BE899085A - Intermediaires pour carbapenemes - Google Patents
Intermediaires pour carbapenemesInfo
- Publication number
- BE899085A BE899085A BE0/212513A BE212513A BE899085A BE 899085 A BE899085 A BE 899085A BE 0/212513 A BE0/212513 A BE 0/212513A BE 212513 A BE212513 A BE 212513A BE 899085 A BE899085 A BE 899085A
- Authority
- BE
- Belgium
- Prior art keywords
- carbapenems
- intermediates
- trimethylchlorosilane
- trialkylamine
- circumvent
- Prior art date
Links
- 229940041011 carbapenems Drugs 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
- 239000005051 trimethylchlorosilane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47244383A | 1983-03-07 | 1983-03-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE899085A true BE899085A (fr) | 1984-09-06 |
Family
ID=23875532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE0/212513A BE899085A (fr) | 1983-03-07 | 1984-03-06 | Intermediaires pour carbapenemes |
Country Status (10)
| Country | Link |
|---|---|
| JP (3) | JPS59170096A (nl) |
| BE (1) | BE899085A (nl) |
| CA (1) | CA1220215A (nl) |
| CY (1) | CY1447A (nl) |
| DE (1) | DE3408196A1 (nl) |
| FR (1) | FR2542317B1 (nl) |
| GB (1) | GB2136009B (nl) |
| HK (1) | HK84588A (nl) |
| IT (1) | IT1175944B (nl) |
| MY (1) | MY8800117A (nl) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683296A (en) * | 1983-03-07 | 1987-07-28 | Bristol-Myers Company | Carbapenem intermediates |
| US5340927A (en) * | 1989-07-18 | 1994-08-23 | Merck & Co., Inc. | Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| US4174316A (en) * | 1978-08-14 | 1979-11-13 | Merck & Co., Inc. | 4-Iodomethylazetidin-2-one |
| US4290947A (en) * | 1979-04-27 | 1981-09-22 | Merck & Co., Inc. | Process for the preparation of thienamycin and intermediates |
| PT71553B (en) * | 1979-07-23 | 1981-12-14 | Merck & Co Inc | Process for the preparation of thienamycin and intermediates |
| US4360684A (en) * | 1981-04-08 | 1982-11-23 | Merck & Co., Inc. | Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid |
| JPS58103358A (ja) * | 1981-10-23 | 1983-06-20 | メルク・エンド・カムパニ−・インコ−ポレ−テツド | 抗生物質中間体の製造方法 |
| CA1190236A (en) * | 1981-10-23 | 1985-07-09 | Edward J.J. Grabowski | Antibiotic synthesis |
-
1984
- 1984-02-10 CA CA000447155A patent/CA1220215A/en not_active Expired
- 1984-03-02 IT IT19891/84A patent/IT1175944B/it active
- 1984-03-06 BE BE0/212513A patent/BE899085A/fr not_active IP Right Cessation
- 1984-03-06 GB GB08405878A patent/GB2136009B/en not_active Expired
- 1984-03-06 DE DE19843408196 patent/DE3408196A1/de active Granted
- 1984-03-06 FR FR8403469A patent/FR2542317B1/fr not_active Expired
- 1984-03-07 JP JP59042202A patent/JPS59170096A/ja active Granted
-
1988
- 1988-10-20 HK HK845/88A patent/HK84588A/xx not_active IP Right Cessation
- 1988-12-30 MY MY117/88A patent/MY8800117A/xx unknown
-
1989
- 1989-03-10 CY CY1447A patent/CY1447A/xx unknown
-
1991
- 1991-11-28 JP JP3355457A patent/JPH0827168A/ja active Pending
-
1996
- 1996-08-28 JP JP8226195A patent/JPH09176113A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2542317A1 (fr) | 1984-09-14 |
| CA1220215A (en) | 1987-04-07 |
| IT1175944B (it) | 1987-08-12 |
| DE3408196C2 (nl) | 1992-03-19 |
| JPH0564157B2 (nl) | 1993-09-14 |
| JPH09176113A (ja) | 1997-07-08 |
| GB8405878D0 (en) | 1984-04-11 |
| JPS59170096A (ja) | 1984-09-26 |
| GB2136009A (en) | 1984-09-12 |
| JPH0827168A (ja) | 1996-01-30 |
| HK84588A (en) | 1988-10-28 |
| CY1447A (en) | 1989-03-10 |
| MY8800117A (en) | 1988-12-31 |
| GB2136009B (en) | 1986-04-30 |
| DE3408196A1 (de) | 1984-09-13 |
| IT8419891A0 (it) | 1984-03-02 |
| FR2542317B1 (fr) | 1987-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RE | Patent lapsed |
Owner name: BRISTOL-MYERS CY Effective date: 19980331 |