BG108183A - Селективни към топоизомераза i цитотоксични захаридни производни на индолопиролокарбазоли - Google Patents

Селективни към топоизомераза i цитотоксични захаридни производни на индолопиролокарбазоли

Info

Publication number
BG108183A
BG108183A BG108183A BG10818303A BG108183A BG 108183 A BG108183 A BG 108183A BG 108183 A BG108183 A BG 108183A BG 10818303 A BG10818303 A BG 10818303A BG 108183 A BG108183 A BG 108183A
Authority
BG
Bulgaria
Prior art keywords
indolopyrrolocarbazoles
topoisomerase
sugar derivatives
selective cytotoxic
sugar
Prior art date
Application number
BG108183A
Other languages
English (en)
Inventor
Edward H. Ruediger
Mark G. Saulnier
Francis Beaulieu
Carol Bachand
Neelakantan Balusubramanian
Byron H. Long
David B. Frennesson
Kurt Zimmerman
Narasimhulu B. Naidu
Karen Stoffan
Denis R. St.laurent
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BG108183A publication Critical patent/BG108183A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
BG108183A 2001-03-22 2003-09-18 Селективни към топоизомераза i цитотоксични захаридни производни на индолопиролокарбазоли BG108183A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27804301P 2001-03-22 2001-03-22
PCT/US2002/008819 WO2002077255A1 (en) 2001-03-22 2002-03-22 Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles

Publications (1)

Publication Number Publication Date
BG108183A true BG108183A (bg) 2004-07-30

Family

ID=23063451

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108183A BG108183A (bg) 2001-03-22 2003-09-18 Селективни към топоизомераза i цитотоксични захаридни производни на индолопиролокарбазоли

Country Status (22)

Country Link
US (1) US6855698B2 (bg)
EP (1) EP1370673A4 (bg)
JP (1) JP2004534006A (bg)
KR (1) KR20030085035A (bg)
CN (1) CN1509335A (bg)
BG (1) BG108183A (bg)
BR (1) BR0208322A (bg)
CA (1) CA2441412A1 (bg)
CZ (1) CZ20032876A3 (bg)
EE (1) EE200300456A (bg)
HR (1) HRP20030761A2 (bg)
HU (1) HUP0400265A2 (bg)
IL (1) IL157909A0 (bg)
IS (1) IS6958A (bg)
MX (1) MXPA03008589A (bg)
NO (1) NO20034190L (bg)
PL (1) PL368942A1 (bg)
RU (1) RU2003131269A (bg)
SK (1) SK12022003A3 (bg)
WO (1) WO2002077255A1 (bg)
YU (1) YU74103A (bg)
ZA (1) ZA200307317B (bg)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4567143A (en) 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4785085A (en) 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
JP2766360B2 (ja) 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3924538A1 (de) 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
US5618809A (en) 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
IL97233A (en) 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them
US5478813A (en) 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
DE69331228T4 (de) 1992-09-21 2002-09-05 Kyowa Hakko Kogyo Co., Ltd. Heilmittel für thrombozytopenia
FR2696465B1 (fr) 1992-10-02 1994-12-23 Adir Nouveaux dérivés d'ellipticine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JP3603322B2 (ja) 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5468872A (en) 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
WO1995030682A1 (fr) 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
WO1996004293A1 (fr) 1994-08-02 1996-02-15 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazoles antitumoraux
US5475110A (en) 1994-10-14 1995-12-12 Cephalon, Inc. Fused Pyrrolocarbazoles
US5705511A (en) 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
AU6888196A (en) 1995-08-11 1997-03-12 Yale University Glycosylated indolocarbazole synthesis
JP2000516250A (ja) * 1996-08-22 2000-12-05 ブリストルーマイヤーズ スクイブ カンパニー インドロピロロカルバゾールの細胞毒性アミノ糖および関連する糖誘導体
CO4940430A1 (es) 1997-07-07 2000-07-24 Novartis Ag Compuestos policiclicos que contienen estaurosporina hidrogenada con propiedades farmacologicas convenientes y un efecto inhibidor sobre el crecimiento de las celulas tumorales
FR2801054B1 (fr) 1999-11-17 2003-06-13 Adir Nouveaux derives de 12,13-(pyranosyl)-indolo[2,3-a]pyrrolo [3,4-c]carbazole et 12,13-(pyranosyl)-furo[3,4-c]indolo [2,3-a]carbazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
IL157909A0 (en) 2004-03-28
CZ20032876A3 (en) 2004-03-17
ZA200307317B (en) 2004-12-20
SK12022003A3 (sk) 2004-05-04
IS6958A (is) 2003-09-16
PL368942A1 (en) 2005-04-04
EP1370673A4 (en) 2006-08-09
US6855698B2 (en) 2005-02-15
HUP0400265A2 (hu) 2004-08-30
MXPA03008589A (es) 2003-12-08
CA2441412A1 (en) 2002-10-03
CN1509335A (zh) 2004-06-30
HRP20030761A2 (en) 2004-04-30
BR0208322A (pt) 2004-10-13
EP1370673A1 (en) 2003-12-17
RU2003131269A (ru) 2005-05-10
YU74103A (sh) 2006-05-25
KR20030085035A (ko) 2003-11-01
JP2004534006A (ja) 2004-11-11
US20030083271A1 (en) 2003-05-01
NO20034190L (no) 2003-11-19
WO2002077255A1 (en) 2002-10-03
EE200300456A (et) 2004-02-16
NO20034190D0 (no) 2003-09-19

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