BG100166A - Използване на природни продукти и техните съответни синтетични производни за лечение на сърдечно-съдови заболявания - Google Patents

Използване на природни продукти и техните съответни синтетични производни за лечение на сърдечно-съдови заболявания

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Publication number
BG100166A
BG100166A BG100166A BG10016695A BG100166A BG 100166 A BG100166 A BG 100166A BG 100166 A BG100166 A BG 100166A BG 10016695 A BG10016695 A BG 10016695A BG 100166 A BG100166 A BG 100166A
Authority
BG
Bulgaria
Prior art keywords
optionally substituted
alkynyl
alkenyl
alkyl
hydrogen
Prior art date
Application number
BG100166A
Other languages
English (en)
Inventor
Basil Roufogalis
Colin Duke
Qian Li
Original Assignee
The University Of Sydney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Sydney filed Critical The University Of Sydney
Publication of BG100166A publication Critical patent/BG100166A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C07C39/16—Bis-(hydroxyphenyl) alkanes; Tris-(hydroxyphenyl)alkanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with at least one hydroxy group on a condensed ring system containing two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
    • C07C39/15—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings with all hydroxy groups on non-condensed rings, e.g. phenylphenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретението се отнася до използване на нови съединения и 8-лавандулилфлавон фармацевтични форми. Те имат формула вкоято аr е ароматна циклична система, съдържаща едно или повече по желание заместени фенилови ядра,по желание свързани помежду си или съединени с едно или повече други по желание заместени фенилови ядра, или едно или повече 5или 6-членни по желаниезаместени хетероциклени ядра, в които хетероатомъте кислород и цикличната система съдържа 1-4 фенилови цикъла, но аr може да бъде свързан към друг аrчрез група х, в която аr е независимо избран, а хпо желание е субституиран с1-20 алкилен, с1-20 алкенилен или с2-20 алкенилен; r е водород, с1-20 алкенил; с2-20 алкинил, с2-20 алканоил, с2-20 алкиноил, всеки от които може да бъде по желание заместен; r1 е независимо избран и е водород, по желание субституиран с1-12 алкил, с2-12 алкенил, с2-12 алкинил, -сооr' nr'r', халоген, -оr -соr', -соnr'r'=о2-sr,-sо3r, -sо2nr'r', -sоr, -sоr', -sо2r', -nо2,-сn, гликозид, силил, като r' е независимо водород,алкил, алкенил или алкинил, всеки по желание субституиран, а две групи r1 могат да бъдат свързани, като евентуалните им заместители са един или повече независимо избрани от с1-10 алкил, с2-10 алкенил, с2-10 алкинил, -сооr'', -nr''r'', халоген, оr'',-соr'', -соnr''r'', -sr'', =о, -sо3r'', -sо2nr''r'', -sоr'', -sо2, -nо2, -сn, като r'' е независимоводород, алкил, алкенил, или алкинил; n има стойност 1, 2 или 3, а м е 1, 2, 3 или 4. Изобретениетосе отнася и до техни фармацевтично прие
BG100166A 1993-06-03 1995-11-24 Използване на природни продукти и техните съответни синтетични производни за лечение на сърдечно-съдови заболявания BG100166A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL918193 1993-06-03
PCT/AU1994/000297 WO1994028886A1 (en) 1993-06-03 1994-06-03 Use of natural products and related synthetic compounds for the treatment of cardiovascular disease

Publications (1)

Publication Number Publication Date
BG100166A true BG100166A (bg) 1996-11-29

Family

ID=3776946

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100166A BG100166A (bg) 1993-06-03 1995-11-24 Използване на природни продукти и техните съответни синтетични производни за лечение на сърдечно-съдови заболявания

Country Status (16)

Country Link
US (2) US5741821A (bg)
EP (1) EP0703780A4 (bg)
JP (1) JPH09502163A (bg)
KR (1) KR960702749A (bg)
CN (1) CN1124922A (bg)
BG (1) BG100166A (bg)
BR (1) BR9406747A (bg)
CA (1) CA2164317A1 (bg)
CZ (1) CZ318795A3 (bg)
FI (1) FI955786A (bg)
HU (1) HUT74174A (bg)
NO (1) NO954479L (bg)
PL (1) PL311810A1 (bg)
SI (1) SI9420037A (bg)
SK (1) SK147995A3 (bg)
WO (1) WO1994028886A1 (bg)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7582298A (en) 1997-05-19 1998-12-11 Johns Hopkins University School Of Medicine, The Tissue specific prodrug
US6545131B1 (en) 1997-05-19 2003-04-08 The Johns Hopkins University Tissue specific prodrug
US6504014B1 (en) 1997-05-19 2003-01-07 The John Hopkins University Tissue specific prodrug
US6538022B1 (en) * 1997-09-24 2003-03-25 Orion Corporation Compounds for deactivating phospholamban function on Ca-ATPase (phopholamban inhibitors)
RU2137472C1 (ru) * 1998-10-12 1999-09-20 Тихоокеанский институт биоорганической химии Дальневосточного отделения РАН Лекарственный препарат "гистохром" для лечения острого инфаркта миокарда и ишемической болезни сердца
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
EP1171628A2 (en) * 1999-04-15 2002-01-16 Devgen NV Compound screening methods
US7053042B1 (en) 1999-07-29 2006-05-30 Samuel Denmeade Activation of peptide prodrugs by hK2
AU2001296402A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
AU2002213429A1 (en) * 2000-09-28 2002-04-08 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
EP1206934A1 (en) * 2000-11-15 2002-05-22 B. Braun Melsungen Ag Blockade of sodium channels by phenol derivatives
KR100704299B1 (ko) * 2005-11-17 2007-04-09 한국생명공학연구원 신규한 퀴놀린계 화합물, 및 지네 추출물 또는 이로부터 분리된 화합물을 포함하는 심장순환계 질환의 예방 및 치료용 조성물
US9024273B2 (en) * 2010-04-20 2015-05-05 Varian Semiconductor Equipment Associates, Inc. Method to generate molecular ions from ions with a smaller atomic mass

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2321620A (en) * 1940-10-10 1943-06-15 Du Pont Phenolic compounds
DE3527862A1 (de) * 1985-08-02 1987-02-05 Bayer Ag Verfahren zur herstellung von bis-hydroxyphenyl-n-alkanen, neue bis-hydroxyphenyl-n-alkane und neue alkandione

Also Published As

Publication number Publication date
CZ318795A3 (en) 1996-06-12
FI955786A (fi) 1996-01-29
NO954479L (no) 1996-02-02
PL311810A1 (en) 1996-03-18
WO1994028886A1 (en) 1994-12-22
US5859067A (en) 1999-01-12
NO954479D0 (no) 1995-11-08
FI955786A0 (fi) 1995-12-01
CA2164317A1 (en) 1994-12-22
EP0703780A4 (en) 1998-01-07
HUT74174A (en) 1996-11-28
EP0703780A1 (en) 1996-04-03
BR9406747A (pt) 1996-04-02
CN1124922A (zh) 1996-06-19
KR960702749A (ko) 1996-05-23
US5741821A (en) 1998-04-21
JPH09502163A (ja) 1997-03-04
SI9420037A (en) 1996-08-31
SK147995A3 (en) 1997-04-09
HU9503441D0 (en) 1996-01-29

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