BE899691A - Preparation medicamenteuse solide a deux phases et son procede d'obtention. - Google Patents
Preparation medicamenteuse solide a deux phases et son procede d'obtention.Info
- Publication number
- BE899691A BE899691A BE0/212957A BE212957A BE899691A BE 899691 A BE899691 A BE 899691A BE 0/212957 A BE0/212957 A BE 0/212957A BE 212957 A BE212957 A BE 212957A BE 899691 A BE899691 A BE 899691A
- Authority
- BE
- Belgium
- Prior art keywords
- solid
- drug preparation
- phase drug
- obtaining same
- nifedipine
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 abstract 3
- 229960001597 nifedipine Drugs 0.000 abstract 3
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
Abstract
L'invention concerne une préparation médicamenteurse solide à deux phases, caractérisée en ce qu'elle contient une association d'un coprécipité de nifédipine dans lequel la nifédipine se présente sous une forme non cristalline et d'une fraction cristalline de nifédipine. Application au traitement de maladies coronariennes et de troubles circulatoires.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833318649 DE3318649A1 (de) | 1983-05-21 | 1983-05-21 | Zweiphasenformulierung |
Publications (1)
Publication Number | Publication Date |
---|---|
BE899691A true BE899691A (fr) | 1984-11-19 |
Family
ID=6199643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/212957A BE899691A (fr) | 1983-05-21 | 1984-05-17 | Preparation medicamenteuse solide a deux phases et son procede d'obtention. |
Country Status (29)
Country | Link |
---|---|
US (1) | US4562069A (fr) |
EP (1) | EP0126379B1 (fr) |
JP (1) | JPS59222475A (fr) |
AT (2) | ATE42198T1 (fr) |
AU (1) | AU564263B2 (fr) |
BE (1) | BE899691A (fr) |
CA (1) | CA1228550A (fr) |
CH (1) | CH658190A5 (fr) |
CS (1) | CS250663B2 (fr) |
DD (1) | DD222495A5 (fr) |
DE (2) | DE3318649A1 (fr) |
DK (1) | DK163278C (fr) |
ES (1) | ES8505817A1 (fr) |
FI (1) | FI82376C (fr) |
FR (1) | FR2550092B1 (fr) |
GB (1) | GB2139892B (fr) |
GR (1) | GR82018B (fr) |
HK (1) | HK63789A (fr) |
HU (1) | HU193287B (fr) |
IL (1) | IL71871A (fr) |
IT (1) | IT1218848B (fr) |
KE (1) | KE3889A (fr) |
NO (1) | NO164817C (fr) |
NZ (1) | NZ208214A (fr) |
PH (1) | PH21989A (fr) |
PL (1) | PL142890B1 (fr) |
PT (1) | PT78611B (fr) |
SG (1) | SG36089G (fr) |
ZA (1) | ZA843769B (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2525108B1 (fr) * | 1982-04-19 | 1989-05-12 | Elan Corp Ltd | Medicaments a haut degre de solubilite et procede pour leur obtention |
DE3580384D1 (de) * | 1984-04-09 | 1990-12-13 | Toyo Boseki | Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle. |
NL194389C (nl) * | 1984-06-14 | 2002-03-04 | Novartis Ag | Werkwijze voor het bereiden van een vaste dispersie van een farmaceutisch actief middel dat een lage oplosbaarheid in water heeft, in een vaste matrix van een in water oplosbaar polyalkyleenglycol als drager. |
DE3424553A1 (de) * | 1984-07-04 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen mit dihydropyridinen und verfahren zu ihrer herstellung |
DE3438830A1 (de) * | 1984-10-23 | 1986-04-30 | Rentschler Arzneimittel | Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung |
US4867984A (en) * | 1984-11-06 | 1989-09-19 | Nagin K. Patel | Drug in bead form and process for preparing same |
IT1187751B (it) * | 1985-10-15 | 1987-12-23 | Eurand Spa | Procedimento per la preparazione di formulazioni solidi di nifedipina ad elevata biodisponibilita' e ad effetto prolungato e formulazioni cosi' ottenute |
US5198226A (en) * | 1986-01-30 | 1993-03-30 | Syntex (U.S.A.) Inc. | Long acting nicardipine hydrochloride formulation |
US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
IE63321B1 (en) * | 1986-02-03 | 1995-04-05 | Elan Corp Plc | Drug delivery system |
SE8601624D0 (sv) * | 1986-04-11 | 1986-04-11 | Haessle Ab | New pharmaceutical preparations |
DE3636123A1 (de) * | 1986-10-23 | 1988-05-05 | Rentschler Arzneimittel | Arzneizubereitungen zur oralen verabreichung, die als einzeldosis 10 bis 240 mg dihydropyridin enthalten |
DE3639073A1 (de) * | 1986-11-14 | 1988-05-26 | Klinge Co Chem Pharm Fab | Feste arzneizubereitungen und verfahren zu ihrer herstellung |
US5015479A (en) * | 1987-02-02 | 1991-05-14 | Seamus Mulligan | Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine |
DE3720757A1 (de) * | 1987-06-24 | 1989-01-05 | Bayer Ag | Dhp-manteltablette |
US4954346A (en) * | 1988-06-08 | 1990-09-04 | Ciba-Geigy Corporation | Orally administrable nifedipine solution in a solid light resistant dosage form |
GB8903328D0 (en) * | 1989-02-14 | 1989-04-05 | Ethical Pharma Ltd | Nifedipine-containing pharmaceutical compositions and process for the preparation thereof |
HU203041B (en) * | 1989-03-14 | 1991-05-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin |
GB9025251D0 (en) * | 1990-11-20 | 1991-01-02 | Solomon Montague C | Nifedipine dosage forms |
DE4130173A1 (de) * | 1991-09-11 | 1993-03-18 | Bayer Ag | Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US6726930B1 (en) * | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) * | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US5543099A (en) * | 1994-09-29 | 1996-08-06 | Hallmark Pharmaceutical, Inc. | Process to manufacture micronized nifedipine granules for sustained release medicaments |
CA2231195C (fr) * | 1996-07-08 | 2003-01-21 | Edward Mendell Co., Inc. | Matrice a liberation prolongee pour medicaments insolubles en doses elevees |
EP0852141A1 (fr) * | 1996-08-16 | 1998-07-08 | J.B. Chemicals & Pharmaceuticals Ltd. | Composition pharmaceutique à libération prolongée contenant de la nifédipine et procédé pour sa préparation |
US5891469A (en) * | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
US5922352A (en) * | 1997-01-31 | 1999-07-13 | Andrx Pharmaceuticals, Inc. | Once daily calcium channel blocker tablet having a delayed release core |
US5837379A (en) * | 1997-01-31 | 1998-11-17 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
IN186245B (fr) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
US6056977A (en) * | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6485748B1 (en) | 1997-12-12 | 2002-11-26 | Andrx Pharmaceuticals, Inc. | Once daily pharmaceutical tablet having a unitary core |
US20040013613A1 (en) * | 2001-05-18 | 2004-01-22 | Jain Rajeev A | Rapidly disintegrating solid oral dosage form |
US8293277B2 (en) * | 1998-10-01 | 2012-10-23 | Alkermes Pharma Ireland Limited | Controlled-release nanoparticulate compositions |
US8236352B2 (en) | 1998-10-01 | 2012-08-07 | Alkermes Pharma Ireland Limited | Glipizide compositions |
EP1117384A1 (fr) * | 1998-10-01 | 2001-07-25 | Elan Pharma International Limited | Liberation regulee de compositions nanoparticulaires |
US7521068B2 (en) * | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6969529B2 (en) * | 2000-09-21 | 2005-11-29 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising copolymers of vinyl pyrrolidone and vinyl acetate as surface stabilizers |
US6168806B1 (en) | 1999-03-05 | 2001-01-02 | Fang-Yu Lee | Orally administrable nifedipine pellet and process for the preparation thereof |
CA2352211C (fr) * | 1999-09-30 | 2009-03-24 | Edward Mendell Co., Inc. | Systemes de matrice a liberation prolongee pour medicaments hautement solubles |
US20040156872A1 (en) * | 2000-05-18 | 2004-08-12 | Elan Pharma International Ltd. | Novel nimesulide compositions |
US7198795B2 (en) | 2000-09-21 | 2007-04-03 | Elan Pharma International Ltd. | In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions |
US7276249B2 (en) | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
WO2003033462A2 (fr) * | 2001-10-15 | 2003-04-24 | The Regents Of The University Of Michigan | Systemes et procedes de fabrication de polymorphes cristallins |
DK1471887T3 (da) | 2002-02-04 | 2010-06-07 | Elan Pharma Int Ltd | Nanopartikelkompositioner der har lysozym som overfladestabiliseringsmiddel |
CA2492488A1 (fr) * | 2002-07-16 | 2004-01-22 | Elan Pharma International, Ltd. | Compositions pour doses liquides d'agents actifs nanoparticulaires stables |
CN101702878B (zh) * | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | 可溶性差的药物的药物组合物 |
EP2755637B1 (fr) * | 2011-09-13 | 2020-08-12 | ISP Investments LLC | Dispersion solide de composés peu solubles comprenant une crospovidone et au moins un polymère hydrosoluble |
US20130259931A1 (en) * | 2012-03-30 | 2013-10-03 | Bandi Parthasaradhi Reddy | Oral pharmaceutical compositions of nebivolol and process for their preparation |
US8313774B1 (en) * | 2012-06-26 | 2012-11-20 | Magnifica Inc. | Oral solid composition |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
JPS5446837A (en) * | 1977-09-19 | 1979-04-13 | Kanebo Ltd | Easily absorbable nifedipin composition, its preparation, and anti-stenocardia containing the same |
EP0001247A1 (fr) * | 1977-09-14 | 1979-04-04 | Kanebo, Ltd. | Composition pharmaceutique contenant de la nifédipine et procédé pour sa préparation. |
EP0012523B2 (fr) * | 1978-11-20 | 1988-02-03 | American Home Products Corporation | Compositions thérapeutiques à biodisponibilité accrue et procédé pour leur préparation |
DE3013839A1 (de) * | 1979-04-13 | 1980-10-30 | Freunt Ind Co Ltd | Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung |
CA1146866A (fr) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Procede de production d'un compose pharmaceutique a liberation continue sous forme solide |
JPS56110612A (en) * | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Readily disintegrable and absorbable compression molded article of slightly soluble drug |
DE3033919A1 (de) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
JPS5668619A (en) * | 1980-10-09 | 1981-06-09 | Yamanouchi Pharmaceut Co Ltd | Nifedipine-containing solid composition |
JPS5785316A (en) * | 1980-11-14 | 1982-05-28 | Kanebo Ltd | Preparation of easily absorbable nifedipine preparation |
JPS57167911A (en) * | 1981-04-09 | 1982-10-16 | Kyoto Yakuhin Kogyo Kk | Liquid pharmaceutical of nifedipine |
JPS5846019A (ja) * | 1981-09-14 | 1983-03-17 | Kanebo Ltd | 持続性ニフエジピン製剤 |
EP0078430B2 (fr) * | 1981-10-29 | 1993-02-10 | Bayer Ag | Procédé de fabrication de préparations pharmaceutiques solides à libération rapide de dihydropyridines |
DE3142853A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen mit nifedipin und verfahren zu ihrer herstellung |
JPS5877811A (ja) * | 1981-11-04 | 1983-05-11 | Kanebo Ltd | 安定な易吸収性ニフエジピン製剤の製法 |
-
1983
- 1983-05-21 DE DE19833318649 patent/DE3318649A1/de not_active Withdrawn
-
1984
- 1984-05-02 US US06/606,104 patent/US4562069A/en not_active Expired - Lifetime
- 1984-05-08 NO NO841838A patent/NO164817C/no unknown
- 1984-05-09 EP EP84105235A patent/EP0126379B1/fr not_active Expired
- 1984-05-09 DE DE8484105235T patent/DE3477733D1/de not_active Expired
- 1984-05-09 AT AT84105235T patent/ATE42198T1/de not_active IP Right Cessation
- 1984-05-16 AU AU28060/84A patent/AU564263B2/en not_active Ceased
- 1984-05-16 ES ES532515A patent/ES8505817A1/es not_active Expired
- 1984-05-17 FI FI841995A patent/FI82376C/fi not_active IP Right Cessation
- 1984-05-17 BE BE0/212957A patent/BE899691A/fr not_active IP Right Cessation
- 1984-05-17 JP JP59097625A patent/JPS59222475A/ja active Pending
- 1984-05-17 DK DK247284A patent/DK163278C/da active
- 1984-05-18 AT AT0164884A patent/AT390879B/de active
- 1984-05-18 FR FR8407731A patent/FR2550092B1/fr not_active Expired
- 1984-05-18 PH PH30694A patent/PH21989A/en unknown
- 1984-05-18 NZ NZ208214A patent/NZ208214A/xx unknown
- 1984-05-18 CS CS843770A patent/CS250663B2/cs unknown
- 1984-05-18 HU HU841934A patent/HU193287B/hu not_active IP Right Cessation
- 1984-05-18 PL PL1984247744A patent/PL142890B1/pl unknown
- 1984-05-18 DD DD84263172A patent/DD222495A5/de not_active IP Right Cessation
- 1984-05-18 IT IT21013/84A patent/IT1218848B/it active
- 1984-05-18 PT PT78611A patent/PT78611B/pt not_active IP Right Cessation
- 1984-05-18 CH CH2465/84A patent/CH658190A5/de not_active IP Right Cessation
- 1984-05-18 CA CA000454635A patent/CA1228550A/fr not_active Expired
- 1984-05-18 GB GB08412820A patent/GB2139892B/en not_active Expired
- 1984-05-18 IL IL71871A patent/IL71871A/xx unknown
- 1984-05-18 ZA ZA843769A patent/ZA843769B/xx unknown
- 1984-05-21 GR GR74767A patent/GR82018B/el unknown
-
1989
- 1989-06-07 SG SG360/89A patent/SG36089G/en unknown
- 1989-06-21 KE KE3889A patent/KE3889A/xx unknown
- 1989-08-10 HK HK637/89A patent/HK63789A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE899691A (fr) | Preparation medicamenteuse solide a deux phases et son procede d'obtention. | |
IL83925A0 (en) | Compositions for treatment of skin disorders | |
AU6767587A (en) | Pharmaceutical compositions | |
EP0243002A3 (en) | Pharmaceutical composition for the treatment of periodontal diseases | |
MA22340A1 (fr) | Pain de toilette nettoyant doux pour la peau avec auxiliaire adoucissant /hydratant pour la peau a base de silicone | |
FR2449084A1 (fr) | Nouveaux derives de geldanamycine, leur procede de preparation et leur application en therapeutique | |
BE1002406A5 (fr) | Compositions pharmaceutiques. | |
FR2567758B1 (fr) | Compositions therapeutiques a base de ginkgolides pour le traitement ou la prevention des maladies provoquees par l'acether du facteur d'activation des plaquettes (paf-acether) | |
MA26608A1 (fr) | Procede de preparation d'une composition pharmaceutique destinee au traitement de l'insuffisance cardiaque. | |
CA2006658A1 (fr) | Une substance anticoagulante tiree de l'urine | |
EP0197488A3 (fr) | Dérivés 1,4-dihydropyridine, leur procédé de préparation, médicament les contenant et leur utilisation | |
FR2717080B1 (fr) | Utilisation de l'éliprodil et de ses énantiomères pour la préparation de médicaments utiles dans le traitement des neuropathies périphériques et des maladies neurodégénératives centrales. | |
AU581599B2 (en) | New peptide compounds having a lactone or cycloamide structure | |
FR2644063B1 (fr) | Compositions dermatologiques et cosmetologiques a base d'alcoylcarboxamide et de sel de zinc utiles dans le traitement de la dermite seborrheique et/ou des troubles de la seborrhee | |
IT8219482A0 (it) | Composizione farmaceutica per la cura di affezioni della cavita'orale. | |
MA24682A1 (fr) | Formes polymorphes nouvelles de cipamfylline, procede pour leur preparation et compositions les contenant | |
ZA875847B (en) | Pharmaceutical compositions for the treatment of occlusive vascular diseases | |
FR2619712B1 (fr) | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la schizophrenie | |
BE899612A (fr) | Derives 1 alpha, 25-dihydroxiles de la vitamine d2 et produits intermediaires pour leur preparation et compositions pharmaceutiques renfermant ces derives. | |
FR2614203B1 (fr) | Composition pharmaceutique pour le traitement des maladies de la peau et son procede de preparation. | |
MA24683A1 (fr) | Formes polymorphes de dofetilide, procede pour leur preparation et composition les contenant. | |
CA2217463A1 (fr) | Utilisation de la sulbutiamine pour l'obtention de compositions pharmaceutiques utiles dans le traitement de certains troubles psychomoteurs et psycho-intellectuels | |
RO86562A2 (fr) | Composition vegetale medicamenteuse pour le traitement des affectionsbiliares | |
OA09130A (fr) | Utilisation de dérivés de l'acide aza-2 bicyclooctane [2.2.2] carboxylique-3 pour l'obtention de médicaments destinés au traitement des maladies consécutives à l'altération de la paroi vasculaire ainsi qu'aux troubles de la microcirculation. | |
IL82317A (en) | 1,4-dihydropyridine derivatives,processes for their preparation and medicaments containing these compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: BAYER A.G. Effective date: 19920531 |