BE715545A - - Google Patents

Info

Publication number
BE715545A
BE715545A BE715545DA BE715545A BE 715545 A BE715545 A BE 715545A BE 715545D A BE715545D A BE 715545DA BE 715545 A BE715545 A BE 715545A
Authority
BE
Belgium
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BE715545A publication Critical patent/BE715545A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BE715545D 1963-10-17 1968-05-22 BE715545A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US317072A US3238215A (en) 1963-10-17 1963-10-17 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
GB00096/68A GB1218570A (en) 1963-10-17 1967-05-24 Indoles
GB2425667 1967-05-24

Publications (1)

Publication Number Publication Date
BE715545A true BE715545A (fr) 1968-11-22

Family

ID=27256462

Family Applications (1)

Application Number Title Priority Date Filing Date
BE715545D BE715545A (fr) 1963-10-17 1968-05-22

Country Status (10)

Country Link
US (2) US3238215A (fr)
BE (1) BE715545A (fr)
CH (5) CH553796A (fr)
DE (1) DE1770460C3 (fr)
FR (2) FR1582086A (fr)
GB (1) GB1218570A (fr)
IE (1) IE32083B1 (fr)
IN (1) IN115974B (fr)
MY (1) MY7100196A (fr)
NL (1) NL161359C (fr)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
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US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
BE665245A (fr) * 1964-06-11
US3412097A (en) * 1964-09-07 1968-11-19 Koninklijke Pharma Fab Nv Indole derivatives
US3462440A (en) * 1965-12-03 1969-08-19 American Home Prod 1,4-bis(2-indol-3-ylethyl)piperidines
US3984437A (en) * 1969-09-03 1976-10-05 Mitsubishi Chemical Industries Ltd. Basic dyestuff
SU516354A3 (ru) * 1970-03-07 1976-05-30 Краковски Заклады Фармацеутичне"Польфа" (Инопредприятие) Способ получени пиридиламидов фуранкарбоновой кислоты или их солей
US4028365A (en) * 1970-09-03 1977-06-07 John Wyeth & Brother Limited Benz[g]indolyl compounds
GB1374414A (en) * 1972-06-12 1974-11-20 Sterling Drug Inc 1-acyl-3-amino-alkyl-indoles and their preparation
US4160862A (en) * 1972-06-12 1979-07-10 Sterling Drug Inc. 1-Acyl-3-(amino-lower-alkyl)indoles
US4061758A (en) * 1972-06-30 1977-12-06 John Wyeth & Brother Limited Treating hypertension and central nervous system abnormalities
US4024147A (en) * 1972-06-30 1977-05-17 John Wyeth & Brother Limited Heterocyclic compounds
US3869463A (en) * 1973-01-17 1975-03-04 Wyeth John & Brother Ltd N-phenyl derivatives of alkanoylamido piperidines
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
GB1413708A (en) * 1973-06-19 1975-11-12 Wyeth John & Brother Ltd Indole derivative
US4061641A (en) * 1973-10-10 1977-12-06 John Wyeth & Brother Limited Ureidopiperidino-ketoalkyl indoles
US4177279A (en) * 1973-10-10 1979-12-04 John Wyeth & Brother Ltd. 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions
GB1459506A (en) * 1974-02-18 1976-12-22 Wyeth John & Brother Ltd Piperidine derivatives
US3936464A (en) * 1974-10-25 1976-02-03 American Cyanamid Company 1-Acyl-3-[2-(4-phenyl-1-piperidinyl)ethyl]indolines
US4026938A (en) * 1974-12-27 1977-05-31 Sterling Drug Inc. 1-Phenyl-3-azacarbocyclic-ureas
ZA76475B (en) * 1975-03-10 1977-08-31 Ciba Geigy Ag Indolyalkylpiperidines
GB1498884A (en) * 1975-04-15 1978-01-25 Wyeth John & Brother Ltd Aminoacetamide-pyridyl-tetrahydropyridyl and-piperidyl derivatives
US4147786A (en) * 1976-02-02 1979-04-03 Ciba-Geigy Corporation 1-Indolylalkyl-3-or 4-trimethyleneurido-piperidines
US4163789A (en) * 1976-02-17 1979-08-07 Anphar, S.A. Anti-psychotic (cycloalkenylalkylpiperidino) benzamides
GB1542137A (en) * 1976-03-12 1979-03-14 Wyeth John & Brother Ltd Process for preparing 3(piperidinoalkyl)indoles
GB1581620A (en) * 1977-02-23 1980-12-17 Sekisui Chemical Co Ltd Gas combustion system
EP0007399B1 (fr) 1978-06-24 1982-01-20 MERCK PATENT GmbH Indolylalcoylamines, préparations pharmaceutiques les contenant et procédé pour leur fabrication
US4242347A (en) * 1979-06-18 1980-12-30 Ciba-Geigy Corporation Hypotensive indolylalkylpiperidyl guanidines and isoureas
US4428954A (en) 1980-11-01 1984-01-31 John Wyeth And Brother Limited Method for treatment of cerebrovascular disorders
ZA822995B (en) * 1981-05-21 1983-12-28 Wyeth John & Brother Ltd Slow release pharmaceutical composition
FR2530632A1 (fr) * 1982-07-26 1984-01-27 Bouchara Emile Nouveaux derives substitues du 2,5-diamino 1,4-diazole, leurs procedes de preparation et les compositions pharmaceutiques en renfermant
DE3301758A1 (de) * 1983-01-20 1984-07-26 Merck Patent Gmbh, 6100 Darmstadt Indolderivate
JPS6084281A (ja) * 1983-09-14 1985-05-13 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド類
JPS60123485A (ja) * 1983-12-08 1985-07-02 Yoshitomi Pharmaceut Ind Ltd インド−ル−３−カルボキサミド誘導体
JPS60142981A (ja) * 1983-12-28 1985-07-29 Yoshitomi Pharmaceut Ind Ltd ３−インド−ルカルボキサミド誘導体
GB8406089D0 (en) * 1984-03-08 1984-04-11 Wyeth John & Brother Ltd Treatment/prevention of atherosclerotic disorders &c
US4569933A (en) * 1984-04-13 1986-02-11 Cornu Pierre Jean Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole
PH23498A (en) * 1984-08-06 1989-08-16 Sterling Drug Inc 3-carbonyl-1-aminoalkyl-1h-indoles,composition and use thereof
GB8422924D0 (en) * 1984-09-11 1984-10-17 Wyeth John & Brother Ltd Prevention of hypertension
EP0187619A3 (fr) * 1985-01-03 1987-08-26 Ciba-Geigy Ag Tétrahydropyridines 1,3-disubstituées
EP0187122A3 (fr) * 1985-01-03 1987-12-16 Ciba-Geigy Ag Azacycloalkanes, azacycloalcènes 1,3,4-trisubstitués
GB8531666D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
GB8531665D0 (en) * 1985-12-23 1986-02-05 Wyeth John & Brother Ltd Indole derivatives
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
US5004812A (en) * 1987-06-26 1991-04-02 E. I. Du Pont De Nemours And Company Direct positive dimethine cyanine dyes containing 1-aryl-2-heteroaryl indole nucleus
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
NZ241979A (en) * 1991-03-20 1996-01-26 Merck & Co Inc Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
CA2195850A1 (fr) * 1994-08-03 1996-02-15 Guillaume Lebaut Indoles substitues
WO1999055696A1 (fr) * 1998-04-28 1999-11-04 Arzneimittelwerk Dresden Gmbh Nouveaux hydroxyindoles, leur utilisation comme inhibiteurs de la phosphodiesterase 4 et leur procede de preparation
EP1118322A4 (fr) 1998-09-30 2004-10-20 Takeda Chemical Industries Ltd Medicaments qui ameliorent le pouvoir de vidange de la vessie
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
GB0130219D0 (en) * 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (fr) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Utilisations pharmaceutiques de ligands alpha2delta
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
OA13174A (en) 2003-05-30 2006-12-13 Ranbaxy Lab Ltd Substituted pyrrole derivatives and their use as HMG-Co inhibitors.
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US20050267096A1 (en) * 2004-05-26 2005-12-01 Pfizer Inc New indazole and indolone derivatives and their use pharmaceuticals
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
WO2006100588A1 (fr) * 2005-03-21 2006-09-28 Pfizer Limited Derives de triazole substitues utilises en tant qu'antagonistes d'oxytocine
DE602006003416D1 (de) * 2005-03-21 2008-12-11 Pfizer Ltd Substituierte triazolderivate als oxytocinantagonisten
WO2007017752A1 (fr) * 2005-08-10 2007-02-15 Pfizer Limited Derives de triazole substitues en tant qu'antagonistes d'oxytocine
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
CA2627599A1 (fr) 2005-11-08 2007-05-18 Ranbaxy Laboratories Limited Procede de preparation de sel hemicalcique d'acide (3r,5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxymethylphenylamino)carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoique
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2010127452A1 (fr) * 2009-05-04 2010-11-11 The Royal Institution For The Advancement Of Learning/Mcgill University Composés antagonistes des récepteurs 5-oxo-ete
CA2909442A1 (fr) 2013-04-17 2014-10-23 Pfizer Inc. Derives de n-piperidin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
EP3592736A1 (fr) * 2017-03-10 2020-01-15 Rutgers, the State University of New Jersey Dérivés d'indole utilisés en tant qu'inhibiteurs de pompe d'efflux
MA54261A (fr) 2019-01-18 2022-04-27 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2701797A (en) * 1955-02-08 - indolylmethyl
US2708197A (en) * 1952-05-24 1955-05-10 Upjohn Co Preparation of (hydroxy-3-indole)-alkylamines
US3014043A (en) * 1957-02-08 1961-12-19 Merck & Co Inc Serotonin antagonists
US3075986A (en) * 1958-01-09 1963-01-29 Rhone Poulenc Sa (1-piperdidylalkyl) derivatives of 3-indole
US3155668A (en) * 1960-04-11 1964-11-03 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl)-lower-alkyl]-tertiary amines and intermediates therefor
US3183235A (en) * 1961-06-27 1965-05-11 Sterling Drug Inc 1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
US3198807A (en) * 1961-07-25 1965-08-03 Substitutes carboxamide indoles and indolines
US3238215A (en) * 1963-10-17 1966-03-01 Sterling Drug Inc 1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3462440A (en) * 1965-12-03 1969-08-19 American Home Prod 1,4-bis(2-indol-3-ylethyl)piperidines

Also Published As

Publication number Publication date
CH528525A (de) 1972-09-30
DE1770460C3 (de) 1979-03-22
CH540916A (de) 1973-10-15
NL161359B (nl) 1979-09-17
IE32083L (en) 1968-11-24
DE1770460B2 (de) 1978-07-13
CH551428A (de) 1974-07-15
IN115974B (fr) 1975-08-16
GB1218570A (en) 1971-01-06
NL161359C (nl) 1980-02-15
DE1770460A1 (de) 1972-05-10
CH553796A (de) 1974-09-13
NL6807187A (fr) 1968-11-25
IE32083B1 (en) 1973-04-04
CH542221A (de) 1973-11-15
US3238215A (en) 1966-03-01
MY7100196A (en) 1971-12-31
FR7787M (fr) 1970-03-31
FR1582086A (fr) 1969-09-26
US3527761A (en) 1970-09-08

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: AMERICAN HOME PRODUCTS CORP.

Effective date: 19880522