PT78611B - Process to prepare a two-phase pharmaceutical composition with niphedypine <dimethylic acid esther 1,4-di-hydro-2,6-dimethyl- 4-(2 nitrophenyl)-3,5-pyridine-dicarboxilic> in non-crystallin e and crystalline forms - Google Patents

Process to prepare a two-phase pharmaceutical composition with niphedypine <dimethylic acid esther 1,4-di-hydro-2,6-dimethyl- 4-(2 nitrophenyl)-3,5-pyridine-dicarboxilic> in non-crystallin e and crystalline forms

Info

Publication number
PT78611B
PT78611B PT78611A PT7861184A PT78611B PT 78611 B PT78611 B PT 78611B PT 78611 A PT78611 A PT 78611A PT 7861184 A PT7861184 A PT 7861184A PT 78611 B PT78611 B PT 78611B
Authority
PT
Portugal
Prior art keywords
nifedipine
niphedypine
dimethylic
dicarboxilic
crystallin
Prior art date
Application number
PT78611A
Other languages
Portuguese (pt)
Other versions
PT78611A (en
Inventor
Ahmed Hegasy
Roland Rupp
Klaus-Dieter Raemsch
Helmut Luchtenberg
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6199643&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT78611(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PT78611A publication Critical patent/PT78611A/en
Publication of PT78611B publication Critical patent/PT78611B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

In the treatment of cardiovascular and coronary disorders by administering to a patent suffering therefrom a solid preparation comprising nifedipine, the improvement which comprises administering such nifedipine in the form of a solid two-phase medicament formulation comprising a nifedipine coprecipitate, in which the nifedipine is present in a non-crystalline form, and crystalline nifedipine, whereby the nifedipine rapidly enters the blood stream in a relatively high concentration which is maintained for a relatively long time.
PT78611A 1983-05-21 1984-05-18 Process to prepare a two-phase pharmaceutical composition with niphedypine <dimethylic acid esther 1,4-di-hydro-2,6-dimethyl- 4-(2 nitrophenyl)-3,5-pyridine-dicarboxilic> in non-crystallin e and crystalline forms PT78611B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833318649 DE3318649A1 (en) 1983-05-21 1983-05-21 TWO-PHASE FORMULATION

Publications (2)

Publication Number Publication Date
PT78611A PT78611A (en) 1984-06-01
PT78611B true PT78611B (en) 1986-07-15

Family

ID=6199643

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78611A PT78611B (en) 1983-05-21 1984-05-18 Process to prepare a two-phase pharmaceutical composition with niphedypine <dimethylic acid esther 1,4-di-hydro-2,6-dimethyl- 4-(2 nitrophenyl)-3,5-pyridine-dicarboxilic> in non-crystallin e and crystalline forms

Country Status (29)

Country Link
US (1) US4562069A (en)
EP (1) EP0126379B1 (en)
JP (1) JPS59222475A (en)
AT (2) ATE42198T1 (en)
AU (1) AU564263B2 (en)
BE (1) BE899691A (en)
CA (1) CA1228550A (en)
CH (1) CH658190A5 (en)
CS (1) CS250663B2 (en)
DD (1) DD222495A5 (en)
DE (2) DE3318649A1 (en)
DK (1) DK163278C (en)
ES (1) ES532515A0 (en)
FI (1) FI82376C (en)
FR (1) FR2550092B1 (en)
GB (1) GB2139892B (en)
GR (1) GR82018B (en)
HK (1) HK63789A (en)
HU (1) HU193287B (en)
IL (1) IL71871A (en)
IT (1) IT1218848B (en)
KE (1) KE3889A (en)
NO (1) NO164817C (en)
NZ (1) NZ208214A (en)
PH (1) PH21989A (en)
PL (1) PL142890B1 (en)
PT (1) PT78611B (en)
SG (1) SG36089G (en)
ZA (1) ZA843769B (en)

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US4867984A (en) * 1984-11-06 1989-09-19 Nagin K. Patel Drug in bead form and process for preparing same
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US4940556A (en) * 1986-01-30 1990-07-10 Syntex (U.S.A.) Inc. Method of preparing long acting formulation
US5198226A (en) * 1986-01-30 1993-03-30 Syntex (U.S.A.) Inc. Long acting nicardipine hydrochloride formulation
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DE3639073A1 (en) * 1986-11-14 1988-05-26 Klinge Co Chem Pharm Fab SOLID PHARMACEUTICAL PREPARATIONS AND METHOD FOR THEIR PRODUCTION
US5015479A (en) * 1987-02-02 1991-05-14 Seamus Mulligan Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine
DE3720757A1 (en) * 1987-06-24 1989-01-05 Bayer Ag DHP COAT TABLET
US4954346A (en) * 1988-06-08 1990-09-04 Ciba-Geigy Corporation Orally administrable nifedipine solution in a solid light resistant dosage form
GB8903328D0 (en) * 1989-02-14 1989-04-05 Ethical Pharma Ltd Nifedipine-containing pharmaceutical compositions and process for the preparation thereof
HU203041B (en) * 1989-03-14 1991-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing pharmaceutical compositions of controlled releasing factor containing nifedipin
GB9025251D0 (en) * 1990-11-20 1991-01-02 Solomon Montague C Nifedipine dosage forms
DE4130173A1 (en) * 1991-09-11 1993-03-18 Bayer Ag PHARMACEUTICAL PREPARATIONS WITH A SPECIAL CRYSTAL MODIFICATION OF 1,4-DIHYDRO-2,6-DIMETHYL-4- (3-NITROPHENYL) -3,5-PYRIDINDICARBONIC ACID ISOPROPYL- (2-METHOXYETHYL) ESTER
US5455046A (en) * 1993-09-09 1995-10-03 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
US5662933A (en) * 1993-09-09 1997-09-02 Edward Mendell Co., Inc. Controlled release formulation (albuterol)
US6726930B1 (en) * 1993-09-09 2004-04-27 Penwest Pharmaceuticals Co. Sustained release heterodisperse hydrogel systems for insoluble drugs
US5543099A (en) * 1994-09-29 1996-08-06 Hallmark Pharmaceutical, Inc. Process to manufacture micronized nifedipine granules for sustained release medicaments
AU695734B2 (en) 1996-07-08 1998-08-20 Penwest Pharmaceuticals Co. Sustained release matrix for high-dose insoluble drugs
EP0852141A1 (en) * 1996-08-16 1998-07-08 J.B. Chemicals &amp; Pharmaceuticals Ltd. Nifedipine containing pharmaceutical extended release composition and a process for the preparation thereof
US5891469A (en) * 1997-04-02 1999-04-06 Pharmos Corporation Solid Coprecipitates for enhanced bioavailability of lipophilic substances
US5922352A (en) * 1997-01-31 1999-07-13 Andrx Pharmaceuticals, Inc. Once daily calcium channel blocker tablet having a delayed release core
US5837379A (en) * 1997-01-31 1998-11-17 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
IN186245B (en) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
US6056977A (en) 1997-10-15 2000-05-02 Edward Mendell Co., Inc. Once-a-day controlled release sulfonylurea formulation
US6485748B1 (en) 1997-12-12 2002-11-26 Andrx Pharmaceuticals, Inc. Once daily pharmaceutical tablet having a unitary core
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Also Published As

Publication number Publication date
CA1228550A (en) 1987-10-27
IL71871A (en) 1987-07-31
CH658190A5 (en) 1986-10-31
ZA843769B (en) 1984-12-24
FR2550092B1 (en) 1987-11-20
FR2550092A1 (en) 1985-02-08
IT1218848B (en) 1990-04-24
DD222495A5 (en) 1985-05-22
GB2139892A (en) 1984-11-21
NO164817C (en) 1990-12-19
ES8505817A1 (en) 1985-06-16
US4562069A (en) 1985-12-31
PT78611A (en) 1984-06-01
FI82376B (en) 1990-11-30
FI82376C (en) 1991-03-11
IL71871A0 (en) 1984-09-30
FI841995A0 (en) 1984-05-17
GR82018B (en) 1984-12-12
FI841995A (en) 1984-11-22
DK247284A (en) 1984-11-22
JPS59222475A (en) 1984-12-14
IT8421013A0 (en) 1984-05-18
EP0126379A2 (en) 1984-11-28
GB2139892B (en) 1987-04-23
EP0126379B1 (en) 1989-04-19
AT390879B (en) 1990-07-10
ATA164884A (en) 1990-01-15
DK163278C (en) 1992-09-07
GB8412820D0 (en) 1984-06-27
PL142890B1 (en) 1987-12-31
PH21989A (en) 1988-05-02
HU193287B (en) 1987-09-28
KE3889A (en) 1989-09-01
DK247284D0 (en) 1984-05-17
CS250663B2 (en) 1987-05-14
DE3477733D1 (en) 1989-05-24
BE899691A (en) 1984-11-19
AU2806084A (en) 1984-11-22
DE3318649A1 (en) 1984-11-22
EP0126379A3 (en) 1986-07-09
NO841838L (en) 1984-11-22
ES532515A0 (en) 1985-06-16
NZ208214A (en) 1986-10-08
DK163278B (en) 1992-02-17
SG36089G (en) 1989-10-13
HK63789A (en) 1989-08-18
HUT34690A (en) 1985-04-28
AU564263B2 (en) 1987-08-06
ATE42198T1 (en) 1989-05-15
NO164817B (en) 1990-08-13
PL247744A1 (en) 1985-11-05

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