BE902015A - NEWS 13,14,19,19,20-HEXADEHYDRO-CARBOPROSTACYCLINES AND METHOD OF PREPARATION. - Google Patents

NEWS 13,14,19,19,20-HEXADEHYDRO-CARBOPROSTACYCLINES AND METHOD OF PREPARATION.

Info

Publication number
BE902015A
BE902015A BE0/214703A BE214703A BE902015A BE 902015 A BE902015 A BE 902015A BE 0/214703 A BE0/214703 A BE 0/214703A BE 214703 A BE214703 A BE 214703A BE 902015 A BE902015 A BE 902015A
Authority
BE
Belgium
Prior art keywords
symbols
hydrogen atom
alkyl radical
compounds
carboprostacyclines
Prior art date
Application number
BE0/214703A
Other languages
French (fr)
Inventor
N Mongelli
R Ceserani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE902015A publication Critical patent/BE902015A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/46—Unsaturated compounds containing hydroxy or O-metal groups containing rings other than six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composés de formule (I) dans laquelle R représente un atome d'hydrogène ou un radical alkyle en C1-C6; m représente un nombre entier dont la valeur varie de 1 à 5 ; l'un des symboles R1 et R2 représente un atome d'hydrogène ou un radical alkyle en C1-C6, cependant que l'autre de ces symboles représente le radical hydroxyle; l'un des symboles R3 et R4 représente un atome d'hydrogène, cependant que l'autre de ces symboles représente un atome d'hydrogène ou un radical alkyle en C1-C4; et R5 reprséente un radical alkyle en C1-C6, ainsi que les sels acceptables en pharmacie humaine ou en pharmacie vétérinaire de ces composés. Les composés de formule (I) manifestent une activité d'antithrombooagglutination et de thrombodésagglutination.Compounds of formula (I) in which R represents a hydrogen atom or a C1-C6 alkyl radical; m represents an integer whose value varies from 1 to 5; one of the symbols R1 and R2 represents a hydrogen atom or a C1-C6 alkyl radical, while the other of these symbols represents the hydroxyl radical; one of the symbols R3 and R4 represents a hydrogen atom, while the other of these symbols represents a hydrogen atom or a C1-C4 alkyl radical; and R5 represents a C1-C6 alkyl radical, as well as the salts acceptable in human pharmacy or in veterinary pharmacy of these compounds. The compounds of formula (I) exhibit an antithrombooagglutination and thrombodeagglutination activity.

BE0/214703A 1984-03-26 1985-03-25 NEWS 13,14,19,19,20-HEXADEHYDRO-CARBOPROSTACYCLINES AND METHOD OF PREPARATION. BE902015A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08407794A GB2156343B (en) 1984-03-26 1984-03-26 13,14,19,19,20,20-hexadehydro derivatives of carboprostacyclins and process for their preparation

Publications (1)

Publication Number Publication Date
BE902015A true BE902015A (en) 1985-07-16

Family

ID=10558691

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/214703A BE902015A (en) 1984-03-26 1985-03-25 NEWS 13,14,19,19,20-HEXADEHYDRO-CARBOPROSTACYCLINES AND METHOD OF PREPARATION.

Country Status (5)

Country Link
JP (1) JPS60209546A (en)
BE (1) BE902015A (en)
DE (1) DE3507940A1 (en)
GB (1) GB2156343B (en)
IT (1) IT1183477B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2845770A1 (en) * 1978-10-19 1980-04-30 Schering Ag NEW PROSTACYCLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF

Also Published As

Publication number Publication date
DE3507940A1 (en) 1985-09-26
GB8407794D0 (en) 1984-05-02
JPS60209546A (en) 1985-10-22
GB2156343B (en) 1988-01-13
IT1183477B (en) 1987-10-22
GB2156343A (en) 1985-10-09
IT8519765A0 (en) 1985-03-05

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19910331