BE799611A - Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation - Google Patents

Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation

Info

Publication number
BE799611A
BE799611A BE131180A BE131180A BE799611A BE 799611 A BE799611 A BE 799611A BE 131180 A BE131180 A BE 131180A BE 131180 A BE131180 A BE 131180A BE 799611 A BE799611 A BE 799611A
Authority
BE
Belgium
Prior art keywords
new
preparation process
amino benzoyl
phenylacetic acids
phenylacetic
Prior art date
Application number
BE131180A
Other languages
English (en)
French (fr)
Inventor
W J Welstead
H W Moran
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of BE799611A publication Critical patent/BE799611A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE131180A 1975-08-13 1973-05-16 Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation BE799611A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/604,371 US4045576A (en) 1975-08-13 1975-08-13 Anti-inflammatory methods using 2-amino-3-(5- and 6-)benzoylphenylacetic acids, esters and metal salts thereof and the compounds

Publications (1)

Publication Number Publication Date
BE799611A true BE799611A (fr) 1973-09-17

Family

ID=24419335

Family Applications (2)

Application Number Title Priority Date Filing Date
BE131180A BE799611A (fr) 1975-08-13 1973-05-16 Nouveaux acides amino-2 benzoyl-3(et-5) phenylacetiques et leur procede de preparation
BE163180A BE837154A (fr) 1975-08-13 1975-12-29 Acides 2-amino-3-(5- et 6-)- benzoyl - phenylacetiques, leurs esters et leurs sels metalliques

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE163180A BE837154A (fr) 1975-08-13 1975-12-29 Acides 2-amino-3-(5- et 6-)- benzoyl - phenylacetiques, leurs esters et leurs sels metalliques

Country Status (15)

Country Link
US (3) US4045576A (it)
JP (3) JPS523381B2 (it)
AT (2) AT329542B (it)
AU (1) AU530940B2 (it)
BE (2) BE799611A (it)
CA (2) CA1012979A (it)
CH (1) CH577461A5 (it)
DE (2) DE2324768C2 (it)
ES (1) ES446625A1 (it)
FR (1) FR2184934B1 (it)
GB (2) GB1432576A (it)
MX (1) MX4035E (it)
NL (1) NL183722C (it)
PH (2) PH12656A (it)
SE (1) SE400966B (it)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH577461A5 (it) * 1975-08-13 1976-07-15 Robins Co Inc A H
FR2366015A1 (fr) * 1975-11-05 1978-04-28 Robins Co Inc A H Nouveaux acides amino-2 benzoyl-3 (5 et 6) phenylacetiques et leurs esters et sels de metaux alcalins, utiles notamment comme anti-inflammatoires, et leur procede de preparation
US4221716A (en) * 1979-02-16 1980-09-09 A. H. Robins Company, Inc. Intermediate and process for the preparation of 7-acylindolin-2-ones
EP0089426B1 (en) * 1979-07-12 1986-06-11 A.H. Robins Company, Incorporated 2-amino-6-biphenylacetic acids
IL60444A (en) * 1979-08-01 1985-03-31 Robins Co Inc A H 2-amino-3-(alkylthiobenzoyl)-phenylacetic acid derivatives and pharmaceutical compositions containing them
US4313949A (en) * 1979-09-26 1982-02-02 A. H. Robins Company, Inc. Method of producing an inhibitory effect on blood platelet aggregation
ZA805476B (en) * 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
US4254146A (en) * 1979-10-18 1981-03-03 A. H. Robins Company, Inc. 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them
US4503073A (en) * 1981-01-07 1985-03-05 A. H. Robins Company, Incorporated 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids
IL64724A0 (en) * 1981-02-17 1982-03-31 Robins Co Inc A H 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them
JPS6019753A (ja) * 1983-07-13 1985-01-31 Shionogi & Co Ltd オルト−（モノ置換アミノ）フエニルイミン類およびその製造法
JPS6026586U (ja) * 1983-07-29 1985-02-22 日本軽金属株式会社 改装サッシ窓における隙間閉塞装置
SE8400239D0 (sv) * 1984-01-19 1984-01-19 Pharmacia Ab Nya arylettiksyraderivat
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US4782089A (en) * 1986-08-26 1988-11-01 A. H. Robins Company, Incorporated 2-amino-3-aroyl-gamma-oxobenzenebutanoic acids and esters
US4880788A (en) * 1987-10-30 1989-11-14 Baylor College Of Medicine Method for preventing and treating thrombosis
CA1325382C (en) * 1988-01-27 1993-12-21 Takahiro Ogawa Locally administrable therapeutic composition for inflammatory disease
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
AU659106B2 (en) * 1990-11-06 1995-05-11 Fgn, Inc. Method for treating colonic polyps by the use of esters and amides of substituted phenyl and pyridyl amino carboxylates
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
EP0990637A4 (en) * 1997-04-28 2003-01-02 Medical Information Services I PROCESS FOR PREPARING KETOPROFENE AND 5-BENZOYLE-3-METHYLE-2-INDOLINONE
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AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
US6692772B2 (en) * 2001-07-18 2004-02-17 Cedars-Sinai Medical Center Prevention of in-stent thrombosis and complications after arterial angioplasty with stent placement using magnesium
KR20040101499A (ko) * 2002-05-03 2004-12-02 알콘, 인코퍼레이티드 암페낙 또는 네파페낙을 이용한 혈관 내피 성장 인자 매개혈관 장애 치료 방법
ATE393627T1 (de) 2003-01-21 2008-05-15 Senju Pharma Co Wässrige flüssige zubereitung mit 2-amino-3-(4- bromobenzoyl)phenylessigsäure
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JP5460324B2 (ja) * 2006-10-12 2014-04-02 ゼノン・ファーマシューティカルズ・インコーポレイテッド 治療剤としてのスピロ−オキシインドール化合物の使用
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US20080153818A1 (en) * 2006-12-21 2008-06-26 Bingaman David P Methods for preventing inflammation during surgery
US20090105245A1 (en) * 2006-12-21 2009-04-23 Bingaman David P Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor
US20090076150A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched bromfenac
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CN104974057B (zh) * 2014-04-08 2018-05-18 天津金耀集团有限公司 一种溴芬酸钠的制备方法和重要中间体
CN104151182B (zh) * 2014-06-16 2016-03-30 广东众生药业股份有限公司 一种溴芬酸钠倍半水合物的制备方法
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CN104693019B (zh) * 2015-02-06 2017-02-01 宁波九胜创新医药科技有限公司 一种2,5‑二溴苯乙酸的制备方法
CN106278918B (zh) * 2016-08-12 2018-05-11 合肥久诺医药科技有限公司 一种溴芬酸钠杂质标准品2-氨基-3-(4-溴苯甲酰基)苯甲酸的合成方法
CN106278917B (zh) * 2016-08-12 2018-05-08 合肥久诺医药科技有限公司 一种溴芬酸钠降解杂质标准品的合成方法
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GB1226344A (it) * 1967-07-31 1971-03-24
US3899529A (en) * 1973-02-22 1975-08-12 Merck & Co Inc Aroyl substituted naphthalene acetic acids
CH577461A5 (it) * 1975-08-13 1976-07-15 Robins Co Inc A H

Also Published As

Publication number Publication date
JPS523381B2 (it) 1977-01-27
AU6181480A (en) 1981-01-08
JPS4941349A (it) 1974-04-18
GB1521097A (en) 1978-08-09
DE2324768C2 (de) 1985-08-14
DE2636582A1 (de) 1977-02-24
SE400966B (sv) 1978-04-17
AT329542B (de) 1976-05-10
ES446625A1 (es) 1977-06-01
DE2324768A1 (de) 1973-11-29
AU530940B2 (en) 1983-08-04
NL7306833A (it) 1973-11-20
JPS5726585B2 (it) 1982-06-05
US4182774A (en) 1980-01-08
ATA429873A (de) 1975-08-15
CA1087205A (en) 1980-10-07
NL183722B (nl) 1988-08-01
NL183722C (nl) 1989-01-02
FR2184934B1 (it) 1976-11-05
CA1012979A (en) 1977-06-28
JPS5223052A (en) 1977-02-21
BE837154A (fr) 1976-04-16
PH12656A (en) 1979-07-11
PH15112A (en) 1982-08-10
FR2184934A1 (it) 1973-12-28
US4045576A (en) 1977-08-30
DE2636582C2 (de) 1986-03-27
AT347433B (de) 1978-12-27
US4126635A (en) 1978-11-21
AU5584673A (en) 1974-11-21
ATA977475A (de) 1978-05-15
GB1432576A (en) 1976-04-22
CH577461A5 (it) 1976-07-15
JPS55349A (en) 1980-01-05
MX4035E (es) 1981-11-18

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: A.H. ROBINS CY INC. (ETAT DE DELAWARE)

Effective date: 19930516