BE797964R - Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments - Google Patents

Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Info

Publication number
BE797964R
BE797964R BE129814A BE129814A BE797964R BE 797964 R BE797964 R BE 797964R BE 129814 A BE129814 A BE 129814A BE 129814 A BE129814 A BE 129814A BE 797964 R BE797964 R BE 797964R
Authority
BE
Belgium
Prior art keywords
pyrazole
preparation
application
medicinal products
new derivatives
Prior art date
Application number
BE129814A
Other languages
English (en)
Inventor
D A Habeck
W J Houlihan
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE797964R publication Critical patent/BE797964R/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE129814A 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments BE797964R (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18893871A 1971-10-13 1971-10-13
US23138772A 1972-03-02 1972-03-02
US25985972A 1972-06-05 1972-06-05
US27486872A 1972-07-25 1972-07-25
US30259572A 1972-10-31 1972-10-31
US34139273A 1973-03-15 1973-03-15
US05/350,140 US3932430A (en) 1971-10-13 1973-04-11 Substituted indeno, naphtho and cyclohepta pyrazoles

Publications (1)

Publication Number Publication Date
BE797964R true BE797964R (fr) 1973-10-09

Family

ID=27569229

Family Applications (3)

Application Number Title Priority Date Filing Date
BE789948D BE789948A (fr) 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE129814A BE797964R (fr) 1971-10-13 1973-04-09 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE789948D BE789948A (fr) 1971-10-13 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
BE137196A BE806671R (fr) 1971-10-13 1973-10-29 Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments

Country Status (6)

Country Link
US (1) US3932430A (fr)
AU (1) AU4765672A (fr)
BE (3) BE797964R (fr)
DE (2) DE2249644A1 (fr)
FR (1) FR2157852A1 (fr)
NL (2) NL7213549A (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3969527A (en) * 1975-07-28 1976-07-13 E. R. Squibb & Sons, Inc. CNS active compounds
US4173634A (en) * 1979-02-23 1979-11-06 E. R. Squibb & Sons, Inc. Basically-substituted tricyclic pyrazoles useful as antiinflammatory agents
EP0386892A3 (fr) * 1989-03-09 1990-11-28 E.I. Du Pont De Nemours And Company Tetrahydrobenzopyranopyrazoles comme arthropodicides
US5670522A (en) * 1992-10-23 1997-09-23 Merck Sharp & Dohme Limited Dopamine receptor subtype ligands
TW403738B (en) * 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives
AU7553198A (en) * 1997-06-12 1998-12-30 Sumitomo Pharmaceuticals Company, Limited Pyrazole derivatives
CN1278725A (zh) 1997-10-06 2001-01-03 巴斯福股份公司 茚并[1,2－c]－、萘并[1,2－c]－和苯并[6,7]芳庚并[1,2－c]吡唑类衍生物
EP1021182A1 (fr) * 1997-10-06 2000-07-26 Basf Aktiengesellschaft Derives d'indeno 1,2-c]pyrazole utiles pour inhiber l'activite de tyrosine kinase
WO1999055335A1 (fr) * 1998-04-30 1999-11-04 Basf Aktiengesellschaft Derives substitues de pyrazole tricyclique exerçant une activite de proteine kinase
JP2002529421A (ja) * 1998-11-06 2002-09-10 ビーエーエスエフ アクチェンゲゼルシャフト 血管過浸透性の阻害方法
US6462036B1 (en) * 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
US6297238B1 (en) 1999-04-06 2001-10-02 Basf Aktiengesellschaft Therapeutic agents
AU8873101A (en) * 2000-09-06 2002-03-22 Ortho Mcneil Pharm Inc A method for treating allergies using substituted pyrazoles
EP1330459B1 (fr) * 2000-10-02 2006-08-02 Emory University Analogues de triptolides destines au traitement des troubles autoimmuns et inflammatoires
US7320986B2 (en) * 2003-03-07 2008-01-22 Abbott Labortories Fused tri and tetra-cyclic pyrazole kinase inhibitors
JP2006520400A (ja) * 2003-03-07 2006-09-07 アボット・ラボラトリーズ 縮合三および四環式ピラゾールキナーゼ阻害剤
PL2384753T3 (pl) * 2003-08-29 2016-09-30 Pochodne hydantoiny jako inhibitory martwicy komórkowej
EP1812071A2 (fr) 2004-10-13 2007-08-01 PTC Therapeutics, Inc. Les composes pour la suppression de non-sens et l'emploi de ces composes pour la production d'un medicament pour le traitement des maladies somatiques causes par les mutations
EA016370B1 (ru) * 2006-10-31 2012-04-30 Пфайзер Продактс Инк. Пиразолиновые соединения в качестве антагонистов минералокортикоидных рецепторов
WO2009089285A2 (fr) * 2008-01-07 2009-07-16 Emory University Composés diépoxydes ramifiés pour le traitement de troubles inflammatoires
CA2772760A1 (fr) 2008-12-23 2010-07-01 President And Fellows Of Harvard College Inhibiteurs de la necroptose de petite taille moleculaire
US20160024098A1 (en) 2013-03-15 2016-01-28 President And Fellows Of Harvard College Hybrid necroptosis inhibitors
JP2016529234A (ja) * 2013-07-15 2016-09-23 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 殺有害生物化合物
CA2970525A1 (fr) 2014-12-11 2016-06-16 President And Fellows Of Harvard College Inhibiteurs de necrose cellulaire et procedes associes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3816438A (en) * 1972-12-22 1974-06-11 Sandoz Ag 2h(1)-benzothiepino(5,4-c)-pyrazoles and(1)-benzothiopyrano(4,3-c)-pyrazoles
US3843664A (en) * 1973-02-20 1974-10-22 Sandoz Ag Substituted naphtho pyrazoles

Also Published As

Publication number Publication date
DE2317716A1 (de) 1974-05-02
NL7213549A (fr) 1973-04-17
AU4765672A (en) 1974-04-26
FR2157852A1 (fr) 1973-06-08
US3932430A (en) 1976-01-13
BE789948A (fr) 1973-04-11
BE806671R (fr) 1974-04-29
DE2249644A1 (de) 1973-04-19
NL7304722A (fr) 1974-05-02

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