byk Gulden Lomberg Chemische Fabrik Gmbh Utilisation d'urapidile et derives pour le traitement de maladies arteriosclerotiques
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
AU4302996A (en) * 1994-12-07 1996-06-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Uracil derivatives
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
ATE374192T1 (de) * 2000-11-29 2007-10-15 Lilly Co Eli 1-(2-m-methansulfonamidophenylethyl)-4-(m- trifluoromethylphenyl)piperazine und ihre akzeptablen pharmazeutischen salze und solvate und ihre verwendung zur behandlung von inkontinenz
WO2003000664A1 (fr) * 2001-06-22 2003-01-03 Bayer Aktiengesellschaft Derives d'uracile et leur utilisation pour traiter des maladies bacteriennes
US20050059744A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
KR20060126448A (ko) 2003-09-12 2006-12-07 알러간, 인코포레이티드 통증 및 다른 알파 2 아드레날린 매개 증상을 치료하기위한 방법 및 조성물
US20050058696A1 (en) * 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
US20060264442A1 (en) * 2005-05-18 2006-11-23 Allergan, Inc. Methods for the treatment of ocular and neurodegenerative conditions in a mammal
CN101200451B (zh) * 2006-12-15 2010-12-15 重庆药友制药有限责任公司 一种盐酸乌拉地尔的制备方法
CN102295607B (zh) * 2011-06-16 2013-04-17 郑州大学 乌拉地尔的逆相转移催化制备方法
CN116082250A (zh) * 2021-11-05 2023-05-09 江苏润安制药有限公司 一种新的制备盐酸乌拉地尔的方法
KR102638538B1 (ko) 2021-12-28 2024-02-20 주식회사 한서켐 우라피딜 제조 중간체의 제조방법
CN115477616A (zh) * 2022-09-27 2022-12-16 河北广祥制药有限公司 一种乌拉地尔杂质的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2567651A (en) * 1951-09-11 J-dialkyl-g-amino-l

Also Published As

Publication number Publication date
SU363248A3 (fr) 1972-12-30
FR2073300B1 (fr) 1974-02-01
FR2073300A1 (fr) 1971-10-01
GB1309324A (en) 1973-03-07
SE386448B (sv) 1976-08-09
IL35121A0 (en) 1970-10-30
ZA705729B (en) 1972-03-29
DK124031B (da) 1972-09-04
NL7012364A (fr) 1971-02-23
DE1942405B2 (de) 1973-10-31
IL35121A (en) 1974-03-14
YU36509B (en) 1984-02-29
IE35177L (en) 1971-02-20
BR6915466D0 (pt) 1973-05-15
ES382842A1 (es) 1973-02-16
BG17796A3 (bg) 1973-12-25
CA956944A (en) 1974-10-29
AT318651B (de) 1974-11-11
FI54479B (fi) 1978-08-31
AT302359B (de) 1972-10-10
CH582173A5 (fr) 1976-11-30
FI54479C (fi) 1978-12-11
HU163664B (fr) 1973-10-27
YU36518B (en) 1984-02-29
BE755015A (fr) 1971-02-01
IE35177B1 (en) 1975-12-10
NL155014B (nl) 1977-11-15
CH551990A (de) 1974-07-31
US3957786A (en) 1976-05-18
US4067982A (en) 1978-01-10
HK23678A (en) 1978-05-12
NO129148B (fr) 1974-03-04
DE1942405C3 (de) 1974-05-30
DE1942405A1 (de) 1971-09-16
LU61527A1 (fr) 1971-06-22
BG17795A3 (bg) 1973-12-25
YU207670A (en) 1982-02-25
YU203979A (en) 1982-02-25
SU399130A3 (fr) 1973-09-27

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