BG103115A - Steroids as neurochemical strimulators of the vomeronasal organ for easing the syptoms of the premenstrual syndrom and anxiety - Google Patents

Steroids as neurochemical strimulators of the vomeronasal organ for easing the syptoms of the premenstrual syndrom and anxiety

Info

Publication number
BG103115A
BG103115A BG103115A BG10311599A BG103115A BG 103115 A BG103115 A BG 103115A BG 103115 A BG103115 A BG 103115A BG 10311599 A BG10311599 A BG 10311599A BG 103115 A BG103115 A BG 103115A
Authority
BG
Bulgaria
Prior art keywords
steroids
strimulators
syptoms
syndrom
neurochemical
Prior art date
Application number
BG103115A
Other languages
Bulgarian (bg)
English (en)
Inventor
Clive Jennings-White
David Berliner
Nathan Adams
Luis Bloch-Monti
Original Assignee
Pherin Pharmaceuticals, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/686,092 external-priority patent/US6057439A/en
Application filed by Pherin Pharmaceuticals, Inc filed Critical Pherin Pharmaceuticals, Inc
Publication of BG103115A publication Critical patent/BG103115A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/002—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 13 (17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
BG103115A 1996-07-23 1999-01-25 Steroids as neurochemical strimulators of the vomeronasal organ for easing the syptoms of the premenstrual syndrom and anxiety BG103115A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/686,092 US6057439A (en) 1994-08-04 1996-07-23 Steroids as neurochemical stimulators of the VNO to alleviate symptoms of PMS and anxiety
US72586296A 1996-10-04 1996-10-04
PCT/US1997/013035 WO1998003207A1 (en) 1996-07-23 1997-07-23 Steroids as neurochemical stimulators of the vno to alleviate symptoms of pms and anxiety

Publications (1)

Publication Number Publication Date
BG103115A true BG103115A (en) 1999-09-30

Family

ID=27103741

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103115A BG103115A (en) 1996-07-23 1999-01-25 Steroids as neurochemical strimulators of the vomeronasal organ for easing the syptoms of the premenstrual syndrom and anxiety

Country Status (15)

Country Link
EP (1) EP0914165B1 (de)
JP (1) JP4450435B2 (de)
KR (1) KR20000067970A (de)
CN (1) CN1226837A (de)
AT (1) ATE342721T1 (de)
AU (1) AU726625B2 (de)
BG (1) BG103115A (de)
BR (1) BR9711812A (de)
CA (1) CA2260253A1 (de)
DE (1) DE69736833T2 (de)
ES (1) ES2273374T3 (de)
NO (1) NO990305L (de)
NZ (1) NZ333671A (de)
PL (1) PL331357A1 (de)
WO (1) WO1998003207A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922699A (en) * 1996-06-07 1999-07-13 Pherin Corporation 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function
FR2791572A1 (fr) * 1999-03-31 2000-10-06 Adir Utilisation d'hormones sexuelles pour l'obtention d'une composition pharmaceutique nasale utile pour le traitement des saignements uterins indesirables
WO2001041732A1 (en) * 1999-12-06 2001-06-14 Gore Stanley L Compositions and methods for intranasal delivery of active agents to the brain
US6555531B1 (en) * 1999-12-30 2003-04-29 Pherin Pharmaceuticals, Inc. Weight promoting composition, method, and product
US8309539B2 (en) 2005-09-09 2012-11-13 Pherin Pharmaceuticals, Inc. Acute treatment of social phobia
CN102056484B (zh) * 2008-04-09 2014-10-29 费林药业公司 用于热潮红的类固醇治疗
JP6283689B2 (ja) * 2012-12-28 2018-02-21 フィーリン・ファーマシューティカルズ・インコーポレイテッドＰｈｅｒｉｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． うつ病性障害の処置のためのプレグナ‐４‐エン‐２０‐イン‐３‐オンの使用
US11419881B2 (en) * 2019-04-15 2022-08-23 Pherin Pharmaceuticals, Inc. Treatment of migraine
WO2021080880A1 (en) * 2019-10-25 2021-04-29 Covey Douglas Nmdar inhibiting agents and gabaar potentiating agents and uses thereof
CN112608358A (zh) * 2020-12-29 2021-04-06 北京大学 一种促进花粉萌发的化合物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208227A (en) * 1987-08-25 1993-05-04 University Of Southern California Method, compositions, and compounds for modulating brain excitability
US5969168A (en) * 1991-01-07 1999-10-19 Pherin Corporation Androstanes for inducing hypothalamic effects
JPH09501408A (ja) * 1993-06-15 1997-02-10 フェリン コーポレイション ヒト視床下部機能における変化の神経化学的イニシエータとしてのエストレンステロイドおよび関連する薬理組成物並びに方法
EP0711169B1 (de) * 1993-06-15 2003-12-10 Pherin Corporation Androstansteroide als neurochemische initiatoren einer veränderung der hypothalamusfunktion beim menschen und verwandte pharmazeutische präparate und verfahren
US5792757A (en) * 1994-08-04 1998-08-11 Pherin Pharmaceuticals 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
US5563131A (en) * 1994-08-04 1996-10-08 Pherin Corporation Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
HUT76856A (en) * 1994-09-29 1997-12-29 Pherin Corp Novel estrenes for inducing hypothalamic effects
US5922699A (en) * 1996-06-07 1999-07-13 Pherin Corporation 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function

Also Published As

Publication number Publication date
EP0914165B1 (de) 2006-10-18
AU3963797A (en) 1998-02-10
AU726625B2 (en) 2000-11-16
EP0914165A1 (de) 1999-05-12
CN1226837A (zh) 1999-08-25
CA2260253A1 (en) 1998-01-29
EP0914165A4 (de) 2004-01-21
NZ333671A (en) 2000-07-28
JP4450435B2 (ja) 2010-04-14
ES2273374T3 (es) 2007-05-01
KR20000067970A (ko) 2000-11-25
NO990305L (no) 1999-03-22
DE69736833T2 (de) 2007-05-24
JP2000513000A (ja) 2000-10-03
NO990305D0 (no) 1999-01-22
WO1998003207A1 (en) 1998-01-29
DE69736833D1 (de) 2006-11-30
BR9711812A (pt) 1999-08-24
PL331357A1 (en) 1999-07-05
ATE342721T1 (de) 2006-11-15

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