BG100068A - Method of detecting the presence of and converting of a polypeptide - Google Patents
Method of detecting the presence of and converting of a polypeptideInfo
- Publication number
- BG100068A BG100068A BG100068A BG10006895A BG100068A BG 100068 A BG100068 A BG 100068A BG 100068 A BG100068 A BG 100068A BG 10006895 A BG10006895 A BG 10006895A BG 100068 A BG100068 A BG 100068A
- Authority
- BG
- Bulgaria
- Prior art keywords
- growth hormone
- polypeptide
- converting
- detecting
- mercaptan
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 abstract 2
- 108010051696 Growth Hormone Proteins 0.000 abstract 2
- 239000000122 growth hormone Substances 0.000 abstract 2
- -1 mercaptan compound Chemical class 0.000 abstract 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
- 235000011130 ammonium sulphate Nutrition 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 239000003111 growth hormone derivative Substances 0.000 abstract 1
- 229940121366 growth hormone derivative Drugs 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000012510 peptide mapping method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/61—Growth hormones [GH] (Somatotropin)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK93445A DK44593D0 (da) | 1993-04-20 | 1993-04-20 | Fremgangsmaade til fremstilling af et polypeptid |
| PCT/DK1994/000157 WO1994024157A1 (fr) | 1993-04-20 | 1994-04-19 | Procede de detection de la presence d'un polypeptide et de conversion de ce dernier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG100068A true BG100068A (en) | 1996-12-31 |
Family
ID=8093625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG100068A BG100068A (en) | 1993-04-20 | 1995-10-17 | Method of detecting the presence of and converting of a polypeptide |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0695310A1 (fr) |
| JP (1) | JPH08508735A (fr) |
| KR (1) | KR960701891A (fr) |
| AU (1) | AU6535594A (fr) |
| BG (1) | BG100068A (fr) |
| CA (1) | CA2160663A1 (fr) |
| CZ (1) | CZ272895A3 (fr) |
| DK (1) | DK44593D0 (fr) |
| FI (1) | FI955000A (fr) |
| HU (1) | HUT73320A (fr) |
| IL (1) | IL109347A0 (fr) |
| NO (1) | NO954181D0 (fr) |
| PL (1) | PL311198A1 (fr) |
| WO (1) | WO1994024157A1 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9802454D0 (sv) | 1998-07-08 | 1998-07-08 | Pharmacia & Upjohn Ab | Production of peptides |
| US20040048315A1 (en) * | 2002-08-28 | 2004-03-11 | Pharmacia Corporation | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| ZA200501841B (en) * | 2002-08-28 | 2007-06-27 | Pharmacia Corp | Method for the preparation of growth hormone and antagonist thereof having lower levels of isoform impurities thereof |
| ATE453662T1 (de) * | 2002-09-20 | 2010-01-15 | Pharmacia Corp | Verfahren zur verringerung der aggregatmengen des pegylierten proteins |
| ZA200502320B (en) * | 2002-09-20 | 2006-10-25 | Pharmacia Corp | Process for decreasing aggregate levels of pegylated protein |
| ATE463503T1 (de) | 2004-12-29 | 2010-04-15 | Novo Nordisk Healthcare Ag | Verfahren zur verhinderung der bildung von trisulfidderivaten von polypeptiden |
| WO2011041721A1 (fr) | 2009-10-02 | 2011-04-07 | Biogen Idec Ma Inc. | Procédés permettant d'empêcher et d'éliminer des liaisons trisulfure |
| WO2012158551A1 (fr) | 2011-05-13 | 2012-11-22 | Biogen Idec Ma Inc. | Procédés pour prévenir et éliminer des liaisons trisulfure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4985544A (en) * | 1987-08-04 | 1991-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for renaturing fish growth hormone |
| US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
| DE69129747T2 (de) * | 1990-09-05 | 1998-11-12 | Southern Cross Biotech Pty. Ltd., Toorak, Victoria | In lösung bringen von proteinen in aktiver form |
| US5151501A (en) * | 1991-12-20 | 1992-09-29 | American Cyanamid Company | Method for solubilization and naturation of somatotropins utilizing sulfolane |
-
1993
- 1993-04-20 DK DK93445A patent/DK44593D0/da not_active Application Discontinuation
-
1994
- 1994-04-19 WO PCT/DK1994/000157 patent/WO1994024157A1/fr not_active Application Discontinuation
- 1994-04-19 HU HU9503020A patent/HUT73320A/hu unknown
- 1994-04-19 AU AU65355/94A patent/AU6535594A/en not_active Abandoned
- 1994-04-19 JP JP6522643A patent/JPH08508735A/ja active Pending
- 1994-04-19 PL PL94311198A patent/PL311198A1/xx unknown
- 1994-04-19 CA CA002160663A patent/CA2160663A1/fr not_active Abandoned
- 1994-04-19 KR KR1019950704477A patent/KR960701891A/ko not_active Application Discontinuation
- 1994-04-19 IL IL10934794A patent/IL109347A0/xx unknown
- 1994-04-19 CZ CZ952728A patent/CZ272895A3/cs unknown
- 1994-04-19 EP EP94913048A patent/EP0695310A1/fr not_active Withdrawn
-
1995
- 1995-10-17 BG BG100068A patent/BG100068A/xx unknown
- 1995-10-19 NO NO954181A patent/NO954181D0/no unknown
- 1995-10-19 FI FI955000A patent/FI955000A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9503020D0 (en) | 1995-12-28 |
| DK44593D0 (da) | 1993-04-20 |
| CZ272895A3 (en) | 1996-03-13 |
| KR960701891A (ko) | 1996-03-28 |
| AU6535594A (en) | 1994-11-08 |
| CA2160663A1 (fr) | 1994-10-27 |
| EP0695310A1 (fr) | 1996-02-07 |
| JPH08508735A (ja) | 1996-09-17 |
| HUT73320A (en) | 1996-07-29 |
| NO954181L (no) | 1995-10-19 |
| IL109347A0 (en) | 1994-07-31 |
| FI955000A0 (fi) | 1995-10-19 |
| FI955000A (fi) | 1995-10-19 |
| PL311198A1 (en) | 1996-02-05 |
| WO1994024157A1 (fr) | 1994-10-27 |
| NO954181D0 (no) | 1995-10-19 |
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