BE688357A - Procede pour la preparation de derives de benzodiazepine - Google Patents
Procede pour la preparation de derives de benzodiazepineInfo
- Publication number
- BE688357A BE688357A BE688357DA BE688357A BE 688357 A BE688357 A BE 688357A BE 688357D A BE688357D A BE 688357DA BE 688357 A BE688357 A BE 688357A
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- benzodiazepine derivatives
- benzodiazepine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/28—Ethers with hydroxy compounds containing oxirane rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50238365A | 1965-10-22 | 1965-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE688357A true BE688357A (fr) | 1967-04-17 |
Family
ID=33300144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE688357D BE688357A (fr) | 1965-10-22 | 1966-10-17 | Procede pour la preparation de derives de benzodiazepine |
| BE688358D BE688358A (fr) | 1965-10-22 | 1966-10-17 | Procede pour la preparation de derives de benzodiazepine |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE688358D BE688358A (fr) | 1965-10-22 | 1966-10-17 | Procede pour la preparation de derives de benzodiazepine |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3481921A (da) |
| BE (2) | BE688357A (da) |
| BR (2) | BR6683863D0 (da) |
| CH (2) | CH497436A (da) |
| DE (2) | DE1695162A1 (da) |
| DK (2) | DK111489B (da) |
| ES (2) | ES332580A1 (da) |
| FR (4) | FR5905M (da) |
| GB (2) | GB1124157A (da) |
| IL (2) | IL26725A (da) |
| NL (2) | NL6614923A (da) |
| NO (2) | NO118326B (da) |
| SE (2) | SE334620B (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2024239B1 (da) * | 1968-11-26 | 1973-01-12 | Scherico Ltd | |
| US3932399A (en) * | 1973-07-27 | 1976-01-13 | Hoffmann-La Roche Inc. | 2,5-Epithio-1,4-benzodiazepines |
| US3925358A (en) * | 1973-07-27 | 1975-12-09 | Hoffmann La Roche | 1-Lower alkyl-2-substituted-1,4-benzodiazepines |
| US3873525A (en) * | 1973-08-29 | 1975-03-25 | Hoffmann La Roche | Preparation of 1-alkyl-1,4-benzodiazepin-2-ones |
| US4094870A (en) * | 1974-03-20 | 1978-06-13 | Fujisawa Pharmaceutical Co., Ltd. | 2-Substituted thio-1,4-benzodiazepine derivatives |
| US3869447A (en) * | 1974-05-13 | 1975-03-04 | Squibb & Sons Inc | 2,3,4,5-Tetrahydro-4-phenyl-1H-1,4-benzodiazepine-1-carboximidamide and related compounds |
| US4208327A (en) * | 1979-04-03 | 1980-06-17 | G. D. Searle & Co. | 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds |
| US4545935A (en) * | 1983-09-12 | 1985-10-08 | Iowa State University Research Foundation, Inc. | Amidoalkylation reactions of anilines |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2893922A (en) * | 1954-12-09 | 1959-07-07 | Union Carbide Corp | Continuous automatic coker |
| US3051701A (en) * | 1959-12-10 | 1962-12-28 | Benzodiazepine compounds |
-
1965
- 1965-10-22 US US502383A patent/US3481921A/en not_active Expired - Lifetime
-
1966
- 1966-10-11 CH CH1464766A patent/CH497436A/de not_active IP Right Cessation
- 1966-10-11 CH CH1464866A patent/CH473133A/de not_active IP Right Cessation
- 1966-10-13 DE DE19661695162 patent/DE1695162A1/de active Pending
- 1966-10-13 DE DE19661695161 patent/DE1695161A1/de active Pending
- 1966-10-17 BE BE688357D patent/BE688357A/xx unknown
- 1966-10-17 FR FR80185A patent/FR5905M/fr not_active Expired
- 1966-10-17 BE BE688358D patent/BE688358A/xx unknown
- 1966-10-18 FR FR80328A patent/FR1499512A/fr not_active Expired
- 1966-10-18 FR FR80330A patent/FR7192M/fr not_active Expired
- 1966-10-20 IL IL26725A patent/IL26725A/en unknown
- 1966-10-20 IL IL26724A patent/IL26724A/en unknown
- 1966-10-21 BR BR183863/66A patent/BR6683863D0/pt unknown
- 1966-10-21 NL NL6614923A patent/NL6614923A/xx unknown
- 1966-10-21 SE SE14437/66A patent/SE334620B/xx unknown
- 1966-10-21 ES ES0332580A patent/ES332580A1/es not_active Expired
- 1966-10-21 ES ES0332579A patent/ES332579A1/es not_active Expired
- 1966-10-21 DK DK547866AA patent/DK111489B/da unknown
- 1966-10-21 NL NL6614924A patent/NL6614924A/xx unknown
- 1966-10-21 NO NO165279A patent/NO118326B/no unknown
- 1966-10-21 BR BR183862/66A patent/BR6683862D0/pt unknown
- 1966-10-21 SE SE14438/66A patent/SE329856B/xx unknown
- 1966-10-21 DK DK547766AA patent/DK120548B/da unknown
- 1966-10-21 NO NO165280A patent/NO118918B/no unknown
- 1966-10-21 GB GB47302/66A patent/GB1124157A/en not_active Expired
- 1966-10-21 FR FR80920A patent/FR1502968A/fr not_active Expired
- 1966-10-21 GB GB47301/66A patent/GB1135336A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1135336A (en) | 1968-12-04 |
| US3481921A (en) | 1969-12-02 |
| CH473133A (de) | 1969-05-31 |
| IL26725A (en) | 1970-09-17 |
| NO118918B (da) | 1970-03-02 |
| CH497436A (de) | 1970-10-15 |
| DE1695161A1 (de) | 1970-12-10 |
| NL6614924A (da) | 1967-04-24 |
| BR6683862D0 (pt) | 1973-12-26 |
| DE1695162A1 (de) | 1970-12-10 |
| FR1502968A (fr) | 1967-11-24 |
| DK120548B (da) | 1971-06-14 |
| NO118326B (da) | 1969-12-15 |
| FR5905M (fr) | 1968-03-25 |
| IL26724A (en) | 1970-11-30 |
| SE329856B (da) | 1970-10-26 |
| SE334620B (da) | 1971-05-03 |
| ES332579A1 (es) | 1967-10-01 |
| NL6614923A (da) | 1967-04-24 |
| GB1124157A (en) | 1968-08-21 |
| ES332580A1 (es) | 1967-11-16 |
| FR7192M (da) | 1969-08-18 |
| BR6683863D0 (pt) | 1973-12-26 |
| FR1499512A (fr) | 1967-10-27 |
| DK111489B (da) | 1968-09-02 |
| BE688358A (fr) | 1967-04-17 |
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