BG103931A - Метод за получаване на лекарства, които включват нмg-соа-редуктазни инхибитори - Google Patents
Метод за получаване на лекарства, които включват нмg-соа-редуктазни инхибиториInfo
- Publication number
- BG103931A BG103931A BG103931A BG10393199A BG103931A BG 103931 A BG103931 A BG 103931A BG 103931 A BG103931 A BG 103931A BG 10393199 A BG10393199 A BG 10393199A BG 103931 A BG103931 A BG 103931A
- Authority
- BG
- Bulgaria
- Prior art keywords
- coa
- preparation
- reductase inhibitors
- medicaments including
- including hmg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Изобретението се отнася до метод за получаване налекарства, които включват HMG-CoA-редуктазни инхибитори под формата на техни соли. Съответните изходни активни вещества се превръщат с бази, които сав разтвор и съдържат алкални или алкалоземни йони, в активно съединение. Полученият разтвор, съдържащ активно съединение, се формулира в лекарствени препарати.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19725391A DE19725391A1 (de) | 1997-06-16 | 1997-06-16 | Verfahren zur Herstellung von Arzneimittel, enthaltend HMG-CoA-Reduktase-Inhibitoren |
PCT/EP1998/003294 WO1998057917A1 (de) | 1997-06-16 | 1998-06-03 | VERFAHREN ZUR HERSTELLUNG VON ARZNEIMITTELN, ENTHALTEND HMG-CoA- REDUKTASEINHIBITOREN |
Publications (1)
Publication Number | Publication Date |
---|---|
BG103931A true BG103931A (bg) | 2000-07-31 |
Family
ID=7832616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG103931A BG103931A (bg) | 1997-06-16 | 1999-11-30 | Метод за получаване на лекарства, които включват нмg-соа-редуктазни инхибитори |
Country Status (23)
Country | Link |
---|---|
US (2) | US20020146454A1 (bg) |
EP (1) | EP0991616B1 (bg) |
JP (1) | JP2002504126A (bg) |
KR (1) | KR20010013792A (bg) |
CN (1) | CN1260774A (bg) |
AR (1) | AR012963A1 (bg) |
AT (1) | ATE240925T1 (bg) |
AU (1) | AU734787B2 (bg) |
BG (1) | BG103931A (bg) |
BR (1) | BR9810129A (bg) |
CA (1) | CA2294724A1 (bg) |
DE (2) | DE19725391A1 (bg) |
ES (1) | ES2198728T3 (bg) |
HU (1) | HUP0002720A3 (bg) |
ID (1) | ID23179A (bg) |
IL (1) | IL132987A0 (bg) |
NO (1) | NO996183D0 (bg) |
NZ (1) | NZ501760A (bg) |
PL (1) | PL337343A1 (bg) |
SK (1) | SK171199A3 (bg) |
TR (1) | TR199902871T2 (bg) |
WO (1) | WO1998057917A1 (bg) |
ZA (1) | ZA985179B (bg) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
DK2382970T3 (da) * | 2000-04-10 | 2013-03-25 | Teva Pharma | Stabile farmaceutiske sammensætninger, der indeholder 7-substitueret-3,5-dihydroxyheptansyrer eller 7-substitueret-3,5-dihydroxyheptensyrer |
EP1810667A1 (en) * | 2006-01-20 | 2007-07-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising amorphous atorvastatin |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU9203780D0 (en) * | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
DE69324504T2 (de) * | 1993-01-19 | 1999-08-26 | Warner Lambert Co | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren |
-
1997
- 1997-06-16 DE DE19725391A patent/DE19725391A1/de not_active Withdrawn
-
1998
- 1998-06-03 IL IL13298798A patent/IL132987A0/xx unknown
- 1998-06-03 CN CN98806270A patent/CN1260774A/zh active Pending
- 1998-06-03 HU HU0002720A patent/HUP0002720A3/hu unknown
- 1998-06-03 SK SK1711-99A patent/SK171199A3/sk unknown
- 1998-06-03 BR BR9810129-3A patent/BR9810129A/pt not_active IP Right Cessation
- 1998-06-03 KR KR1019997011810A patent/KR20010013792A/ko not_active Application Discontinuation
- 1998-06-03 EP EP98933586A patent/EP0991616B1/de not_active Expired - Lifetime
- 1998-06-03 AU AU83353/98A patent/AU734787B2/en not_active Ceased
- 1998-06-03 ES ES98933586T patent/ES2198728T3/es not_active Expired - Lifetime
- 1998-06-03 ID IDW991494A patent/ID23179A/id unknown
- 1998-06-03 AT AT98933586T patent/ATE240925T1/de not_active IP Right Cessation
- 1998-06-03 TR TR1999/02871T patent/TR199902871T2/xx unknown
- 1998-06-03 NZ NZ501760A patent/NZ501760A/en unknown
- 1998-06-03 US US09/446,342 patent/US20020146454A1/en not_active Abandoned
- 1998-06-03 WO PCT/EP1998/003294 patent/WO1998057917A1/de not_active Application Discontinuation
- 1998-06-03 CA CA002294724A patent/CA2294724A1/en not_active Abandoned
- 1998-06-03 JP JP50365499A patent/JP2002504126A/ja not_active Ceased
- 1998-06-03 PL PL98337343A patent/PL337343A1/xx unknown
- 1998-06-03 DE DE59808476T patent/DE59808476D1/de not_active Expired - Fee Related
- 1998-06-10 AR ARP980102754A patent/AR012963A1/es not_active Application Discontinuation
- 1998-06-15 ZA ZA985179A patent/ZA985179B/xx unknown
-
1999
- 1999-11-30 BG BG103931A patent/BG103931A/bg unknown
- 1999-12-14 NO NO996183A patent/NO996183D0/no not_active Application Discontinuation
-
2003
- 2003-06-05 US US10/456,222 patent/US20030203964A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TR199902871T2 (xx) | 2000-02-21 |
CN1260774A (zh) | 2000-07-19 |
DE59808476D1 (de) | 2003-06-26 |
NO996183L (no) | 1999-12-14 |
ID23179A (id) | 2000-03-23 |
AR012963A1 (es) | 2000-11-22 |
EP0991616A1 (de) | 2000-04-12 |
EP0991616B1 (de) | 2003-05-21 |
PL337343A1 (en) | 2000-08-14 |
US20030203964A1 (en) | 2003-10-30 |
BR9810129A (pt) | 2000-08-08 |
DE19725391A1 (de) | 1998-12-17 |
CA2294724A1 (en) | 1998-12-23 |
AU8335398A (en) | 1999-01-04 |
US20020146454A1 (en) | 2002-10-10 |
AU734787B2 (en) | 2001-06-21 |
SK171199A3 (en) | 2000-07-11 |
ES2198728T3 (es) | 2004-02-01 |
NZ501760A (en) | 2001-05-25 |
ATE240925T1 (de) | 2003-06-15 |
KR20010013792A (ko) | 2001-02-26 |
NO996183D0 (no) | 1999-12-14 |
WO1998057917A1 (de) | 1998-12-23 |
HUP0002720A3 (en) | 2001-12-28 |
HUP0002720A2 (hu) | 2000-12-28 |
IL132987A0 (en) | 2001-03-19 |
JP2002504126A (ja) | 2002-02-05 |
ZA985179B (en) | 1999-01-08 |
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