BE889563A - Steroides doux exercant une activite anti-inflammatoire - Google Patents

Steroides doux exercant une activite anti-inflammatoire Download PDF

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Publication number
BE889563A
BE889563A BE2/59253A BE2059253A BE889563A BE 889563 A BE889563 A BE 889563A BE 2/59253 A BE2/59253 A BE 2/59253A BE 2059253 A BE2059253 A BE 2059253A BE 889563 A BE889563 A BE 889563A
Authority
BE
Belgium
Prior art keywords
emi
group
carbon atoms
lower alkyl
alkyl
Prior art date
Application number
BE2/59253A
Other languages
English (en)
French (fr)
Inventor
N S Bodor
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BE889563A publication Critical patent/BE889563A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE2/59253A 1980-07-10 1981-07-09 Steroides doux exercant une activite anti-inflammatoire BE889563A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10

Publications (1)

Publication Number Publication Date
BE889563A true BE889563A (fr) 1981-11-03

Family

ID=22611544

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2/59253A BE889563A (fr) 1980-07-10 1981-07-09 Steroides doux exercant une activite anti-inflammatoire

Country Status (4)

Country Link
JP (1) JPS5745200A (nl)
BE (1) BE889563A (nl)
SU (1) SU1318169A3 (nl)
ZA (1) ZA814440B (nl)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088167A1 (en) * 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US7101866B2 (en) 2000-08-05 2006-09-05 Glaxo Group Limited Anti-inflammatory androstane derivative
US7125985B2 (en) 2000-08-05 2006-10-24 Glaxo Group Limited Compounds useful in the manufacture of an anti-inflammatory androstane derivative
WO2007099548A3 (en) * 2006-01-27 2008-10-09 Sun Pharmaceutical Ind Ltd Novel 11 beta - hydroxyandrosta-4-ene-3-ones
US7541350B2 (en) 2000-08-05 2009-06-02 Glaxo Group Limited Formulation containing anti-inflammatory androstane derivative
US7592329B2 (en) 2002-02-04 2009-09-22 Glaxo Group Limited Crystalline complexes of fluticasone-2-furoate
US8163723B2 (en) 2002-06-14 2012-04-24 Cipla Limited Combination of azelastine and steroids
WO2018232007A1 (en) 2017-06-13 2018-12-20 Bodor Laboratories, Inc. Potent soft anti-inflammatory corticosteroid compounds and uses therof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4607028A (en) * 1983-08-18 1986-08-19 Ciba-Geigy Corporation Novel carboxylic acid esters
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
DE19947235A1 (de) * 1999-09-30 2001-04-05 Asta Medica Ag Neue Kombination von Loteprednol und beta¶2¶-Adrenorezeptor-Agonisten
ES2339351T3 (es) * 2003-06-19 2010-05-19 Nicholas S. Bodor Mejora de la actividad y/o duracion de la accion de esteroides anti-inflamatorios blandos para la aplicacion topica u otra local.
GB0523251D0 (en) * 2005-11-15 2005-12-21 Glaxo Group Ltd Novel compounds
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498321B2 (en) 2000-08-05 2009-03-03 Glaxo Group Limited 17β-carbothioate 17α-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
US7101866B2 (en) 2000-08-05 2006-09-05 Glaxo Group Limited Anti-inflammatory androstane derivative
US7125985B2 (en) 2000-08-05 2006-10-24 Glaxo Group Limited Compounds useful in the manufacture of an anti-inflammatory androstane derivative
US7144845B2 (en) 2000-08-05 2006-12-05 Glaxo Group Limited Compounds useful in the manufacture of an anti-inflammatory androstane derivative
US7629335B2 (en) 2000-08-05 2009-12-08 Glaxo Group Limited Anti-inflammatory androstane derivative
US7541350B2 (en) 2000-08-05 2009-06-02 Glaxo Group Limited Formulation containing anti-inflammatory androstane derivative
US7531528B2 (en) 2000-08-05 2009-05-12 Glaxo Group Limited Formulation containing anti-inflammatory androstane derivatives
US7291608B2 (en) 2001-04-30 2007-11-06 Glaxo Group Limited Anti-inflammatory 17.β.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.α
CN1302007C (zh) * 2001-04-30 2007-02-28 葛兰素集团有限公司 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.－硫代羧酸酯衍生物
KR100831534B1 (ko) * 2001-04-30 2008-05-22 글락소 그룹 리미티드 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
WO2002088167A1 (en) * 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
US7592329B2 (en) 2002-02-04 2009-09-22 Glaxo Group Limited Crystalline complexes of fluticasone-2-furoate
US8168620B2 (en) 2002-06-14 2012-05-01 Cipla Limited Combination of azelastine and steroids
US8163723B2 (en) 2002-06-14 2012-04-24 Cipla Limited Combination of azelastine and steroids
US8304405B2 (en) 2002-06-14 2012-11-06 Cipla Limited Combination of azelastine and ciclesonide for nasal administration
US8318709B2 (en) 2002-06-14 2012-11-27 Cipla Limited Combination of azelastine and mometasone for nasal administration
US9901585B2 (en) 2002-06-14 2018-02-27 Cipla Limited Combination of azelastine and fluticasone for nasal administration
WO2007099548A3 (en) * 2006-01-27 2008-10-09 Sun Pharmaceutical Ind Ltd Novel 11 beta - hydroxyandrosta-4-ene-3-ones
AP2642A (en) * 2006-01-27 2013-04-15 Sun Pharma Advanced Res Co Ltd Novel 11 beta-hydroxyandrosta-4-ene-3-ones
WO2018232007A1 (en) 2017-06-13 2018-12-20 Bodor Laboratories, Inc. Potent soft anti-inflammatory corticosteroid compounds and uses therof
US11447522B2 (en) 2017-06-13 2022-09-20 Bodor Laboratories, Inc. Potent soft anti-inflammatory corticosteroid compounds and uses thereof

Also Published As

Publication number Publication date
ZA814440B (en) 1982-10-27
JPS6411037B2 (nl) 1989-02-23
SU1318169A3 (ru) 1987-06-15
JPS5745200A (en) 1982-03-13

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: BODOR NICHOLAS STEPHEN

Effective date: 20010709