BE792533A - Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation - Google Patents

Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation

Info

Publication number
BE792533A
BE792533A BE792533DA BE792533A BE 792533 A BE792533 A BE 792533A BE 792533D A BE792533D A BE 792533DA BE 792533 A BE792533 A BE 792533A
Authority
BE
Belgium
Prior art keywords
pyrimidines
preparation process
new pyrazolo
pyrazolo
new
Prior art date
Application number
Other languages
English (en)
French (fr)
Inventor
Der K Robins
D E O'brien
T Novinson
R K Robins
R H Springer
Original Assignee
Int Chem & Nuclear Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Priority claimed from US245870A external-priority patent/US3925385A/en
Publication of BE792533A publication Critical patent/BE792533A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE792533D 1971-12-09 Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation BE792533A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20653871A 1971-12-09 1971-12-09
US245870A US3925385A (en) 1972-04-20 1972-04-20 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US27346572A 1972-07-20 1972-07-20
US29984072A 1972-10-24 1972-10-24

Publications (1)

Publication Number Publication Date
BE792533A true BE792533A (fr) 1973-06-08

Family

ID=27498614

Family Applications (1)

Application Number Title Priority Date Filing Date
BE792533D BE792533A (fr) 1971-12-09 Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation

Country Status (15)

Country Link
JP (1) JPS4864097A (en:Method)
BE (1) BE792533A (en:Method)
BG (1) BG22401A3 (en:Method)
CH (1) CH603652A5 (en:Method)
DD (1) DD104530A5 (en:Method)
DE (1) DE2257547A1 (en:Method)
GB (1) GB1412017A (en:Method)
HU (1) HU168530B (en:Method)
IE (1) IE37189B1 (en:Method)
IL (1) IL40895A (en:Method)
LU (1) LU66597A1 (en:Method)
NL (1) NL7216539A (en:Method)
NO (1) NO137012C (en:Method)
RO (1) RO62762A (en:Method)
SE (1) SE398751B (en:Method)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE3533050A1 (de) * 1985-09-17 1987-03-26 Basf Ag 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide
CA1330079C (en) * 1988-10-13 1994-06-07 Michihiko Tsujitani Pyrrolo (3,2-e)pyrazolo(1,5-a)pyrimidine derivative and medicine comprising the same
ES2126573T3 (es) * 1991-04-22 1999-04-01 Otsuka Pharma Co Ltd Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
EP0714898B1 (en) * 1994-06-21 2001-11-14 Otsuka Pharmaceutical Factory, Inc. PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE
CN1169149A (zh) * 1995-09-28 1997-12-31 株式会社大制药工场 止痛组合物
FR2771631B1 (fr) 1997-12-03 2001-02-02 Oreal Compositions de teinture des fibres keratiniques contenant des 3-amino pyrazolo-[1,5-a]-pyrimidines, procede de teinture, nouvelles 3-amino pyrazolo- [1,5-a]-pyrimidines et leur procede de preparation
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
AU2003263071B2 (en) * 2002-09-04 2007-03-15 Merck Sharp & Dohme Llc Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
EP2989106B1 (en) 2013-04-25 2016-12-14 Beigene, Ltd. Fused heterocyclic compounds as protein kinase inhibitors
AU2013400609B9 (en) 2013-09-13 2020-03-05 Beigene Switzerland Gmbh Anti-PD1 antibodies and their use as therapeutics and diagnostics
TWI726608B (zh) 2014-07-03 2021-05-01 英屬開曼群島商百濟神州有限公司 抗pd-l1抗體及其作為治療及診斷之用途
CN109475536B (zh) 2016-07-05 2022-05-27 百济神州有限公司 用于治疗癌症的PD-l拮抗剂和RAF抑制剂的组合
EA201990519A1 (ru) 2016-08-16 2019-08-30 Бейджин, Лтд. КРИСТАЛЛИЧЕСКАЯ ФОРМА (S)-7-(1-АКРИЛОИЛПИПЕРИДИН-4-ИЛ)-2-(4-ФЕНОКСИФЕНИЛ)-4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-a]ПИРИМИДИН-3-КАРБОКСАМИДА, ЕЕ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЯ
EP3500299B1 (en) 2016-08-19 2023-12-13 BeiGene Switzerland GmbH Combination of zanubrutinib with an anti-cd20 or an anti-pd-1 antibody for use in treating cancer
CN110461847B (zh) 2017-01-25 2022-06-07 百济神州有限公司 (S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途
EP3645569A4 (en) 2017-06-26 2021-03-24 BeiGene, Ltd. IMMUNOTHERAPY FOR LIVER CELL CARCINOMA
WO2019034009A1 (en) 2017-08-12 2019-02-21 Beigene, Ltd. BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
CN111801334B (zh) 2017-11-29 2023-06-09 百济神州瑞士有限责任公司 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤
JP2022538214A (ja) 2019-06-10 2022-09-01 ベイジーン スウィッツァーランド ゲーエムベーハー ブルトン型チロシンキナーゼ阻害剤を含む経口固体錠剤及びその調製方法
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Also Published As

Publication number Publication date
DD104530A5 (en:Method) 1974-03-12
HU168530B (en:Method) 1976-05-28
JPS4864097A (en:Method) 1973-09-05
IE37189L (en) 1973-06-09
IE37189B1 (en) 1977-05-25
SE398751B (sv) 1978-01-16
IL40895A0 (en) 1973-01-30
DE2257547A1 (de) 1973-06-14
CH603652A5 (en:Method) 1978-08-31
NL7216539A (en:Method) 1973-06-13
IL40895A (en) 1976-12-31
RO62762A (fr) 1978-05-15
LU66597A1 (en:Method) 1973-03-15
BG22401A3 (bg) 1977-02-20
GB1412017A (en) 1975-10-29
NO137012C (no) 1977-12-14
NO137012B (no) 1977-09-05

Similar Documents

Publication Publication Date Title
BE792533A (fr) Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
BE783044A (fr) Nouvelles thieno(3,2-d) pyrimidines
CH555308A (fr) Procede de preparation de 2,3,5-trimethylhydroquinone.
BE784259A (fr) Aryl-guanidines ortho-disubstituees, leur procede de preparation et leurs applications
BE804580A (fr) Derives de l'alpha-phenylindole, leur procede de fabrication et leur utilisation
CH547324A (fr) Procede de preparation de polyamides et leur utilisation.
BE809011A (fr) Organopolysiloxanes fluores, leur procede de preparation et leur utilisation
FR2319341A1 (fr) Nouvelles guanidines ou thiourees, leur procede de preparation et leur application
CH547325A (fr) Procede de preparation de polyamides et leur utilisation.
BE788240A (fr) Teintures, leur procede de preparation et leur application
BE763077A (fr) Bis-(hydroxyaryl)-1,3 tetraorganodisiloxanes et leur procede depreparation.
CH547326A (fr) Procede de preparation de polyamides et leur utilisation.
BE795525A (fr) Naphtopyrannes, leur procede de preparation et leur applications
BE791242A (fr) Nouvelles thiazolo(5,4-d)pyrimidines
CH550813A (fr) Procede de preparation de pyrazolo(3,4-b)pyridine-5-carboxamides.
BE777062A (fr) 3-sulfo-alkyl-6-hydroxy-pyridones-(2), leur procede de preparation et application
BE751562A (fr) 4-pyrazolidinols 1,2-disubstitues et leur procede de preparation
BE802328A (fr) Cyanophenoxyacetonitriles, leur procede de preparation et leur utilisation
BE790056A (fr) Procede de preparation de 1, 1'-dianthraquinonyles
BE806089A (fr) 2,10-dichloro-12-methyl-12h-dibenzo (d.g.) (1,3) dioxocines, leur procede de preparation et leurs applications
BE782182A (fr) Nouvelles 1,2,3,4-tetrahydroisoquinoleines et leur procede de preparation
BE818908A (fr) 1,3,4-thiadiazol-2-yl-urees herbicides et leur procede de preparation
BE793131A (fr) 2-alcoyl-2-mecaptomethylpropane diols-1,3 et procede de preparation
BE785023A (fr) Nouvelles 4h-s-triazolo(4,3-a)(1,4) benzodiazepines disubstituees en positions 1,6 et leur procede de preparation
BE782851A (fr) Pyrimidines 2,5-bis-substituees et leur preparation