BE905704A - PROCESS FOR THE PREPARATION OF (2S, 3S) - 3 - ACETOXY - 5 - (N, N '- DIMETHYLAMINOETHYL) - 2 - (4 - METHOXYPHENYL) - 2,3 - DIHYDRO -1,5 - BENZOTHIAZEPIN - 4 (5H) - ONE. - Google Patents

PROCESS FOR THE PREPARATION OF (2S, 3S) - 3 - ACETOXY - 5 - (N, N '- DIMETHYLAMINOETHYL) - 2 - (4 - METHOXYPHENYL) - 2,3 - DIHYDRO -1,5 - BENZOTHIAZEPIN - 4 (5H) - ONE.

Info

Publication number
BE905704A
BE905704A BE0/217372A BE217372A BE905704A BE 905704 A BE905704 A BE 905704A BE 0/217372 A BE0/217372 A BE 0/217372A BE 217372 A BE217372 A BE 217372A BE 905704 A BE905704 A BE 905704A
Authority
BE
Belgium
Prior art keywords
benzothiazepin
dihydro
acetoxy
methoxyphenyl
dimethylaminoethyl
Prior art date
Application number
BE0/217372A
Other languages
French (fr)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of BE905704A publication Critical patent/BE905704A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de préparation de la (2S,3S) -3-acétoxy-5- (N,N-diméthylaminoéthyl) -2- (4-méthoxy-phényl) -2,3-dihydro-1,5-benzothiazépin-4 (5H) -one de formule (I) par a) alkylation en acétylation de la (2S,3S) -3-hydroxy-2- (4-méthoxyphényl) 2-3-dihydro-1,5-benzothiazépin-4(5H)-one; b) alkylation de la 3-acétoxy-2- (4-méthoxyphényl) -2,3-dihydro-1,5-benzothiazépin-4(5H)-one caractérisé en ce qu'on effectue l'alkylation avec du 2-diméthylaminoéthanol mésylate hydrochlorure et/ou effectue l'acétylation avec de l'acétate d'isopropényle,Process for the preparation of (2S, 3S) -3-acetoxy-5- (N, N-dimethylaminoethyl) -2- (4-methoxy-phenyl) -2,3-dihydro-1,5-benzothiazepin-4 (5H ) -one of formula (I) by a) acetylation alkylation of (2S, 3S) -3-hydroxy-2- (4-methoxyphenyl) 2-3-dihydro-1,5-benzothiazepin-4 (5H) - one; b) alkylation of 3-acetoxy-2- (4-methoxyphenyl) -2,3-dihydro-1,5-benzothiazepin-4 (5H) -one characterized in that the alkylation is carried out with 2-dimethylaminoethanol hydrochloride mesylate and / or performs acetylation with isopropenyl acetate,

BE0/217372A 1985-11-06 1986-11-05 PROCESS FOR THE PREPARATION OF (2S, 3S) - 3 - ACETOXY - 5 - (N, N '- DIMETHYLAMINOETHYL) - 2 - (4 - METHOXYPHENYL) - 2,3 - DIHYDRO -1,5 - BENZOTHIAZEPIN - 4 (5H) - ONE. BE905704A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU854264A HU195795B (en) 1985-11-06 1985-11-06 Process for preparing (2s,3s)-3-acetoxy-5-(n,n-dimethyl-amino-ethyl)-2-(h-methoxy-phenyl)-2,3-dihydro-1,5-benzothiazepin-h(5h)-one

Publications (1)

Publication Number Publication Date
BE905704A true BE905704A (en) 1987-03-02

Family

ID=10967486

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217372A BE905704A (en) 1985-11-06 1986-11-05 PROCESS FOR THE PREPARATION OF (2S, 3S) - 3 - ACETOXY - 5 - (N, N '- DIMETHYLAMINOETHYL) - 2 - (4 - METHOXYPHENYL) - 2,3 - DIHYDRO -1,5 - BENZOTHIAZEPIN - 4 (5H) - ONE.

Country Status (6)

Country Link
JP (1) JPS62108872A (en)
AT (1) AT393837B (en)
BE (1) BE905704A (en)
CA (1) CA1309714C (en)
ES (1) ES2001146A6 (en)
HU (1) HU195795B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR880100516A (en) * 1987-08-21 1989-05-25 Tanabe Seiyaku Co Preparation method for 1,5-binzodiapezine derivatives
EP0355395A1 (en) * 1988-07-26 1990-02-28 ZAMBON GROUP S.p.A. Process for the preparation of intermediates for the synthesis of diltiazem

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR880100516A (en) * 1987-08-21 1989-05-25 Tanabe Seiyaku Co Preparation method for 1,5-binzodiapezine derivatives
EP0355395A1 (en) * 1988-07-26 1990-02-28 ZAMBON GROUP S.p.A. Process for the preparation of intermediates for the synthesis of diltiazem

Also Published As

Publication number Publication date
CA1309714C (en) 1992-11-03
JPS62108872A (en) 1987-05-20
AT393837B (en) 1991-12-27
JPH0354939B2 (en) 1991-08-21
HUT42767A (en) 1987-08-28
HU195795B (en) 1988-07-28
ES2001146A6 (en) 1988-04-16
ATA294786A (en) 1991-06-15

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Effective date: 20051130