BG108020A - Методи за лечение или профилактика на кожни заболявания с приложение на cd2-свързващи агенти - Google Patents

Методи за лечение или профилактика на кожни заболявания с приложение на cd2-свързващи агенти Download PDF

Info

Publication number
BG108020A
BG108020A BG108020A BG10802003A BG108020A BG 108020 A BG108020 A BG 108020A BG 108020 A BG108020 A BG 108020A BG 10802003 A BG10802003 A BG 10802003A BG 108020 A BG108020 A BG 108020A
Authority
BG
Bulgaria
Prior art keywords
lfa
cells
lys
leu
antibody
Prior art date
Application number
BG108020A
Other languages
Bulgarian (bg)
English (en)
Inventor
Akshay K. Vaishnaw
Kevin D. Cooper
Daniel Shrager
Thomas S. Mccormick
Original Assignee
Biogen, Inc.
University Hospitals Of Cleveland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen, Inc., University Hospitals Of Cleveland filed Critical Biogen, Inc.
Publication of BG108020A publication Critical patent/BG108020A/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2824Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD58
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BG108020A 2001-02-01 2003-07-22 Методи за лечение или профилактика на кожни заболявания с приложение на cd2-свързващи агенти BG108020A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26596401P 2001-02-01 2001-02-01
PCT/US2002/002314 WO2002060480A1 (en) 2001-02-01 2002-01-25 Methods for treating or preventing skin disorders using cd2-binding agents

Publications (1)

Publication Number Publication Date
BG108020A true BG108020A (bg) 2004-03-31

Family

ID=23012611

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108020A BG108020A (bg) 2001-02-01 2003-07-22 Методи за лечение или профилактика на кожни заболявания с приложение на cd2-свързващи агенти

Country Status (22)

Country Link
US (3) US20040170635A1 (es)
EP (1) EP1409015A4 (es)
JP (1) JP2004527477A (es)
KR (1) KR20040043112A (es)
CN (1) CN1527723A (es)
AR (1) AR035079A1 (es)
BG (1) BG108020A (es)
BR (1) BR0206905A (es)
CA (1) CA2436411A1 (es)
CZ (1) CZ20032081A3 (es)
EA (1) EA200300849A1 (es)
EE (1) EE200300366A (es)
GE (1) GEP20063828B (es)
HU (1) HUP0303826A2 (es)
IS (1) IS6894A (es)
MX (1) MXPA03006919A (es)
NO (1) NO20033443L (es)
PL (1) PL368556A1 (es)
SK (1) SK9722003A3 (es)
WO (1) WO2002060480A1 (es)
YU (1) YU61203A (es)
ZA (1) ZA200305936B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764681B2 (en) 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
EP1109570B1 (en) * 1998-08-31 2005-10-19 Biogen, Inc. Modulation of memory effector t-cells with a cd2 binding agent
WO2002098370A2 (en) * 2001-03-02 2002-12-12 Medimmune, Inc. Methods of administering/dosing cd2 antagonists for the prevention and treatment of autoimmune disorders or inflammatory disorders
CA2454618C (en) 2001-07-24 2012-04-03 Biogen Idec Ma, Inc. Methods for treating or preventing sclerotic disorders using cd2-binding agents
DK1556020T3 (da) 2002-08-12 2009-06-22 Birkir Sveinsson Anvendelse af CGRP-antagonistforbindelser til behandling af psoriasis
GB0307864D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
US20070172478A1 (en) * 2004-02-06 2007-07-26 Astellas Us Llc Methods of treating skin disorders
BRPI0510691A (pt) * 2004-05-04 2007-12-26 Genaissance Pharmaceuticals marcadores de haplótipos e métodos de uso dos mesmos para determinar resposta ao tratamento
CA2565259A1 (en) 2004-05-07 2005-12-08 Astellas Us Llc Soluble lfa-3 polypeptide for treating viral disorders
US20060078580A1 (en) * 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
CN101113459A (zh) * 2007-07-16 2008-01-30 东莞太力生物工程有限公司 一种重组复制缺陷型病毒、含有该病毒的药物组合物及其应用
US9289469B2 (en) 2009-09-10 2016-03-22 Mayo Foundation For Medical Education And Research Depleting immunosuppressive monocytes within a mammal
US9266957B2 (en) 2009-11-10 2016-02-23 Mayo Foundation For Medical Education And Research Methods and materials for treating renal cell carcinoma and glioblastoma multiforme
WO2014025198A2 (ko) * 2012-08-09 2014-02-13 주식회사 한독 Lfa3 변이체 및 상기 변이체 또는 lfa3 cd2 결합영역과 이에 표적 특이적 폴리펩타이드가 연결된 융합단백질 및 그 용도
US9970936B2 (en) 2012-11-13 2018-05-15 Mayo Foundation For Medical Education And Research Methods and materials for assessing immune system profiles
WO2014182761A1 (en) 2013-05-09 2014-11-13 Mayo Foundation For Medical Education And Research Treating patients based on immune subtypes
US11433119B2 (en) 2016-11-18 2022-09-06 Nepsone Ehf Methods of treating inflammatory skin disorders
AU2019242451B2 (en) * 2018-03-29 2024-05-09 Pfizer Inc. LFA3 variants and compositions and uses thereof
WO2023224980A1 (en) * 2022-05-17 2023-11-23 The Uab Research Foundation Methods and compositions for treating or preventing inflammatory skin disorders
WO2024050455A2 (en) * 2022-08-31 2024-03-07 Heitmeyer Jamie Nicole Anti-rhd antibodies for treating inflammatory dermal condition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2112335T3 (es) * 1991-10-07 1998-04-01 Biogen Inc Procedimiento profilactico o terapeutico de enfermedades de la piel causadas por celulas que presentan antigenos por medio de inhibidores de la interaccion entre cd2 y lfa-3.
US6764681B2 (en) * 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US6162432A (en) * 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US5951983A (en) * 1993-03-05 1999-09-14 Universite Catholique De Louvain Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies
US5730979A (en) * 1993-03-05 1998-03-24 Universite Catholique Delouvain LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation
US5817311A (en) * 1993-03-05 1998-10-06 Universite Catholique De Louvain Methods of inhibiting T-cell medicated immune responses with LO-CD2a-specific antibodies
EP1109570B1 (en) * 1998-08-31 2005-10-19 Biogen, Inc. Modulation of memory effector t-cells with a cd2 binding agent

Also Published As

Publication number Publication date
WO2002060480A9 (en) 2004-05-27
YU61203A (sh) 2006-05-25
CA2436411A1 (en) 2002-08-08
NO20033443L (no) 2003-09-30
AR035079A1 (es) 2004-04-14
IS6894A (is) 2003-07-25
EP1409015A1 (en) 2004-04-21
EE200300366A (et) 2003-12-15
JP2004527477A (ja) 2004-09-09
EA200300849A1 (ru) 2004-02-26
SK9722003A3 (en) 2004-05-04
US20070031443A1 (en) 2007-02-08
ZA200305936B (en) 2005-01-26
CZ20032081A3 (cs) 2004-01-14
MXPA03006919A (es) 2004-06-02
US20040170635A1 (en) 2004-09-02
GEP20063828B (en) 2006-05-10
PL368556A1 (en) 2005-04-04
CN1527723A (zh) 2004-09-08
US20030185824A1 (en) 2003-10-02
WO2002060480A1 (en) 2002-08-08
HUP0303826A2 (hu) 2004-03-01
BR0206905A (pt) 2004-07-06
KR20040043112A (ko) 2004-05-22
NO20033443D0 (no) 2003-08-01
EP1409015A4 (en) 2006-04-12

Similar Documents

Publication Publication Date Title
US20070031443A1 (en) Methods for treating or preventing skin disorders using CD2-binding agents
KR102564248B1 (ko) 항-인간 vista 항체 및 이의 용도
RU2698975C2 (ru) Слитые иммуномодулирующие белки и способы их получения
CN111010875A (zh) 用于调节免疫应答的方法
WO2019051164A1 (en) ANTIBODIES AGAINST PROTEIN 1 OF PROGRAMMED CELL DEATH
US20030223989A1 (en) CD137 agonists to treat patients with IgE-mediated conditions
PL211786B1 (pl) Zastosowanie przeciwciała oraz polipeptydu
KR20060132541A (ko) 가용성 ctla4 분자를 사용한 심혈관 질환의 치료 방법
JPH09509826A (ja) 活性化cd4▲上+▼t細胞の表層上のレセプターに対するリガンド(act−4−l)
JP4712966B2 (ja) 単純ヘルペスウイルス侵入メディエーターのためのリガンドおよびその使用方法
JP2004503507A (ja) リンパ球シグナルのブロックおよびlfa−1媒介性接着のブロックによる細胞性免疫応答の調節方法
JP2021532119A (ja) 免疫関連疾患の予防または治療用組成物
CA2454618C (en) Methods for treating or preventing sclerotic disorders using cd2-binding agents
US7531168B2 (en) Method for downmodulating immune response in type I diabetes
US20070172478A1 (en) Methods of treating skin disorders
KR20220003562A (ko) 항-cd38 항체 및 제형
JP2023502876A (ja) がんの治療のためのher2/4-1bb二重特異性融合タンパク質
RU2826957C2 (ru) Антитела к cd38 и составы
AU2002237946A1 (en) Methods for treating or preventing skin disorders using CD2-binding agents
KR20070017320A (ko) 피부 질환을 치료하는 방법
WO2005115436A1 (en) Soluble lfa-3 polypeptide for treating viral disorders
KR20240137086A (ko) Pd-1 작용제인 세포예정사 단백질 1에 대한 항체
KR20230160366A (ko) 암 치료를 위한 her2/4-1bb 이중특이적 융합 단백질