BE837073A - Nouveau procede de preparation de composes bis-indoliques - Google Patents

Nouveau procede de preparation de composes bis-indoliques

Info

Publication number
BE837073A
BE837073A BE163109A BE163109A BE837073A BE 837073 A BE837073 A BE 837073A BE 163109 A BE163109 A BE 163109A BE 163109 A BE163109 A BE 163109A BE 837073 A BE837073 A BE 837073A
Authority
BE
Belgium
Prior art keywords
bis
preparation
new process
indolic compounds
indolic
Prior art date
Application number
BE163109A
Other languages
English (en)
French (fr)
Inventor
P Potier
N Langlois
Y Langlois
F Gueritte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9146736&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE837073(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of BE837073A publication Critical patent/BE837073A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
BE163109A 1974-12-30 1975-12-24 Nouveau procede de preparation de composes bis-indoliques BE837073A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7443221A FR2296418B1 (nl) 1974-12-30 1974-12-30

Publications (1)

Publication Number Publication Date
BE837073A true BE837073A (fr) 1976-06-24

Family

ID=9146736

Family Applications (1)

Application Number Title Priority Date Filing Date
BE163109A BE837073A (fr) 1974-12-30 1975-12-24 Nouveau procede de preparation de composes bis-indoliques

Country Status (10)

Country Link
US (2) US4769453A (nl)
JP (1) JPS6056719B2 (nl)
BE (1) BE837073A (nl)
CA (1) CA1132544A (nl)
CH (1) CH606023A5 (nl)
DE (1) DE2558124A1 (nl)
FR (1) FR2296418B1 (nl)
GB (1) GB1536407A (nl)
HU (1) HU177154B (nl)
NL (1) NL184418C (nl)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2296418B1 (nl) * 1974-12-30 1978-07-21 Anvar
IL53813A (en) * 1977-01-19 1982-07-30 Lilly Co Eli 4'-deoxyvincristine and related compounds,their preparation and antitumor pharmaceutical compositions containing them
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
HU180924B (en) 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4191688A (en) 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4195022A (en) 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
FR2443470A1 (fr) * 1978-12-08 1980-07-04 Anvar Nouveau procede de synthese de la vinblastine et de la leurosidine
JPS62502684A (ja) * 1985-03-12 1987-10-15 ザ・ユニバ−シテイ・オブ・バ−モント・アンド・ステイト・アグリカルチユラル・カレツジ ビンブラスチン及びビンクリスチン型化合物の合成
US4897477A (en) * 1985-03-12 1990-01-30 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4841045A (en) * 1985-03-12 1989-06-20 University Of Vermont & State Agricultural College Synthesis of vinblastine and vincristine type compounds
US4778885A (en) * 1986-09-18 1988-10-18 Allelix Inc. Production of alkaloid dimers using ferric ion
CA1341261C (en) * 1987-01-22 2001-06-26 James P. Kutney Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
AU1066888A (en) * 1987-01-22 1988-08-04 University Of British Columbia, The Process for the synthesis of vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5037977A (en) * 1988-08-11 1991-08-06 Mitsui Petrochemical Industries Ltd. Method for production of dimeric alkaloids
FR2707988B1 (fr) * 1993-07-21 1995-10-13 Pf Medicament Nouveaux dérivés antimitotiques des alcaloïdes binaires du catharantus rosesus, leur procédé de préparation et les compositions pharmaceutiques les comprenant.
WO1997005869A1 (en) * 1995-08-08 1997-02-20 Albany Medical College Ibogamine congeners
FR2779146B1 (fr) 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7235564B2 (en) * 2003-12-04 2007-06-26 Amr Technology, Inc. Vinorelbine derivatives
JP5448299B2 (ja) * 2003-12-04 2014-03-19 アルバニー モレキュラー リサーチ， インコーポレイテッド ビンカ誘導体
WO2008033930A2 (en) * 2006-09-12 2008-03-20 Amr Technology, Inc. Vinca derivatives
US20080125451A1 (en) * 2006-09-12 2008-05-29 Amr Technology, Inc. Vinorelbine derivatives
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
WO2012012764A1 (en) 2010-07-23 2012-01-26 Demerx, Inc. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US8742096B2 (en) * 2011-03-28 2014-06-03 Demerx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
CA2855994A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
EP2807168A4 (en) 2012-01-25 2015-10-14 Demerx Inc SYNTHETIC VOACANGINE
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
WO2014098877A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH77A (de) * 1889-01-09 Christian Herren Wurzelschneidmaschine
FR2210393B1 (nl) * 1972-12-19 1976-07-02 Richter Gedeon Vegyeszet
HU165986B (nl) * 1973-02-16 1974-12-28
FR2296418B1 (nl) * 1974-12-30 1978-07-21 Anvar
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
US4029663A (en) * 1975-07-10 1977-06-14 Eli Lilly And Company Dimeric anhydro-vinca derivatives
US4143041A (en) * 1977-01-19 1979-03-06 Eli Lilly And Company 4'-Deoxyvincristine and related compounds
HU180924B (en) * 1977-05-20 1983-05-30 Richter Gedeon Vegyeszet Process for producing leurosine-type alkaloides
HU178084B (en) * 1977-05-31 1982-03-28 Richter Gedeon Vegyeszet New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue

Also Published As

Publication number Publication date
NL7515193A (nl) 1976-07-02
HU177154B (en) 1981-08-28
DE2558124A1 (de) 1976-07-01
US4769453A (en) 1988-09-06
NL184418B (nl) 1989-02-16
JPS6056719B2 (ja) 1985-12-11
JPS5188999A (en) 1976-08-04
CA1132544A (en) 1982-09-28
US4737586A (en) 1988-04-12
CH606023A5 (nl) 1978-10-13
NL184418C (nl) 1989-07-17
DE2558124C2 (nl) 1991-04-18
FR2296418A1 (nl) 1976-07-30
FR2296418B1 (nl) 1978-07-21
GB1536407A (en) 1978-12-20

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Effective date: 19951224