BE902474A - Procede pour la preparation de peptides. - Google Patents

Procede pour la preparation de peptides.

Info

Publication number
BE902474A
BE902474A BE0/215050A BE215050A BE902474A BE 902474 A BE902474 A BE 902474A BE 0/215050 A BE0/215050 A BE 0/215050A BE 215050 A BE215050 A BE 215050A BE 902474 A BE902474 A BE 902474A
Authority
BE
Belgium
Prior art keywords
preparation
peptides
hydrolastic
aspartyl
phenylalanine
Prior art date
Application number
BE0/215050A
Other languages
English (en)
Inventor
S Cambiaghi
F Dallatomasina
P Giardino
E Murador
G Spreafico
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE902474A publication Critical patent/BE902474A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)

Abstract

Procédé pour la préparation de peptides qui consiste à préparer un ester alkylique inférieur (C1-C4) de L-alpha-aspartyl-L-phénylalanine par une hydrolyse enzymatique effectuée avec des enzymes hydrolasiques d'un dérivé N-acyl- convenable. L'invention se rapporte aussi à la préparation d'un agent edulcorant sythétique l'aspartame.
BE0/215050A 1984-06-27 1985-05-22 Procede pour la preparation de peptides. BE902474A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21622/84A IT1176332B (it) 1984-06-27 1984-06-27 Procedimento per al preparazione di peptidi

Publications (1)

Publication Number Publication Date
BE902474A true BE902474A (fr) 1985-09-16

Family

ID=11184455

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215050A BE902474A (fr) 1984-06-27 1985-05-22 Procede pour la preparation de peptides.

Country Status (7)

Country Link
US (1) US4668625A (fr)
JP (1) JPH0669389B2 (fr)
BE (1) BE902474A (fr)
DE (1) DE3523018A1 (fr)
FR (1) FR2566800B1 (fr)
GB (1) GB2160870B (fr)
IT (1) IT1176332B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2589480A1 (fr) * 1985-11-05 1987-05-07 Hoechst France Procede biologique de preparation de n-(n-benzyloxycarbonyl l-aspartyl-1) l-phenylalaninate de methyle
US4935355A (en) * 1986-04-15 1990-06-19 Synthetech, Inc. Preparation of dipeptides

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3532027A1 (de) * 1985-09-09 1987-03-19 Hoechst Ag Verfahren zur herstellung von aspartam und mittel zu seiner durchfuehrung
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids
US5144073A (en) * 1988-08-31 1992-09-01 Hubbs John C Process for preparation of dipeptides
US5214145A (en) * 1988-08-31 1993-05-25 Eastman Kodak Company Trisubstituted piperazin-2,5-diones
US5252464A (en) * 1989-03-14 1993-10-12 Carlsberg Biotechnology Ltd. A/S Process for producing pentapeptides and intermediates for use in the synthesis
EP0557954B1 (fr) * 1992-02-26 1999-01-07 Chisso Corporation Procédé pour la production de la epsilon-poly-L-lysine
WO2000037486A1 (fr) * 1998-12-22 2000-06-29 Holland Sweetener Company V.O.F. Procede de synthese et d'extraction d'aspartame comprenant une phase de deformylation enzymatique
EP1013663A1 (fr) * 1998-12-22 2000-06-28 Holland Sweetener Company V.O.F. Synthèse et récupération d'aspartame comprenant une étape enzymatique de déformylation
US6617127B2 (en) 1998-12-22 2003-09-09 Holland Sweetener Company, V.O.F. Synthesis and recovery of aspartame involving enzymatic deformylation step
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US7291461B2 (en) * 2002-06-21 2007-11-06 Ptc Therapeutics, Inc. Methods for identifying small molecules that modulate premature translation termination and nonsense mRNA decay
WO2004010106A2 (fr) * 2002-07-24 2004-01-29 Ptc Therapeutics, Inc. Methodes destinees a identifier des petites molecules modulant la terminaison de traduction prematuree et la degradation de l'arnm induite par mutation non-sens
WO2014102778A2 (fr) 2012-12-24 2014-07-03 Ramot At Tel-Aviv University Ltd. Agents permettant de traiter des maladies génétiques résultant de mutations non-sens et leurs procédés d'identification
CN106146378B (zh) * 2015-03-23 2018-09-18 兰州大学 一种酰化高丝氨酸内酯类化合物及其环保应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH590292A5 (fr) * 1973-12-20 1977-07-29 Ciba Geigy Ag
US4264734A (en) * 1977-02-11 1981-04-28 Merck & Co., Inc. Process for producing antibiotic desacetyl 890A10
US4315074A (en) * 1978-05-19 1982-02-09 Pierce Chemical Company Molecular transformation procedure
US4302540A (en) * 1979-10-25 1981-11-24 Kyowa Hakko Kogyo Co., Ltd. Process of producing optically active cephalosporin analogs by enzyme selective deacylation
US4293648A (en) * 1979-12-12 1981-10-06 G. D. Searle & Co. Process for esterification of α-L-aspartyl-L-phenylalanine
US4360593A (en) * 1981-04-03 1982-11-23 Bristol-Myers Company Process of producing a peptide antibiotic with Bacillus circulans
DE3479214D1 (en) * 1983-04-28 1989-09-07 Ajinomoto Kk Process for the production of l-aspartyl-l-phenylalanine methyl ester or l-aspartyl-l-phenylalanine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2589480A1 (fr) * 1985-11-05 1987-05-07 Hoechst France Procede biologique de preparation de n-(n-benzyloxycarbonyl l-aspartyl-1) l-phenylalaninate de methyle
EP0227506A1 (fr) * 1985-11-05 1987-07-01 SOCIETE FRANCAISE HOECHST Société anonyme dite: Procédé biologique de préparation de N-(N-benzyloxycarbonyl L-aspartyl-1) L-phénylalaninate de méthyle
US4935355A (en) * 1986-04-15 1990-06-19 Synthetech, Inc. Preparation of dipeptides

Also Published As

Publication number Publication date
GB8516281D0 (en) 1985-07-31
DE3523018A1 (de) 1986-01-02
IT8421622A1 (it) 1985-12-27
IT1176332B (it) 1987-08-18
FR2566800B1 (fr) 1988-12-23
GB2160870B (en) 1987-07-22
FR2566800A1 (fr) 1986-01-03
IT8421622A0 (it) 1984-06-27
GB2160870A (en) 1986-01-02
JPS6121095A (ja) 1986-01-29
JPH0669389B2 (ja) 1994-09-07
US4668625A (en) 1987-05-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19940531