BE905704A - Procede de preparation de (2s,3s) - 3 - acetoxy - 5 - (n,n' - dimethylaminoethyl) - 2 - (4 - methoxyphenyl) - 2,3 - dihydro -1,5 - benzothiazepin - 4(5h) - one. - Google Patents
Procede de preparation de (2s,3s) - 3 - acetoxy - 5 - (n,n' - dimethylaminoethyl) - 2 - (4 - methoxyphenyl) - 2,3 - dihydro -1,5 - benzothiazepin - 4(5h) - one.Info
- Publication number
- BE905704A BE905704A BE0/217372A BE217372A BE905704A BE 905704 A BE905704 A BE 905704A BE 0/217372 A BE0/217372 A BE 0/217372A BE 217372 A BE217372 A BE 217372A BE 905704 A BE905704 A BE 905704A
- Authority
- BE
- Belgium
- Prior art keywords
- benzothiazepin
- dihydro
- acetoxy
- methoxyphenyl
- dimethylaminoethyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000008569 process Effects 0.000 title abstract 2
- 230000029936 alkylation Effects 0.000 abstract 3
- 238000005804 alkylation reaction Methods 0.000 abstract 3
- 230000021736 acetylation Effects 0.000 abstract 2
- 238000006640 acetylation reaction Methods 0.000 abstract 2
- -1 2-dimethylaminoethanol hydrochloride mesylate Chemical compound 0.000 abstract 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 abstract 1
- HETCEOQFVDFGSY-UHFFFAOYSA-N Isopropenyl acetate Chemical compound CC(=C)OC(C)=O HETCEOQFVDFGSY-UHFFFAOYSA-N 0.000 abstract 1
- WKLRIRQZTCFCSE-UHFFFAOYSA-N [2-(4-methoxyphenyl)-4-oxo-3,5-dihydro-2h-1,5-benzothiazepin-3-yl] acetate Chemical compound C1=CC(OC)=CC=C1C1C(OC(C)=O)C(=O)NC2=CC=CC=C2S1 WKLRIRQZTCFCSE-UHFFFAOYSA-N 0.000 abstract 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU854264A HU195795B (en) | 1985-11-06 | 1985-11-06 | Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE905704A true BE905704A (fr) | 1987-03-02 |
Family
ID=10967486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/217372A BE905704A (fr) | 1985-11-06 | 1986-11-05 | Procede de preparation de (2s,3s) - 3 - acetoxy - 5 - (n,n' - dimethylaminoethyl) - 2 - (4 - methoxyphenyl) - 2,3 - dihydro -1,5 - benzothiazepin - 4(5h) - one. |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS62108872A (enrdf_load_html_response) |
| AT (1) | AT393837B (enrdf_load_html_response) |
| BE (1) | BE905704A (enrdf_load_html_response) |
| CA (1) | CA1309714C (enrdf_load_html_response) |
| ES (1) | ES2001146A6 (enrdf_load_html_response) |
| HU (1) | HU195795B (enrdf_load_html_response) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR880100516A (en) * | 1987-08-21 | 1989-05-25 | Tanabe Seiyaku Co | Preparation method for 1,5-binzodiapezine derivatives |
| EP0355395A1 (en) * | 1988-07-26 | 1990-02-28 | ZAMBON GROUP S.p.A. | Process for the preparation of intermediates for the synthesis of diltiazem |
-
1985
- 1985-11-06 HU HU854264A patent/HU195795B/hu not_active IP Right Cessation
-
1986
- 1986-11-05 JP JP61263630A patent/JPS62108872A/ja active Granted
- 1986-11-05 BE BE0/217372A patent/BE905704A/fr not_active IP Right Cessation
- 1986-11-05 ES ES8602911A patent/ES2001146A6/es not_active Expired
- 1986-11-05 AT AT0294786A patent/AT393837B/de not_active IP Right Cessation
- 1986-11-05 CA CA000522187A patent/CA1309714C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR880100516A (en) * | 1987-08-21 | 1989-05-25 | Tanabe Seiyaku Co | Preparation method for 1,5-binzodiapezine derivatives |
| EP0355395A1 (en) * | 1988-07-26 | 1990-02-28 | ZAMBON GROUP S.p.A. | Process for the preparation of intermediates for the synthesis of diltiazem |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0354939B2 (enrdf_load_html_response) | 1991-08-21 |
| CA1309714C (en) | 1992-11-03 |
| HUT42767A (en) | 1987-08-28 |
| ES2001146A6 (es) | 1988-04-16 |
| AT393837B (de) | 1991-12-27 |
| ATA294786A (de) | 1991-06-15 |
| HU195795B (en) | 1988-07-28 |
| JPS62108872A (ja) | 1987-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Effective date: 20051130 |