BE899790A - 3-(3-hydroxybutoxy)-1-butanol et sa preparation. - Google Patents
3-(3-hydroxybutoxy)-1-butanol et sa preparation.Info
- Publication number
- BE899790A BE899790A BE0/213036A BE213036A BE899790A BE 899790 A BE899790 A BE 899790A BE 0/213036 A BE0/213036 A BE 0/213036A BE 213036 A BE213036 A BE 213036A BE 899790 A BE899790 A BE 899790A
- Authority
- BE
- Belgium
- Prior art keywords
- butanol
- preparation
- hydroxybutoxy
- isomers
- pure
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- HNXKBOZFEUCZHF-UHFFFAOYSA-N 4-(4-hydroxybutan-2-yloxy)butan-2-ol Chemical compound CC(O)CCOC(C)CCO HNXKBOZFEUCZHF-UHFFFAOYSA-N 0.000 title 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N 1-butanol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 1
- ZIYSJVFROIOYRQ-UHFFFAOYSA-N 3-(4-hydroxybutan-2-yloxy)butan-1-ol Chemical compound OCCC(C)OC(C)CCO ZIYSJVFROIOYRQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- AFSYRVDDZGJTIL-UHFFFAOYSA-N oxydibutanol Chemical compound CC(O)CCOCCC(C)O AFSYRVDDZGJTIL-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/04—Saturated ethers
- C07C43/13—Saturated ethers containing hydroxy or O-metal groups
- C07C43/132—Saturated ethers containing hydroxy or O-metal groups both carbon chains being substituted by hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/164—Unsaturated ethers containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1785—Unsaturated ethers containing hydroxy or O-metal groups having more than one ether bound
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21352/83A IT1164254B (it) | 1983-05-30 | 1983-05-30 | 3-(3-idrossibutossi)-1-butanolo e suo metodo di preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE899790A true BE899790A (fr) | 1984-11-30 |
Family
ID=11180528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/213036A BE899790A (fr) | 1983-05-30 | 1984-05-30 | 3-(3-hydroxybutoxy)-1-butanol et sa preparation. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4584321A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS604146A (cg-RX-API-DMAC7.html) |
| BE (1) | BE899790A (cg-RX-API-DMAC7.html) |
| DE (1) | DE3419947A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES8507449A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2547813B1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2142623B (cg-RX-API-DMAC7.html) |
| IT (1) | IT1164254B (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6459003B1 (en) * | 1999-04-01 | 2002-10-01 | Esperion Therapeutics, Inc. | Ether compounds |
| US6713507B2 (en) | 2000-10-11 | 2004-03-30 | Esperion Therapeutics, Inc. | Ether compounds and compositions for cholesterol management and related uses |
| BR0114619A (pt) | 2000-10-11 | 2005-12-13 | Esperion Therapeutics Inc | Composto, composição farmacêutica, métodos para tratar ou prevenir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metabólica, a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas |
| US7304093B2 (en) * | 2000-10-11 | 2007-12-04 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| US20040122091A1 (en) * | 2000-10-11 | 2004-06-24 | Esperion Therapeutics, Inc. | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| BR0114623A (pt) | 2000-10-11 | 2005-12-13 | Esperion Therapeutics Inc | Composto, composição farmacêutica, métodos para tratar ou prevenir uma doença cardiovascular, uma dislipidemia, uma dislipoproteinemia, um distúrbio do metabolismo da glicose, trombótico e associado com o receptor ativado do proliferador de peroxissoma, a doença de alzheimer, a sìndrome x ou sìndrome metabólica, a septicemia, a obesidade, pancreatite, a hipertensão, doença renal, câncer, a inflamação e a impotência, em um paciente e para reduzir o teor de gordura da carne em animal de criação e de colesterol de ovos de aves domésticas |
| MXPA03003020A (es) | 2000-10-11 | 2003-07-14 | Esperion Therapeutics Inc | Compuestos de cetona y composiciones para el control del colesterol y usos relacionados. |
| US20050020694A1 (en) * | 2001-10-11 | 2005-01-27 | Dasseux Jean-Louis Henri | Sulfide and disulfide compounds and compositions for cholesterol management and related uses |
| US20040204502A1 (en) * | 2001-10-11 | 2004-10-14 | Dasseux Jean-Louis Henri | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses |
| US20040192771A1 (en) * | 2001-10-11 | 2004-09-30 | Dasseux Jean-Louis Henri | Ether compounds and compositions for cholesterol management and related uses |
| JP2005522504A (ja) * | 2002-04-10 | 2005-07-28 | エスペリオン セラピューティクス，インコーポレイテッド | パントラクトンおよびパントテン酸誘導体を含むアシル補酵素−ａのミミック、その組成物、ならびにコレステロール管理の方法および関連の使用 |
| HUE036646T2 (hu) | 2003-01-23 | 2018-07-30 | Esperion Therapeutics Inc | Hidroxilvegyületek és kompozícióik koleszterin szabályozására és kapcsolódó alkalmazásokra |
| WO2005068412A1 (en) | 2003-12-24 | 2005-07-28 | Esperion Therapeutics, Inc. | Ketone compounds and compositions for cholesterol management and related uses |
| CN103848726B (zh) * | 2012-12-09 | 2017-09-05 | 河北凯盛医药科技有限公司 | 一种高纯度二羟二丁基醚及其制备方法 |
| CN103304383B (zh) * | 2013-06-18 | 2015-04-08 | 重庆医科大学 | 保胆健素的新合成方法 |
| CN103319316B (zh) * | 2013-06-24 | 2015-06-10 | 大连理工大学 | 一种二羟基二丁醚的绿色制备方法 |
| CN103333057A (zh) * | 2013-06-24 | 2013-10-02 | 大连理工大学 | 一种二羟基二丁醚的制备方法 |
| CN104230674A (zh) * | 2014-08-28 | 2014-12-24 | 成都邦泽生物医药科技有限公司 | 一种二羟基二丁醚的制备方法 |
| WO2016149191A1 (en) | 2015-03-13 | 2016-09-22 | Esperion Therapeutics, Inc. | Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease |
| MA41793A (fr) | 2015-03-16 | 2018-01-23 | Esperion Therapeutics Inc | Associations de doses fixes comprenant du etc1002 et une ou plusieurs statines permettant de traiter ou de réduire un risque cardiovasculaire |
| EP4438114A3 (en) | 2019-06-21 | 2024-12-25 | Esperion Therapeutics, Inc. | Methods of making bempedoic acid and compositions of the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT957008B (it) * | 1967-11-09 | 1973-10-10 | Luso Farmaco Inst | Processo per la preparazione di eteri simmetrici di glicoli re canti ossidrili primari e secon dari |
| DE2218935C3 (de) * | 1972-04-19 | 1980-01-31 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von wäßrigen Lösungen von N-Vinylpyrrolidonpolymerisaten |
-
1983
- 1983-05-30 IT IT21352/83A patent/IT1164254B/it active Protection Beyond IP Right Term
-
1984
- 1984-04-23 US US06/603,134 patent/US4584321A/en not_active Expired - Lifetime
- 1984-05-03 GB GB08411356A patent/GB2142623B/en not_active Expired
- 1984-05-25 ES ES532802A patent/ES8507449A1/es not_active Expired
- 1984-05-28 JP JP59108268A patent/JPS604146A/ja active Granted
- 1984-05-28 DE DE19843419947 patent/DE3419947A1/de active Granted
- 1984-05-30 BE BE0/213036A patent/BE899790A/fr not_active IP Right Cessation
- 1984-05-30 FR FR848408571A patent/FR2547813B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3419947C2 (cg-RX-API-DMAC7.html) | 1987-11-26 |
| ES532802A0 (es) | 1985-10-01 |
| FR2547813B1 (fr) | 1989-01-27 |
| GB8411356D0 (en) | 1984-06-06 |
| GB2142623A (en) | 1985-01-23 |
| IT8321352A0 (it) | 1983-05-30 |
| ES8507449A1 (es) | 1985-10-01 |
| JPS604146A (ja) | 1985-01-10 |
| GB2142623B (en) | 1987-04-15 |
| IT8321352A1 (it) | 1984-11-30 |
| US4584321A (en) | 1986-04-22 |
| DE3419947A1 (de) | 1984-12-06 |
| FR2547813A1 (fr) | 1984-12-28 |
| JPS6241702B2 (cg-RX-API-DMAC7.html) | 1987-09-04 |
| IT1164254B (it) | 1987-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE20 | Patent expired |
Owner name: *ISTITUTO LUSO FARMACO D ITALIA S.P.A. Effective date: 20040530 |