BG109669A - Biologically active cosmetic composition - Google Patents

Abstract

The biologically active cosmetic composition will find application in the cosmetic industry for the production of creams, toilet milks and lotions. It helps to recover the disturbed hydro balance by invigorating the regenerative processes and strengthening the protective function of the skin. The specifically selected components have a synergic action û they increase the turgor and improve the appearance of the skin, which becomes sleek and soft. The composition is naturally fragranced by the rose concrete, which makes it suitable for sensitive skin as well. The combination of pearl dust and enriched hydrating emulsion basic mass ensures completeness of the cosmetic characteristics owing to the finely ground pearl dust with preserved biological activity, as well as to the perfectly selected biologically active substances and complexes. The composition according to the invention contains the following ingredients in weight percentage: pearl dust with particle size of 1 to 15 microm of 0.5 to 2.5, antimicrobial complex of biologically active substances û Sodium hyaluronate 2 to 4, urea 2 to 4.5, lauryl lactate 1 to 6, sodium lactate 0.5 to 3, rose concrete (Rosa Damascena) 0.3 to 1.2, biologically active complexes 7 to 21.5, conservants 0.5 to 1.4, oil phase 10.7 to 23, and aqueous phase up to 100.

Description

I. TECHNICAL FIELD

The invention relates to a biologically active cosmetic cbcraeq which will find application in the cosmetic industry for the manufacture of creams, toilet milk and lotions.

• ·

II. BACKGROUND OF THE INVENTION

It is known from BG-108288 biologically active cosmetic composition containing concretion of Rosa Damascena, Rooibos extract, vitamin A palmitate, vitamin E acetate, oil and water phase.

W02006034750 is a cosmetic composition comprising a synergistically effective substance comprising a pearl extract and at least one vitamin or vitamin complex, a plant extract, at least one additional protein or protein hydrolyzate and at least one silicon derivative.

W. TECHNICAL NATURE

The invention relates to a biologically active cosmetic composition containing by weight. % - pearl powder with a particle size of 1 to 15 microns in an amount of 0.5 to 2.5, microbial protection complex based on biologically active substances, such as - Sodium hyaluronate from 2 to 4, Urea 2 to 4,5, Lauryl Lactate from 1 to 6, Sodium Lactate 0.5 to 3, Pink KOHKpeTRosa Damascena 0.3 to 1.2, biologically active complexes in an amount of 7 to 21.5, preservative 0.5 to 1.4, oil phase from 10.7 to 23 and aqueous phase to 100 wt. .%.

The biologically active complexes according to the invention are Hydromanil-Caesalpinia Spinosa, Oligosaccharides, CaesalpiniaSpinosaGum, Glycerin, PropyleneGlycol, Aqua and Sim Glucan-Aqua, Gycerin, Beta-Glucan and Aquaderm SP-Aqua, Sodium Gacite Fructose, Sodiumacin Anosium, Sodiumacin Anosium, and Acuaxyl-Xylitylglucoside, Anhydroxylitol, Xylitol and Sepitonics M3 -Zinc gluconate, Magnesium aspartate, Cupper gluconate and Vitamin Complex LA- Propylene Glycol, Polysorbate20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetlavitone, Retocinotoxidone, Retinotoxide, Pyetonate HCL.

• · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · ·

The biologically active cosmetic composition according to the invention has an oil phase comprising Emulsgad SE -Glyceryl Stearate, Ceteareth-20, Cetearyl-12, Cetearyl Alcohol, Cetyl Palmitate and Transpotol - CG - Ethoxydiglycol and Dow Corning 345Cyclomethiclone 165 Stearate, and Lanet OCetearyl Alcohol, and Dow Corning 200 / R / 350 cst - Dimethicone and the aqueous phase of propylene glycol, glycerin and water.

The production method involves the preparation of two main phases with subsequent steps in a vacuum homogenizer. 70% of the recipe amount of drinking water, glycerin and propylene glycol are dosed in the water phase reactor. Turn on - warm up after about 15 minutes. and an anchor (propeller) stirrer. The mass is heated to a temperature of 70 ° - 75 ° C. The pre-weighed quantities are put into the oil phase reactor - Dow Corning 350 / R / 350cst, Dow Corning 345, Lanet O, Emulsgad SE, Simulsol 165, Trasgutol CG, Shercemol LL . Warm up in the jacket of the reactor and after 10 minutes. the anchor mixer is included. A preheat temperature of 75 ° - 80 ° C is set and when it is reached 5 minutes before the suction phase, a pink concretion is added to the homogenizer. In addition, the remaining 30% of the recipe amount of drinking water is dosed in a suitable container, and the pre-stretched urea formulation is added to it. Mix with a suitable stirrer until the granule is dissolved. When the urea is dissolved, the temperature of the solution decreases. In a suitable volume and according to the intended purpose, the recipe quantities of the mixture of biologically active substances are dosed: Sim Glucan, Aquaderm SP, Hydromanil, Sepitonik M , Acuaxil, Sodium lactad, Sodium hyaluronate, Vitamin Complex LA, Sepitzitz HB. Mix until the homogeneity of the components. The powder phase is followed by weighing the recipe amount of pearl powder in a suitable container in volume and geometry.

In the preheated homogenizer, the aqueous and then the oil phase are sucked in successively under vacuum. After the oil phase enters, the suction phase of the powder is followed, followed by the urea solution, and the blend of biologically active substances is slowly sucked into the emulsifying mass. After a series of technological operations under the respective technological regimes, the finished cosmetic composition is packaged.

According to the invention, the active ingredient is pearl powder whose biological activity is due to the presence of a protein complex called conchioline complex, as well as free amino acids and some carbohydrates. is also a biocalcium found in the mussel bound to calcium carbonate. The calcium included in the pearl powder has very good bioavailability due to its specific crystalline modification of aragonite. Aragonite easily repairs the deficiency of this important element, calcium in the body.

The pearl powder used according to the invention is obtained after a precision treatment leading to extremely fine particles of 1 to 15 microns in size, while retaining all biologically active characteristics which have an extremely beneficial effect on the skin. . Proof of this is the attached data:

Radiographs showing the presence of CaCO3, analysis of which shows the presence of peaks corresponding to the crystal structure of aragonite.

FIG. 1: X-ray

Differential thermal analysis (DTA) and thermogravimetric analysis (TG).

• · · · ·

80-1

A

Oh

X

F.

706050403020 '20 4 ---- 1 ---- 1 — ί ---- 1 ---- · ---- 1 ---- 1 ---- 1 ---- r — 1-- --1 ---- ιΟ 100 200 300 <400 500 600

T, ° C

FIG. 2: Differential thermal analysis (DTA), Perkin Elmer apparatus -

FIG. 3: Thermogravimetric Analysis (TG) - Perkin Elmer apparatus

• · • Pearl powder contains 3.7% by weight. % proteins;

• decomposition temperature is about 200 ° C;

• the decomposition temperature of CaCO3 is in the range 535-540 ° C.

The electron microscope image below shows the layered structure of the pearl dust particles. The protein complex is embedded in the spaces between the individual layers of calcium carbonate.

The pearl powder has also been subjected to studies on the content of heavy metals by atomic absorption analysis. The data are presented in a table:

Talb 1: Content of heavy metals

Element Content, mg / kg Norm, mg / kg Copper (C) 21.0 50.0 Tin (Pb) 0.8 10.0 ApceH (As) 0.1 2.0 Bismuth (B1) is not proven it is not allowed Mercury (^) is not proven it is not allowed

Cadmium (Sat) not proven not allowed

The analyzes show that the pearl powder of the invention can be used for cosmetic purposes.

STANDARDIZING PEARL POWDER

Color: white to white with a slight gray tint.

Odor: none

Taste: none

CaCO3 content: 93 to 96% aragonite

Organic content: 3 to 5%

Moisture content: 2 to 3%

Particle size: up to 15 microns

Heavy metals content: Bi, Hg and Cd are not allowed

Si up to 50 mg / kg

Rdo 10mg kg

As up to 2 mg / kg

Solubility in water: insoluble

Clinical trials of the biologically active cosmetic composition according to the patent:

RESEARCH ON IRRITATIVE PROPERTIES OF THE COSMETIC PREPARATION BY A SERIES OF TESTS

Single Closed Epicutaneous Occlusion Test

The test was performed without first performing an open single and multiple test, given the characteristics of the cosmetic product, such as • · ft · · potentially non-irritating one. Although the formulation of the preparation is new, the reason to go directly to closed-type tests is the content of components used in other formulations of similar composition and purpose that are not expected to have an aggressive effect on the skin.

50 individuals with no prior or present skin diseases, aged between 18 and 47, were examined. An application of 0.1 ml of the cosmetic by the closed method (with Finn Chamber 1.2 cm ² ) was applied to the back of the whole preparation without dilution. The test was left on the skin for 48 hours. The results were reported 1,24,48 and 72 hours after the test was taken. A scale for graded, graded erythema and edema was used. The results obtained are presented in Table 1:

Table 1.

Results of a single closed epicutaneous test with "SERUM" - emulsion containing pearl powder in 50 volunteers

Indicators Eritema -> Eshara Swelling 0 1 2 3 4 0 1 2 3 4 After 1 hour: - Number of reactions 50 0 0 0 0 50 0 0 0 0 - Percentage (%) 100 0 0 0 0 100 0 0 0 0 In 24 hours: - Number of reactions 50 0 0 0 0 50 0 0 0 0 - Percentage (%) 100 0 0 0 0 100 0 0 0 0 After 48 hours: - Number of reactions 50 0 0 0 0 50 0 0 0 0 - Percentage (%) 100 0 0 0 0 100 0 0 0 0

• · 4 · ·

After 72 hours: - Number of reactions 50 0 0 0 0 50 0 0 0 0 - Percentage (%) 100 0 0 0 0 100 0 0 0 0

Erythema to formation of eschar = missing = slight redness, barely noticeable = well-defined redness = moderate to severe redness = dark red field to formation of eschar, impeding erythema reading

Edema = missing = very slight edema, barely noticeable = slight edema, edges formed in the field = moderate edema, raised approximately 1 mm = strong edema, raised above 1 mm and extending beyond the boundaries of the exposure field

The data in Table 1 demonstrate the absence of irritation with a single closed application for 48 hours of the preparation on the skin.

CLOSED EPICUTE TEST WITH MULTIPLE APPLICATION UNDER occlusion

The study was conducted on 50 healthy subjects without previous or present skin diseases, aged between 18 and 47 years. The impact site is on the back. The cosmetic product was applied five times over the same area in the

A complete, non-diluted, closed-type species (with Finn Chamber 1.2 cm) occluded at intervals as follows:

Day 1 - 24 hours

Day 2 - »day 5-23.5 h (requirement: not less than 6 hours) ··· ft ··· ft ··« .4 * 0 • · * ft · ft ft ft · ft ft ft · ft ft ft · • ft · «

The product is removed from the skin by washing with water or gently with a swab. Before each subsequent application, the treated area is examined for any abnormal skin reactions. Final counting was performed on the 8th day (72 hours after the last test was taken) with evaluation of erythema, flakiness (dryness) and swelling on appropriate scales. The results are presented in Table 2:

Table 2.

Results of a closed epicutaneous multiple-occlusion test with SERUM - emulsion containing pearl powder in 50 volunteers

Erythema Peeling / dryness Swelling Indicators 0 1 2 3 4 0 1 2 3 4 - Final evaluation (day 8): - Number of reactions 50 0 0 0 0 50 0 0 0 0 50 0 - Percentage (%) 100 0 0 0 0 100 0 0 0 0 100 0

Erythema = missing = slight redness, barely noticeable = well-defined redness = moderate to severe redness = severe redness

Peeling / dryness = missing peeling = fine, barely noticeable peeling = weak peeling = moderate peeling = heavy peeling with large squares

The results show no irritant effect on repeated application of the preparation to the skin.

Swelling

- = missing edema + = presence of edema

The above-mentioned clinical trials prove the extremely good performance of the biologically active cosmetic composition of the patent relating to skin safety and human health.

The biologically active cosmetic composition according to the invention has a special purpose - to restore impaired hydrobalance, enhancing regenerative processes and enhancing the protective function of the skin.Specially selected components acting synergistically in the direction of increasing turgur and improving the appearance of the skin, making the skin smooth and soft. The composition is naturally flavored with the pink concretion, which makes it suitable for sensitive skin as well.

The combination of pearl powder and enriched hydrating emulsion base mass provides a complex of extremely good cosmetic characteristics due to the finely ground pearl powder while maintaining its biologically active properties, as well as the extremely well selected biologically active substances and complexes.

IV EXAMPLE IMPLEMENTATION

Example 1; The composition according to the invention is an emulsion

Oil / Water.Production is carried out by preparing two main phases with subsequent action in a vacuum homogenizer.

• · · · · · · · · · · ·

12 ··

1. Phase preparation:

1.1. Water

70% of the recipe amount of drinking water, glycerin and propylene glycol are dosed in the water phase reactor. Turn on the heat after about 15 minutes. and an anchor (propeller) stirrer. The mass is heated to a temperature of 70 ° - 75 ° C.

1.2. Oil

The pre-weighed quantities are put into the oil phase reactor - Dow Corning 350 / R / 350cst, Dow Corning 345, Lanette O, Emulgad SE, Simulsol 165, Traspotol CG, Shersemol LL. The reactor jacket is warmed up and the anchor mixer is turned on after 10 minutes. A preheat temperature of 75 ° - 80 ° C is set and, when it is reached, 5 minutes before the phase suction in the homogenizer, a prescription amount of pink conc is added.

1.3. Additional:

1.3.1. Urea solution

The remaining 30% of the recipe amount of drinking water is dosed in a suitable container, and the pre-stretched urea formulation is added to it. Mix with a suitable stirrer until the granule is dissolved.

3.2.A mixture of biologically active substances

In a suitable volume and according to the intended purpose, the dosage amounts are consistently dosed: Sim Glucan, Aquaderm SP, Hydromanil, Sepitonik M3, Aquaxil, Sodium lactad, Sodium hyaluronate, Vitamin complex LA, Sepicid HB. Mixed up to homogeneity of components.

1.3.3. Powder phase

Weigh the recipe amount of pearl powder in a suitable volume and geometry container.

2. Production of the semi-factory

In the preheated homogenizer, the aqueous and then the oil phase are sucked in successively under vacuum. With the admission of the first amounts of water phase, the anchor mixer is engaged at first speed. Shortly before the oil phase is sucked in, the high speed mixer is switched on at first speed and the anchor mixer switched to second gear. With the increase «

at the level (on the table) in the homogenizer and the high-speed mixer switches to a second speed.

After entering the oil phase, the high-speed homogenizer is switched to 1st speed and cooled into the homogenizer jacket, set to 60 ° C.

When it is reached at a slow speed, the suction phase of the powder phase begins, followed by the urea solution. A new cooling value of 42 ° C is set, the anchor mixer is switched to first gear.

When the set temperature is reached, the blend of biologically active substances is slowly sucked into the emulsifying mass.

After all phases have been received, stirring is continued only on an anchor stirrer at first speed for 10-15 minutes or more in the presence of a good vacuum. This depends on the state of the Emulsion, which is observed visually through the observation hatch or by direct control of the sample extracted from the homogenizer. The end of this process also depends on the output temperature of the semi-fabricated plant. Two or three degrees before stopping this value stops cooling. in the homogenizer jacket as the system has a degree of inertia.

The mass is removed at 35 ° C in aging vessels to be sampled for analysis after 24 h.

They are then packaged in a product pump package and placed in an ESC, packed in three-ply corrugated boxes or by grouping in another type of transport package (shrink film and cardboard backing).

The quantitative composition (wt%) of the components of Example 1 is given in Table 1.

Table 1

No Trade name Chemical name Name by INCI Quantity 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- -triol Glycerin 5.4 03 Emulgad SE Glyceryl Stearate, 5.5

Ceteareth - 20, 04 Propylene glycol 1,2- Ceteareth - 12, Cetearyl Alcohol, Cetyl Palmitate Propylene Glycol 3.5 05 Hydromanil propanediol Caesalpinia Spinosa 2.0 06 Sodium hyaline- Sodium hya- Oligosaccharides, Caesalpinia Spinosa Gum, Glycerin, Propylene Glycol, Aqua Sodium hyaluronate 2.5 07 ronate, 1% Urea luronate Carbonyldia 2.9 08 Chercemol LL mine Urea Lauryl Lactate 6.0 09 Sim Glucan Aqua, Gycerin, 1.0 10 Transpotol - CG 2- (2-Ethoxy Beta-Glucan 1.8 11 Aquaderm SP ethoxy) ethanol Ethoxydiglycol Aqua, 5.0

Sodium PC A,

Sodium Lactate,

Fructose, 12 Dow Corning 345 Glycine, Niacinamide, Urea, Inositol Cyclomethicone 1.8 13 Acouxyl Xylitylglucoside, 2.1 14 Simulsol 165 Anhydroxylitol, Xylitol Glyceryl Stearate, 1.5 15 Lanet 0 Fatty alcohol PEG -100 Stearate Cetearyl Alcohol 2.5 16 Pearl dust Pearl powder 0.5 17 Sepitonics M3 Zinc gluconate Zinc gluconate, 0.9 18 Sodium lactad Magnesium aspartate Cupper gluconate Sodium -S - (-) - Magnesium aspartate, Cupper gluconate Sodium Lactate 2.2 19 Vitamin Com- 2- hydroxy propionate Propylene Glycol, 0.6 plexus LA Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate,

• ·

Retinyl Palmitate,

Bioflavonoids,

Biotin,

Pyridoxine HCL

HB Sepicidus

Mixture: 2-phe Phenoxyethanol,

0.5

noxyethanol / Methylparaben, pa Ethylparaben, rabens Propylparaben, Butylparaben 22 Dow Corning 200 Dimethicone 0.4 / R / 350 cst 23 Pink Concrete Rosa Damascena 0.5

Example 2:

The manufacturing method is as in Example 1, and the quantitative composition of the components is given in Table 2.

Table 2

No Trade name Chemical name Name by INCI Quantity 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- -triol Glycerin 4.0 03 Emulgad SE Glyceryl Stearate, 8.5

Ceteareth - 20,

Ceteareth - 12, • ♦ • · · · · · · · ·

1 * P ··

Cetearyl Alcohol,

Propylene glycol 1,2propanediol

Cetyl Palmitate

Propylene Glycol 3.7

Hydromanil

Caesalpinia Spinosa 3.1

Oligosaccharides, Caesalpinia Spinosa

Gum, Glycerin,

Propylene Glycol,

Aqua

06 Sodium hyaluronate, 1% Sodium hyaluronate Sodium hyaluronate 4.0 07 Urea Carbonyldia mines Urea 2.0 08 Chercemol LL Lauryl Lactate 5.8 09 Sim Glucan Aqua, Gycerin, Beta-Glucan 1.8 10 Transo l - CG 2- (2-Ethoxy ethoxy) ethanol Ethoxydiglycol 2.2 11 Aquaderm SP Aqua, 4.1

Sodium PCA,

Sodium Lactate,

Fructose,

Glycine,

• • • · · · · • · · · · • · · · · • · · · · · · · ····· ·· ·· • · · ♦ • · · • · · · · • · · · · • · · · is · ·· Niacinamide, Urea, Inositol 12 Dow Corning 345 Cyclomethicone 2.0 13 Acouxyl Xylitylglucoside, Anhydroxylitol, Xylitol 3.0 14 Simulsol 165 Glyceryl Stearate, 1.0 PEG -100 Stearate 15 Lanet 0 Fatty alcohol Cetearyl Alcohol 1.1 16 Pearl dust Pearl powder 0.7 17 Sepitonics M3 Zinc gluconate Zinc gluconate, 2.5 Magnesium Magnesium aspartate aspartate, Cupper gluconate Cupper gluconate 18 Sodium lactad Sodium -S - (-) - 2-hydroxy propionate Sodium Lactate 0.5 19 Vitamin Com- Propylene Glycol, 0.9 plexus LA Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL

• · · ·

19 · · '

20 HB Sepicidus Mixture: 2-phe Phenoxyethanol, noxyethanol / Methylparaben, Well Ethylparaben, rabens Propylparaben, Butylparaben 22 Dow Corning 200 Dimethicone / R / 350 cst 23 Pink concrete Rosa Damascena

0.7

2.4

1.2

Example 3:

The manufacturing method is as in Example 1, and the quantitative composition of the components is given in Table 3.

Table 3

No Trade name Chemical name Name by INCI Quantity 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- 6.1 -triol Glycerin 03 Emulgad SE Glyceryl Stearate, 6.6 Ceteareth - 20, Ceteareth -12, Cetearyl Alcohol,

Cetyl Palmitate

Propylene glycol 1,2- Propylene Glycol 4.3 propanediol

Hydromanil

• ·

Caesalpinia Spinosa 2.2 Oligosaccharides, Caesalpinia Spinosa Gum, Glycerin,

Propylene Glycol, Aqua

06 Sodium hyaluronate, 1% Sodium hyaluronate Sodium hyaluronate 2.2 07 Urea Carbonyldia mines Urea 4.5 08 Chercemol LL Lauryl Lactate 1.0 09 Sim Glucan Aqua, Gycerin, Beta-Glucan 2.3 10 Transo l - CG 2- (2-Ethoxy ethoxy) ethanol Ethoxydiglycol 2.8 11 Aquaderm SP Aqua, 2.5

Sodium PC A

Sodium Lactate,

Fructose,

Glycine,

Niacinamide,

Urea,

Dow Corning 345

Inositol

Cyclomethicone

2.7 • ·

• * • · · · · · · · · · · · · ·

• · · · · · · · · · · 2G '' 13 Acouxyl Xylitylglucoside, Anhydroxylitol, Xylitol 1.0 14 Simulsol 165 Glyceryl Stearate, 2.8 PEG -100 Stearate 15 Do it Fatty alcohol Ceteaiyl Alcohol 2.5 16 Pearl dust Pearl powder 0.9 17 Sepitonics M3 Zinc gluconate Zinc gluconate, 0.5 Magnesium Magnesium aspartate aspartate, Cupper gluconate Cupper gluconate 18 Sodium lactad Sodium -S - (-) - Sodium Lactate 1.7

2- hydroxy propionate

Vitamin Complex LA

Propylene Glycol, Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL

3.0

20 HB Sepicide Mixture: 2-phe Phenoxyethanol, 1.1 noxyethanol / Methylparaben, Well Ethylparaben, rabens Propylparaben, Butylparaben

• • • · · · · · · · · · · · · · · · · · · · · · · • · · · · · · · ·. · • ·· ····· ......... 22 ** ** 22 Dow Corning 200 Dimethicone 1.7 / R / 350 cst 23 Pink concrete Rosa Damascena 0.8

Example 4:

The manufacturing method is as in Example 1, and the quantitative composition of the components is given in Table 4.

Table 4

No Trade name Chemical name Name by INCI Quantity 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- -triol Glycerin 7.0 03 Emulgad SE Glyceryl Stearate, 7.1

Ceteareth - 20,

Ceteareth - 12,

Cetearyl Alcohol,

Propylene glycol 1,2propanediol

Hydromanil

Cetyl Palmitate Propylene Glycol 3.9

Caesalpinia Spinosa 2.9 Oligosaccharides, Caesalpinia Spinosa Gum, Glycerin, Propylene Glycol, Aqua

06 Sodium hyaluronate, 1% Sodium hyaluronate Sodium hyaluronate 2.9 07 Urea Carbonyldia mines Urea 3.6 08 Chercemol LL Lauryl Lactate 4.3 09 Sim Glucan Aqua, Gycerin, Beta-Glucan 4.0 10 Transpotol - CG 2- (2-Ethoxy ethoxy) ethanol Ethoxydiglycol 1.5 11 Aquaderm SP Aqua, 3.3

Dow Corning 345

Acouxyl

Simulsol 165

Sodium PC A,

Sodium Lactate,

Fructose,

Glycine,

Niacinamide,

Urea,

Inositol

Cyclomethicone2.5

Xylitylglucoside, 2.4

Anhydroxylitol,

Xylitol

Glyceryl Stearate, 2.1

PEG -100 Stearate

• · · · ·

15 Lanet 0 Fatty alcohol Cetearyl Alcohol 1.9 16 Pearl dust Pearl powder 2.2 17 Sepitonics M3 Zinc gluconate Magnesium aspartate Cupper gluconate Zinc gluconate, Magnesium aspartate, Cupper gluconate 1.2 18 Sodium lactad Sodium -S - (-) - 2- hydroxy propionate Sodium Lactate 1.1 19 Vitamin Com- plexus LA Propylene Glycol, Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL 2.5 20 Sepicid HB Mixture: 2-phe noxyethanol / pa rabens Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben 1.0 22 Dow Corning 200 / R / 350 cst Dimethicone 2.1 23 Pink concrete Rosa Damascena 0.3

• · * ♦ · f * * · • · · · ♦ · · f · 9 ··· · • · · ·· · »♦ · • · ··· • · · • · · · ··

Example 5:

The production method is as in Example 1 and the quantitative composition of the components

is given in Table 5. Table 5 No Commercial Chemical Name no Quantity name name INCI 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- 5,3 -triol Glycerin 03 Emulgad SE Glyceryl Stearate, 5.9 Ceteareth - 20, Ceteareth- 12, Cetearyl Alcohol, Cetyl Palmitate 04 Propylene glycol 1,2propanediol Propylene Glycol 4.4 05 Hydromanil Caesalpinia Spinosa Oligosaccharides, Caesalpinia Spinosa Gum, Glycerin, Propylene Glycol, Aqua 3.6 06 Sodium hyaline- Sodium hya- Sodium hyaluronate 3.5 ronate, 1% luronate 07 Urea Carbonyldia 3.1 mine Urea 08 Chercemol LL Lauryl Lactate 5.2

J

09 Sim Glucan Aqua, Gycerin, Beta-Glucan 2.7 10 Transpotol - CG 2- (2-Ethoxy ethoxy) ethanol Ethoxydiglycol 1.9 11 Aquaderm SP Aqua, Sodium PCA, Sodium Lactate, Fructose, Glycine, Niacinamide, Urea, Inositol 2.9 12 Dow Corning 345 Cyclomethicone 1.9 13 Acouxyl Xylitylglucoside, Anhydroxylitol, Xylitol 1.3 14 Simulsol 165 Glyceryl Stearate, PEG -100 Stearate 3.0 15 Lanet 0 Fatty alcohol Cetearyl Alcohol 2.4 16 Pearl dust Pearl powder 1.1 17 Sepitonics M3 Zinc gluconate Magnesium aspartate Zinc gluconate, Magnesium aspartate, 0.6

i ....................- U —...........

Cupper gluconate • a · · · · · · · · · · · · · · · · · · · · · · · · • · · · · · · · ·

Cupper gluconate

18 Sodium lactad Sodium - S - (-) - 2- hydroxy propionate Sodium Lactate 3.0 19 Vitamin Com- plexus LA Propylene Glycol, Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL Talc 1.7 20 Sepicid HB Mixture: 2-phe noxyethanol / pa rabens Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben 0.9 22 Dow Corning 200 / R / 350 cst Dimethicone 1.8 23 Pink concrete Rosa Damascena 0.7

Example 6:

The manufacturing method is as in Example 1, and the quantitative composition of the components is given in Table 6.

• ·

Table 6

No Trade name Chemical name Name by INCI Quantity 1 2 3 4 5 01 Water Aqua Up to 100 02 Glycerin 1,2,3-rhorape- -triol Glycerin 4.5 03 Emulgad SE Glyceryl Stearate, 7.8

Ceteareth - 20,

Ceteareth - 12,

Cetearyl Alcohol,

Propylene glycol 1,2propanediol

Hydromanil

Cetyl Palmitate Propylene Glycol 4.5

Caesalpinia Spinosa 4.0 Oligosaccharides, Caesalpinia Spinosa Gum, Glycerin, Propylene Glycol,

Aqua

06 Sodium hyaluronate, 1% Sodium hyaluronate Sodium hyaluronate 2.0 07 Urea Carbonyldia mines Urea 2.3 08 Chercemol LL Lauryl Lactate 3.3 09 Sim Glucan Aqua, Gycerin, Beta-Glucan 3.2

4 -.....

Transpotol - CG 2- (2-Ethoxy ethoxy) ethanol

3.6

Ethoxydiglycol

Aquaderm SP

Aqua,

4.2

Sodium PC A,

Sodium Lactate,

Fructose,

Dow Corning 345

Acouxyl

Simulsol 165

Lanet Oh

Pearl dust

Sepitonics M3

Zinc gluconate Magnesium aspartate Cupper gluconate

Glycine,

Niacinamide,

Urea,

Fatty alcohol

Inositol

Cyclomethicone3.0

Xylitylglucoside, 2.8

Anhydroxylitol,

Xylitol

Glyceryl Stearate, 1.9

PEG -100 Stearate

Cetearyl Alcohol0.5

Pearl powder2.5

Zinc gluconate, 1.9

Magnesium aspartate,

Cupper gluconate

• ·

18 Sodium lactad Sodium -S - (-) - 2-hydroxy propionate Sodium Lactate 2.1 19 Vitamin Complex LA Propylene Glycol, Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL 2.1 20 Sepicid HB Mixture: 2-phe noxyethanol / pa rabens Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben 1.4 22 Dow Corning 200 / R / 350 cst Dimethicone 1.3 23 Pink concrete Rosa Damascena 0.6

♦ ·

Indicators for purity and microbiological control of the biologically active cosmetic composition according to Examples Nos. 1,2,3,4,5 and 6:

Name of indicators

Characteristics and norms

4.1. Organoleptic:

4.1.1. Appearance

4.1.2. Color

4.1.3. The smell

Creamy, homogeneous. mass

White, standard

Rose-floral, standard

4.2. Physico-chemical:

4.2.1. Emulsion type

M / B

4.2.2. pH

6.0 to 7.5

4.2.3. Emulsion stability

4.2.4. Content of heavy metals, mg / kg product, not more than:

4.2.4.1

4.2.4.2 Lead

4.2.4.3

4.2.4.4. Bismuth, Zivak, Cadmium

4.2.5. Identity for Urea

4.2.6. Thermostability at temp. From minus 10 ° C at temp. Up to plus 40 ° C

It does not stratify

50.0

10,0

2.0

Not available

Positive reaction

It does not stratify

It does not stratify

4.3. Microbial content, CFU / ml product, not more than:

4.3.1. Heterotrophic Microorganisms 1000

4.3.2. Molds and Yeasts 500

4.3.3. Conditionally pathogenic and pathogenic microorganisms in 0.1 ml of product

Not available

from the family / enterobacteriacea and types of staphylococcus aureus and pseudomonas aeruginosis /

Claims (4)

A biologically active cosmetic composition comprising an oily and aqueous phase concreted by Rosa Damascena, characterized in that it contains (in% by weight) and pearl powder with a particle size of from 1 to 15 microns and in an amount of from 0.5 to 2.5, , microbial protection complex from biologically active substances - Sodium hyaluronate from 2 to 4, Urea 2 to 4,5, Lauryl Lactate from 1 to 6, Sodium Lactate from 0.5 to 3, Pink KOHKpeTRosa Damascena 0.3 to 1,2, biologically active complexes in the amount from 7 to 21.5, the preservative from 0.5 to 1.4, the oil phase from 10.7 to 23 and the aqueous phase to 100% by weight. The biologically active cosmetic composition according to claim 1, characterized in that the biologically active complexes are Hydromanil-Caesalpinia Spinosa, Oligosaccharides, CaesalpiniaSpinosaGum, Glycerin, PropyleneGlycol, Aqua and Sim Glucan-Aqua, Gycerin, Beta-Glucan and Aquaderm SP-Aqua, Sodium PC A Sodium Lactate, Fructose, Glycine, Niacinamide, Ucosyl Alyl, Anhydyl, Anhydyl, Inylate, Anylyl, Anhydyl Xylitol and Sepitonics M3 -Zinc gluconate, Magnesium aspartate, Cupper gluconate and Vitamin Complex LA- Propylene Glycol, Polysorbate 20, Panthenol, Linoleic Acid, Linolenic Acid, Tocopheryl Acetate, Retinyl, Palmitate, Bioflavonoids, Biotin, Pyridoxine HCL. Biologically active cosmetic composition according to claim 1, characterized in that the oily phase comprises Emulsgad SE -Glyceryl Stearate, Ceteareth-20, Cetearyl-12, Cetearyl Alcohol, Cetyl Palmitate and Transgtotol-CG - Ethoxydiglycol and Dow Corning 34 Cyclomethicone and Simulsol 165-Glyceryl Stearate PEG - 100 Stearate, and Lanet O-Cetearyl Alcohol, and Dow Corning 200 / R / 350 cst Dimethicone. The biologically active cosmetic composition according to claim 1, characterized in that the aqueous phase contains propylene glycol, glycerin and water.