BE789948A - Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Info

Publication number
BE789948A
BE789948A BE789948DA BE789948A BE 789948 A BE789948 A BE 789948A BE 789948D A BE789948D A BE 789948DA BE 789948 A BE789948 A BE 789948A
Authority
BE
Belgium
Prior art keywords
pyrazole
preparation
application
medicinal products
new derivatives
Prior art date
Application number
Other languages
English (en)
French (fr)
Inventor
D A Habeck
W J Houlihan
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Publication of BE789948A publication Critical patent/BE789948A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE789948D 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments BE789948A (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18893871A 1971-10-13 1971-10-13
US23138772A 1972-03-02 1972-03-02
US25985972A 1972-06-05 1972-06-05
US27486872A 1972-07-25 1972-07-25
US30259572A 1972-10-31 1972-10-31
US34139273A 1973-03-15 1973-03-15
US05/350,140 US3932430A (en) 1971-10-13 1973-04-11 Substituted indeno, naphtho and cyclohepta pyrazoles

Publications (1)

Publication Number Publication Date
BE789948A true BE789948A (fr) 1973-04-11

Family

ID=27569229

Family Applications (3)

Application Number Title Priority Date Filing Date
BE789948D BE789948A (fr) 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE129814A BE797964R (fr) 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Family Applications After (2)

Application Number Title Priority Date Filing Date
BE129814A BE797964R (fr) 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Country Status (6)

Country Link
US (1) US3932430A (xx)
AU (1) AU4765672A (xx)
BE (3) BE797964R (xx)
DE (2) DE2249644A1 (xx)
FR (1) FR2157852A1 (xx)
NL (2) NL7213549A (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969527A (en) * 1975-07-28 1976-07-13 E. R. Squibb & Sons, Inc. CNS active compounds
US4173634A (en) * 1979-02-23 1979-11-06 E. R. Squibb & Sons, Inc. Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents
JPH04504126A (ja) * 1989-03-09 1992-07-23 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 殺節足動物性テトラヒドロベンゾピラノピラゾール
WO1994010162A1 (en) * 1992-10-23 1994-05-11 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
AU7553198A (en) * 1997-06-12 1998-12-30 Sumitomo Pharmaceuticals Company, Limited Pyrazole derivatives
CN1278724A (zh) * 1997-10-06 2001-01-03 巴斯福股份公司 抑制酪氨酸激酶活性的茚并[1,2－c]吡唑衍生物
JP2001518501A (ja) 1997-10-06 2001-10-16 ビーエーエスエフ アクチェンゲゼルシャフト インデノ［１，２−ｃ］−、ナフト［１，２−ｃ］−およびベンゾ［６，７］シクロへプタ［１，２−ｃ］ピラゾール誘導体
DE69918542T2 (de) * 1998-04-30 2005-08-18 Abbott Gmbh & Co. Kg Substituierte trizyklische pyrazolderivate mit protein kinase aktivität
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
BR9915139A (pt) * 1998-11-06 2001-08-07 Basf Ag Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo
US6297238B1 (en) 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
ATE402699T1 (de) * 2000-09-06 2008-08-15 Ortho Mcneil Pharm Inc Verwendung von substituierten pyrazolen zur behandlung von allergien
CA2424555A1 (en) * 2000-10-02 2002-04-11 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
US7320986B2 (en) * 2003-03-07 2008-01-22 Abbott Labortories Fused tri and tetra-cyclic pyrazole kinase inhibitors
CA2517885A1 (en) * 2003-03-07 2004-09-23 Abbott Laboratories Fused tri and tetra-cyclic pyrazole kinase inhibitors
AU2004315596B2 (en) * 2003-08-29 2011-11-24 President And Fellows Of Harvard College Inhibitors of cellular necrosis
EP1815206B1 (en) 2004-10-13 2016-04-06 PTC Therapeutics, Inc. Compounds for nonsense suppression, and methods for their use
KR101107800B1 (ko) * 2006-10-31 2012-01-25 화이자 프로덕츠 인코포레이티드 무기질코르티코이드 수용체 길항제로서의 피라졸린 화합물
WO2009089285A2 (en) * 2008-01-07 2009-07-16 Emory University Branched diepoxide compounds for the treatment of inflammatory disorders
EP2381775A4 (en) 2008-12-23 2012-08-15 Harvard College INHIBITORS OF NECROPTOSIS OF SMALL MOLECULAR SIZE
EP2968276A4 (en) 2013-03-15 2017-02-15 President and Fellows of Harvard College Hybrid necroptosis inhibitors
BR112016000869B1 (pt) * 2013-07-15 2021-07-06 Basf Se composto, composição agrícola, composição veterinária e usos de um composto
WO2016094846A1 (en) 2014-12-11 2016-06-16 President And Fellows Of Harvard College Inhibitors of cellular necrosis and related methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816438A (en) * 1972-12-22 1974-06-11 Sandoz Ag 2h(1)-benzothiepino(5,4-c)-pyrazoles and(1)-benzothiopyrano(4,3-c)-pyrazoles
US3843664A (en) * 1973-02-20 1974-10-22 Sandoz Ag Substituted naphtho pyrazoles

Also Published As

Publication number Publication date
FR2157852A1 (xx) 1973-06-08
NL7304722A (xx) 1974-05-02
US3932430A (en) 1976-01-13
DE2317716A1 (de) 1974-05-02
BE797964R (fr) 1973-10-09
NL7213549A (xx) 1973-04-17
DE2249644A1 (de) 1973-04-19
BE806671R (fr) 1974-04-29
AU4765672A (en) 1974-04-26

Similar Documents

Publication Publication Date Title
BE806671R (fr) Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE799332A (fr) Nouveaux derives du benzothiadiazole, leur preparation et leur application comme medicaments
BE783219A (fr) Nouveaux composes heterocycliques, leur preparation et leur applicationcomme medicaments
BE791699A (fr) Nouveaux derives du thioxanthene, leur preparation et leur application comme medicaments
BE785937A (fr) Nouveaux derives de la quinazoline, leur preparation et leur application comme medicaments
BE792078A (fr) Nouveaux derives de l'indazole, leur preparation et leur application comme medicaments
BE783625A (fr) Nouveaux derives de l'ergolene, leur preparation et leur application comme medicaments
BE787235A (fr) Nouveaux derives du thiophene, leur preparation et leur application comme medicaments
BE790604A (fr) Nouveaux aminoalcanols, leur preparation et leur application comme medicaments
BE787804A (fr) Nouveaux composes spiranniques, leur preparation et leur application comme medicaments
BE825643A (fr) Nouveaux derives du biphenyle, leur preparation et leur application comme medicaments
BE788476A (fr) Nouveaux derives de la pyridazinone, leur preparation et leur application comme medicaments
BE787059A (fr) Nouveaux derives du thiazole, leur preparation et leur application comme medicaments
BE792515A (fr) Nouveaux derives de l'acide lysergique, leur preparation et leur application comme medicaments
BE776315A (fr) Nouveaux derives de la 1-amino-isoquinoleine, leur preparation et leur application comme medicaments
BE779586A (fr) Nouveaux derives de la p-phenylene-diamine, leur preparation etleur application comme medicaments
BE781013A (fr) Nouveaux derives de la quinoleine, leur preparation et leur applicationcomme medicaments
BE779402A (fr) Nouveaux derives du 2-amino-propanol, leur preparation et leur application comme medicaments
FR2314715A1 (fr) Nouveaux derives du benzo-cyclohepta-thiophene, leur preparation et leur application comme medicaments
FR2323386A1 (fr) Nouveaux derives de la benzo-cyclohepta-pyridine, leur preparation et leur application comme medicaments
FR2320103A1 (fr) Nouveaux derives de la morphanthridine, leur preparation et leur application comme medicaments
BE820943A (fr) Nouveaux derives du benzo-cyclophepta-thiophene leur preparation et leur application comme medicaments
BE791098A (fr) Nouveaux derives de la pyridazine, leur preparation et leur applicationcomme medicaments
BE806526A (fr) Nouveaux derives de l'imidazo-quinazoline, leur preparation et leur application comme medicaments
BE828548A (fr) Nouveaux derives de la as-triazine, leur preparation et leur application comme medicaments